Výsledky vyhledávání - "D. H. Wessels"

Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique

Autor: S. G. Pretorius, D. H. Wessels, R. H. A. Becker, H. E. Scholtz

Publikováno v: Diabetologia. 48:1988-1995

This single-dose, double-blind, randomised, parallel-group study evaluated the reproducibility in systemic exposure and glucodynamic effect of insulin glargine, NPH insulin (NPH) and insulin ultralente (ultralente) using the manually adjusted euglyca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e427c962029fa386b44af1e9ce237
https://doi.org/10.1007/s00125-005-1916-y

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Pharmacokinetics and Absolute Oral Bioavailability of an 800-mg Oral Dose of Telithromycin in Healthy Young and Elderly Volunteers

Autor: H.E. Scholtz, C. Perret, G. Montay, E. Sultan, D. H. Wessels, B. Lenfant, E. Weinling

Publikováno v: Chemotherapy. 48:217-223

Background: This two-way, randomized, single-dose, crossover study determined the pharmacokinetics and absolute oral bioavailability of telithromycin in young and elderly healthy subjects. Methods: Twelve young (18–40 years) and 12 elderly (>65 yea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67401b7da5ebcf1258c00c4f235cd81e
https://doi.org/10.1159/000066766

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Biotransformation of insulin glargine after subcutaneous injection in healthy subjects

Autor: S. G. Pretorius, C. Venter, E. Bernhardt, D. H. Wessels, T. Koose, M. A. Potgieter, U. Shukla, G. U. Kuerzel, A. M. Lang, H. E. Scholtz

Publikováno v: Current medical research and opinion. 19(1)

It is important to establish pharmacokinetic or pharmacodynamic differences between novel insulin analogues and human insulin. This study examined the primary metabolic degradation products of insulin glargine (LANTUS) in humans.In this single dose,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f02a86abf66094040c34a3341c6ccc2
https://pubmed.ncbi.nlm.nih.gov/12661778

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Equipotency of insulin glargine and regular human insulin on glucose disposal in healthy subjects following intravenous infusion

Autor: R. H. A. Becker, H. E. Scholtz, C. Venter, S. G. Pretorius, M. A. Potgieter, D. H. Wessels

Publikováno v: Acta diabetologica. 40(4)

The absolute glucose disposal of insulin glargine (Lantus) was compared to that of regular human insulin in healthy subjects (n=20) using the euglycaemic clamp technique in a single-dose, double-blind, randomized, two-way crossover design. Subjects r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab3ef615e46ed946f7ecda422d57f45
https://pubmed.ncbi.nlm.nih.gov/14740274

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A randomised, double blind, placebo controlled single ascending dose study of PYM50018, with an open label cross-over stage to assess food effect

Autor: R. Grover, L. Potgieter, D. H. Wessels, S. Levene, A. Frend

Publikováno v: Clinical Pharmacology & Therapeutics. 77:P67-P67

Background and Aims PYM50018 has neuroprotective properties and an emerging safety profile that make it a promising candidate for the treatment of neurodegenerative disorders, such as amyotrophic lateral sclerosis. This study evaluated the pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7932183d474fc904de37bab6ac1e3443
https://doi.org/10.1016/j.clpt.2004.12.146

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