Zobrazeno 1 - 10
of 3 176
pro vyhledávání: '"D. Holliday"'
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100170- (2024)
The importance of a drug's kinetic profile and interplay of structure-kinetic activity with PK/PD has long been appreciated in drug discovery. However, technical challenges have often limited detailed kinetic characterization of compounds to the latt
Externí odkaz:
https://doaj.org/article/215d1b9e0e644570ab9c99b650955a7a
Autor:
Emanuela Talamonti, Jelena Davegardh, Anastasia Kalinovich, Sten M.M. van Beek, Nodi Dehvari, Carina Halleskog, Hamza M. Bokhari, Dana S. Hutchinson, Seungmin Ham, Laura J. Humphrys, Nicola C. Dijon, Aikaterini Motso, Anna Sandstrom, Evelyn Zacharewicz, Ilga Mutule, Edgars Suna, Jana Spura, Karolina Ditrychova, Leigh A. Stoddart, Nicholas D. Holliday, Shane C. Wright, Volker M. Lauschke, Soren Nielsen, Camilla Scheele, Elizabeth Cheesman, Joris Hoeks, Peter Molenaar, Roger J. Summers, Benjamin Pelcman, Gopala K. Yakala, Tore Bengtsson
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101931- (2024)
Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these recept
Externí odkaz:
https://doaj.org/article/3d4a3a5490234ea7a397025d54414624
Autor:
Granick, David
Publikováno v:
Journal of Economic Literature, 1980 Dec 01. 18(4), 1604-1607.
Externí odkaz:
https://www.jstor.org/stable/2724096
Autor:
Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Sebastian Furness, Nicholas D. Holliday, Bronwyn A. Evans, Roger J. Summers, Dana S. Hutchinson
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored
Externí odkaz:
https://doaj.org/article/8b05f72e8cfe40dba5549ad1377f554f
Autor:
Maren M. Hawkins, Daniel D. Holliday, Lance S. Weinhardt, Paul Florsheim, Emmanuel Ngui, Tala AbuZahra
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background There are over seven million older adult immigrants in the United States, and that number is expected to increase. Older adult immigrants in the United States have unique factors that influence their health. Methods In this integr
Externí odkaz:
https://doaj.org/article/8a8a32a9f8024f749ab70d5b15bfe06f
Autor:
Reggie Bosma, Nicola C. Dijon, Yang Zheng, Hannes Schihada, Niels J. Hauwert, Shuang Shi, Marta Arimont, Rick Riemens, Hans Custers, Andrea van de Stolpe, Henry F. Vischer, Maikel Wijtmans, Nicholas D. Holliday, Diederik W.D. Kuster, Rob Leurs
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104882- (2022)
Summary: In this study, we synthesized and evaluated new photoswitchable ligands for the beta-adrenergic receptors β1-AR and β2-AR, applying an azologization strategy to the first-generation beta-blocker propranolol. The resulting compounds (Opto-p
Externí odkaz:
https://doaj.org/article/febb6a52402644b994ea390ddeafdfc7
Autor:
Pryor, Frederic L.
Publikováno v:
Canadian Slavonic Papers / Revue Canadienne des Slavistes, 1980 Sep 01. 22(3), 425-426.
Externí odkaz:
https://www.jstor.org/stable/40867771
Publikováno v:
Research Management, 1985 Jan 01. 28(1), 42-42.
Externí odkaz:
https://www.jstor.org/stable/24120662
Autor:
Matthew Gibbs, Marcel Winnig, Irene Riva, Nicola Dunlop, Daniel Waller, Boris Klebansky, Darren W Logan, Stephen J Briddon, Nicholas D Holliday, Scott J McGrane
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277607 (2022)
As the most favoured animal companion of humans, dogs occupy a unique place in society. Understanding the senses of the dog can bring benefits to both the dogs themselves and their owners. In the case of bitter taste, research may provide useful info
Externí odkaz:
https://doaj.org/article/c4168cb992604476a8d28af15dfe6e90
Autor:
McIntyre, John R.
Publikováno v:
Technology and Culture, 1983 Jul 01. 24(3), 546-547.
Externí odkaz:
https://www.jstor.org/stable/3104799