Výsledky vyhledávání

Cryopreservation of allogeneic PBSC from related and unrelated donors is associated with delayed platelet engraftment but has no impact on survival

Autor: P Medd, Sandeep Nagra, Charles Craddock, D Hollyman, Ram Malladi

Publikováno v: Bone Marrow Transplantation. 48:243-248

Cryopreservation of PBSC for allo-SCT offers potential advantages; however, its impact on engraftment and outcomes remains unclear. A total of 76 allo-SCT performed using cryopreserved PBSC from HLA identical related (n=57) and unrelated donors (n=19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322bc05bad250b3c3a68c4a77aeb7475
https://doi.org/10.1038/bmt.2012.118

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An internal positive control for the enumeration of CD45+ and CD34+ cells by flow cytometry allows monitoring of reagent and operator performance

Autor: Martin G Guttridge, D. Hollyman, H. Belfield, A. Lankester, Suzanne M. Watt

Publikováno v: Cytotherapy. 9:275-282

Background Three-color flow cytometry assays are used to determine CD34 cell doses prior to stem cell transplantation. These assays require highquality reagents that are dispensed accurately to ensure reproducible results. We have developed a flow cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc70e7919c9289af8bf49374161ed98
https://doi.org/10.1080/14653240701247846

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REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial

Autor: A, King, D, Barton, H A, Beard, N, Than, J, Moore, C, Corbett, J, Thomas, K, Guo, I, Guha, D, Hollyman, D, Stocken, C, Yap, R, Fox, S J, Forbes, P N, Newsome

Publikováno v: BMJ Open

Introduction Liver disease mortality and morbidity are rapidly rising and liver transplantation is limited by organ availability. Small scale human studies have shown that stem cell therapy is safe and feasible and has suggested clinical benefit. No

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc43c2d53401731a80eaff8b1beafe08
https://pubmed.ncbi.nlm.nih.gov/25795699

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A Multicentre, Phase II, Open-Label, Randomised Controlled Trial of Repeated Autologous Infusions of Granulocyte Colony Stimulating Factor Mobilised Cd133 + Bone Marrow Stem Cells in Patients with Cirrhosis

Publikováno v: Journal of Hepatology. 64:S183-S184

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18d855e56af4e357ba0d173e7886845
https://doi.org/10.1016/s0168-8278(16)01695-0

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268. CD19-Targeted Normal and CLL Patient T Cells Expanded with Beads Can Eradicate Systemic Tumors In Vivo

Autor: D. Hollyman, Michel Sadelain, Isabelle Riviere, Renier J. Brentjens, Jolanta Stefanski, Mark Bonyhadi

Publikováno v: Molecular Therapy. 13

In order to conduct a clinical trial of adoptive therapy with genetically modified T cells in patients with CLL, we are investigating the feasibility of ex vivo T cell transduction and expansion using Xcyte|[trade]| Dynabeads|[reg]| to generate suffi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b483e443b2fe11a5bd2148f5e3b20499

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The application of lean manufacturing principles to a national network of cellular therapy laboratories

Autor: Martin G Guttridge, D. Hollyman, Anatole Lubenko, Claire Wiggins, J. Thompson, C. Ash, E. Austin, Jon Smythe, V. Day, S. Hurren

Publikováno v: Cytotherapy. 16:S44

helps to identify areas that accredited facilities need to improve and that FACT-JACIE needs to target for educational activities. Methods: Post inspection citations reviewed and approved by the FACT CT Accreditation Committee under the 3rd and 4th e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69a5cc6b360b906503556758b59f4647
https://doi.org/10.1016/j.jcyt.2014.01.152

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313. Cell Type Specific Media Optimization for Clinical Retroviral Transduction Protocols

Autor: Jolanta Stefanski, D. Hollyman, Ryan Kendle, Isabelle Riviere, Oriana Borquez-Ojeda, Michel Sadelain, Mark Przybylowski, Tulin Budak-Alpdogan

Publikováno v: Molecular Therapy. 13:S119-S120

In order to optimize the transduction of CD34+ cells, CD34+ derived Langerhans cells (LCs) and T lymphocytes for upcoming clinical trials, we determined which medium is best suited for each cell type. Our aim is to identify the formulation providing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e9f7a0d8218d1b7357e2b4abf449ec
https://doi.org/10.1016/j.ymthe.2006.08.369

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A phase I trial for the treatment of purine analog-refractory chronic lymphocytic leukemia using autologous T cells genetically targeted to the B cell specific antigen CD19

Autor: Mark L. Heaney, Shirley Bartido, Mark Przybylowski, D. Hollyman, Jolanta Stefanski, Michel Sadelain, Clare Taylor, Mark Weiss, Renier J. Brentjens, Oriana Borquez-Ojeda, Isabelle Riviere

Publikováno v: Journal of Clinical Oncology. 26:3045-3045

3045 Background: We have developed a novel immunotherapy strategy based on the genetic modification of patient T cells to recognize the B cell-specific cellular antigen CD19, expressed on B cell tu...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd5370fe5f38bcf761f8c2c8a7ec4357
https://doi.org/10.1200/jco.2008.26.15_suppl.3045

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