Zobrazeno 1 - 10
of 50
pro vyhledávání: '"D. Hatley"'
Publikováno v:
Nature Reviews. Drug Discovery
Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel
Autor:
Richard J. D. Hatley, Steve P. McLachlan, Kathleen Baster, Lucy C. Gelder, Simon J. F. Macdonald
Publikováno v:
Journal of medicinal chemistry. 65(1)
A bibliometric study of authors across medicinal chemistry journals over 20 years reveals important trends. Most United States (US) based authors are assigned as racially/ethnically Asian or White; few are Black or Hispanic. More US coauthors have th
Autor:
Panayiotis A. Procopiou, Simon J. F. Macdonald, Ben S. Barksby, Jeni Luckett, Richard P. Marshall, Yim Man, Valerie S. Morrison, Lee A. Borthwick, Alex L Wilkinson, R. Gisli Jenkins, Elaine Gower, Rory Barnes, Alison E. John, Richard J. D. Hatley, John Barrett, K. Tao Pun, James A. Roper, Tim N. Barrett, Andrew J. Fisher, Robert J. Slack, Rachel A. Burgoyne
Publikováno v:
European journal of pharmacology. 913
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality. Activation of the pro-fibrotic cytokine transforming growth factor-β (TGFβ) via the alpha-V beta-6 (αvβ6) integrin
Autor:
Laura E. Westendorf, Steven P. McLachlan, William R. Ewing, Simon J. F. Macdonald, Richard J. D. Hatley, Nicholas A. Meanwell, Panayiotis A. Procopiou
Publikováno v:
Journal of medicinal chemistry. 63(23)
Writing scientific articles is immensely rewarding but challenging. This Perspective provides the medicinal chemist with background and advice on the art and process of writing manuscripts and complements the instructions to authors provided by journ
Publikováno v:
Anti-fibrotic Drug Discovery ISBN: 9781788015103
Fibrosis is the formation of abnormal scar tissue following repeated tissue injury, leading to the disruption of extracellular matrix homeostasis with loss of tissue architecture and function. In the developed world, fibrosis is a leading cause of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b162b7d79de70f58473b4e7ac19ebb16
https://doi.org/10.1039/9781788015783-00037
https://doi.org/10.1039/9781788015783-00037
Autor:
Joelle Le, Pauline T. Lukey, Steven B. Ludbrook, Simon J. F. Macdonald, Robert J. Slack, Richard J. D. Hatley
Publikováno v:
Angewandte Chemie. 130:3354-3379
Autor:
Sean P. Bew, Richard J. D. Hatley, Christopher J. Richards, Michael J. O’ Sullivan, Christopher Roland Wellaway
Publikováno v:
Tetrahedron. 100:132455
Reaction of methyl-2-(2-formylphenyl)acetate with primary amines in a reductive amination/cyclisation process resulted in N-substituted 1,4-dihydro-3(2H)-isoquinolinones. With H 2NCH 2R sodium borohyride is a suitable reductant (11 examples), but H 2
Autor:
K. Storer, Ben P. Marchant, Pete Berry, Alice E. Milne, D. R. Kindred, S. Clarke, S.L. Kendall, D. Hatley, Roger Sylvester-Bradley
Publikováno v:
Advances in Animal Biosciences. 8:303-307
A range of precision farming technologies are used commercially for variable rate applications of nitrogen (N) for cereals, yet these usually adjust N rates from a pre-set value, rather than predicting economically optimal N requirements on an absolu
Autor:
Douglas J. Minick, Royston C. B. Copley, Panayiotis A. Procopiou, Richard J. D. Hatley, Yanan He, Sean M. Lynn
Publikováno v:
Tetrahedron: Asymmetry. 27:1222-1230
Racemic N-CBZ-3-fluoropyrrolidine-3-methanol (±)-1 was resolved by preparative chiral HPLC. The absolute configuration of the enantiomers of 1 was identified by vibrational circular dichroism and confirmed by chemical synthesis, which involved excha
Publikováno v:
Drug discovery today. 25(3)
Pharmaceutical innovation is in short supply. Many diagnoses have been made and remedies prescribed by those in the industry and those that comment on it. There is much less practical advice for the individual about becoming more innovative or managi