Zobrazeno 1 - 10
of 1 038
pro vyhledávání: '"D. HOBBS"'
Autor:
Matthew Moll, Katherine A. Pratte, Catherine L. Debban, Congjian Liu, Steven A. Belinsky, Maria Picchi, Iain Konigsberg, Courtney Tern, Heena Rijhwani, Brian D. Hobbs, Edwin K. Silverman, Yohannes Tesfaigzi, Stephen S. Rich, Ani Manichaikul, Jerome I. Rotter, Russel P. Bowler, Michael H. Cho
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Protein biomarkers are associated with mortality in cardiovascular disease, but their effect on predicting respiratory and all-cause mortality is not clear. We tested whether a protein risk score (protRS) can improve prediction of all-cause
Externí odkaz:
https://doaj.org/article/a14437a45e4646ec8aaa2d10ea09498d
Autor:
Matthew Moll, Julian Hecker, John Platig, Jingzhou Zhang, Auyon J. Ghosh, Katherine A. Pratte, Rui-Sheng Wang, Davin Hill, Iain R. Konigsberg, Joe W. Chiles, III, Craig P. Hersh, Peter J. Castaldi, Kimberly Glass, Jennifer G. Dy, Don D. Sin, Ruth Tal-Singer, Majd Mouded, Stephen I. Rennard, Gary P. Anderson, Gregory L. Kinney, Russell P. Bowler, Jeffrey L. Curtis, Merry-Lynn McDonald, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105429- (2024)
Summary: Background: Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to define high-risk COPD subtypes using genetics (polygenic risk score
Externí odkaz:
https://doaj.org/article/a0549eb45ebc4c8e9d1d5f0c4da19d8b
Autor:
Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L. Curtis, Jennifer M. Wang, Rubén San José Estépar, Ivan O. Rosas, Jared R. Mayers, Brian D. Hobbs, Craig P. Hersh, Samuel Y. Ash, MeiLan K. Han, Russell P. Bowler, Kathleen A. Stringer, George R. Washko, Wassim W. Labaki
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Quantitative interstitial abnormalities (QIA) are an automated computed tomography (CT) finding of early parenchymal lung disease, associated with worse lung function, reduced exercise capacity, increased respiratory symptoms, and
Externí odkaz:
https://doaj.org/article/bce0f96bb4484586890684d92b6fd17c
Autor:
Andrew C. Hill, Claire Guo, Elizabeth M. Litkowski, Ani W. Manichaikul, Bing Yu, Iain R. Konigsberg, Betty A. Gorbet, Leslie A. Lange, Katherine A. Pratte, Katerina J. Kechris, Matthew DeCamp, Marilyn Coors, Victor E. Ortega, Stephen S. Rich, Jerome I. Rotter, Robert E. Gerzsten, Clary B. Clish, Jeffrey L. Curtis, Xiaowei Hu, Ma-en Obeidat, Melody Morris, Joseph Loureiro, Debby Ngo, Wanda K. O’Neal, Deborah A. Meyers, Eugene R. Bleecker, Brian D. Hobbs, Michael H. Cho, Farnoush Banaei-Kashani, Russell P. Bowler
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Privacy protection is a core principle of genomic but not proteomic research. We identified independent single nucleotide polymorphism (SNP) quantitative trait loci (pQTL) from COPDGene and Jackson Heart Study (JHS), calculated continuous pr
Externí odkaz:
https://doaj.org/article/9424c0bfdf7d4d96b4dca84e9697c383
Autor:
Brian D Hobbs, Jarrett D Morrow, Xu-Wen Wang, Yang-Yu Liu, Dawn L DeMeo, Craig P Hersh, Bartolome R Celli, Raphael Bueno, Gerard J Criner, Edwin K Silverman, Michael H Cho
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Chronic obstructive pulmonary disease (COPD) is a highly morbid and heterogenous disease. While COPD is defined by spirometry, many COPD characteristics are seen in cigarette smokers with normal spirometry. The extent to which COP
Externí odkaz:
https://doaj.org/article/71fcf811317242449509ba3e420604bc
Autor:
Lystra P. Hayden, Brian D. Hobbs, Robert Busch, Michael H. Cho, Ming Liu, Camila M. Lopes-Ramos, David A. Lomas, Per Bakke, Amund Gulsvik, Edwin K. Silverman, James D. Crapo, Terri H. Beaty, Nan M. Laird, Christoph Lange, Dawn L. DeMeo
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive
Externí odkaz:
https://doaj.org/article/71a1f12c51ed4f9e8a3f61b876cf0e2e
Autor:
Matthew Moll, Brian D. Hobbs, Aravind Menon, Auyon J. Ghosh, Rachel K. Putman, Takuya Hino, Akinori Hata, Edwin K. Silverman, John Quackenbush, Peter J. Castaldi, Craig P. Hersh, Michael J. McGeachie, Don D. Sin, Ruth Tal-Singer, Mizuki Nishino, Hiroto Hatabu, Gary M. Hunninghake, Michael H. Cho
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Interstitial lung abnormalities (ILA) are radiologic findings that may progress to idiopathic pulmonary fibrosis (IPF). Blood gene expression profiles can predict IPF mortality, but whether these same genes associate with ILA and
Externí odkaz:
https://doaj.org/article/51223a4fadff458db042a84805083d53
Autor:
Auyon J. Ghosh, Brian D. Hobbs, Jeong H. Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P. Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise, Fernando J. Martinez, Daniel McGoldrick, Michael H. Cho, Dawn L. DeMeo, Edwin K. Silverman, Peter J. Castaldi, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Craig P. Hersh
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These features have not been wel
Externí odkaz:
https://doaj.org/article/ded6f4fb9d3741b1812f3299d3b1e25c
Autor:
Yonghua Zhuang, Fuyong Xing, Debashis Ghosh, Brian D Hobbs, Craig P Hersh, Farnoush Banaei-Kashani, Russell P Bowler, Katerina Kechris
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284563 (2023)
Network approaches have successfully been used to help reveal complex mechanisms of diseases including Chronic Obstructive Pulmonary Disease (COPD). However despite recent advances, we remain limited in our ability to incorporate protein-protein inte
Externí odkaz:
https://doaj.org/article/985f27fda86d467f806647a29b4703f0
Autor:
Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal‐Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker‐Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry‐Lynn N. McDonald, COPDGene, ECLIPSE and SPIROMICS investigators
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1803-1817 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested t
Externí odkaz:
https://doaj.org/article/bf76ffb6e2b4400fa7635ccceb291578