Zobrazeno 1 - 10
of 687
pro vyhledávání: '"D. Hirst"'
Autor:
Véronique Sauvé, Eric Stefan, Nathalie Croteau, Thomas Goiran, Rayan Fakih, Nupur Bansal, Adelajda Hadzipasic, Jing Fang, Paramasivam Murugan, Shimin Chen, Edward A. Fon, Warren D. Hirst, Laura F. Silvian, Jean-François Trempe, Kalle Gehring
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Mutations in parkin and PINK1 cause early-onset Parkinson’s disease (EOPD). The ubiquitin ligase parkin is recruited to damaged mitochondria and activated by PINK1, a kinase that phosphorylates ubiquitin and the ubiquitin-like domain of pa
Externí odkaz:
https://doaj.org/article/df3c73716eab4203816680f5d6146ade
Autor:
Ali, Douaki, Annina, Stuber, Julien, Hengsteler, Dmitry, Momotenko, M., Rogers David, Walter, Rocchia, D., Hirst Jonathan, Nako, Nakatsuka, Denis, Garoli
Aptamer-based sensing of small molecules such as dopamine and serotonin in the brain, requires characterization of the specific aptamer sequences in solutions mimicking the in vivo environment with physiological ionic concentrations. In particular, d
Externí odkaz:
http://arxiv.org/abs/2308.13396
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106568- (2024)
Substantial work has been devoted to better understand the contribution of the myriad of genes that may underly the development of Parkinson's disease (PD) and their role in disease etiology. The small GTPase Ras-like without CAAX2 (RIT2) is one such
Externí odkaz:
https://doaj.org/article/3adcfb657fbd42559f2904e87d26312a
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-7 (2024)
Abstract Selecting greener solvents during experiment design is imperative for greener chemistry. While many solvent selection guides are currently used in the pharmaceutical industry, these are often paper-based guides which can make it difficult to
Externí odkaz:
https://doaj.org/article/00b074214d134abc8404a65f386ac9da
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Breakthroughs in efficient use of biogas fuel depend on successful separation of carbon dioxide/methane streams and identification of appropriate separation materials. In this work, machine learning models are trained to predict biogas separ
Externí odkaz:
https://doaj.org/article/b7fa63817c9544c0a9faaf445b9cd3a7
Autor:
S. J. Langan, D. Hirst
Publikováno v:
Hydrology and Earth System Sciences, Vol 8, Iss 3, Pp 422-435 (2004)
A long term record of water chemistry, consisting of twenty years of weekly spot samples, from three sub-catchments draining into a loch and the loch outflow in Galloway, S.W. Scotland have been analysed. The analysis undertaken consisted of a three
Externí odkaz:
https://doaj.org/article/6e439600a6d74fdd95b9be6c51881bfe
Autor:
Rachelle Driscoll, Lucas Hampton, Neeta A. Abraham, J. Douglas Larigan, Nadine F. Joseph, Juan C. Hernandez-Vega, Sarah Geisler, Fu-Chia Yang, Matthew Deninger, David T. Tran, Natasha Khatri, Bruno M. D. C. Godinho, Garth A. Kinberger, Daniel R. Montagna, Warren D. Hirst, Catherine L. Guardado, Kelly E. Glajch, H. Moore Arnold, Corrie L. Gallant-Behm, Andreas Weihofen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Huntington's disease (HD) is a progressive neurodegenerative disorder caused by CAG trinucleotide repeat expansions in exon 1 of the HTT gene. In addition to germline CAG expansions, somatic repeat expansions in neurons also contribute to HD
Externí odkaz:
https://doaj.org/article/708fdef928c448a8ad36da3b5a637de6
Autor:
Amber D. Van Laar, Katherine R. Webb, Matthew T. Keeney, Victor S. Van Laar, Alevtina Zharikov, Edward A. Burton, Teresa G. Hastings, Kelly E. Glajch, Warren D. Hirst, J. Timothy Greenamyre, Emily M. Rocha
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving
Externí odkaz:
https://doaj.org/article/3bb4b73d2d3c4865a71165a73daefadb
Autor:
Jean-Marc Taymans, Matt Fell, Tim Greenamyre, Warren D. Hirst, Adamantios Mamais, Shalini Padmanabhan, Inga Peter, Hardy Rideout, Avner Thaler
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Almost 2 decades after linking LRRK2 to Parkinson’s disease, a vibrant research field has developed around the study of this gene and its protein product. Recent studies have begun to elucidate molecular structures of LRRK2 and its complex
Externí odkaz:
https://doaj.org/article/ca18d0b49bf042a49e27c3300dadea0f
Autor:
Jonathan D. Hirst, Samuel Boobier, Jennifer Coughlan, Jessica Streets, Philippa L. Jacob, Oska Pugh, Ender Özcan, Simon Woodward
Publikováno v:
Artificial Intelligence Chemistry, Vol 1, Iss 2, Pp 100006- (2023)
The benefits of using machine learning approaches in the design, optimisation and understanding of homogeneous catalytic processes are being increasingly realised. We focus on the understanding and implementation of key concepts, which serve as condu
Externí odkaz:
https://doaj.org/article/daa27254025a4fd0810c53e3525143cc