Výsledky vyhledávání - "D. H. Showalter"

LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects

Autor: F. Tibaldi, Jenny Y. Chien, B. Ellis, H. D. H. Showalter, K. Schneck, P. Barrington

Publikováno v: Diabetes, Obesity and Metabolism. 13:434-438

Aim: To assess the safety, tolerability, pharmacokinetics, pharmacodynamics and potential immunogenicity of single, escalating subcutaneous injections of a once-weekly glucagon-like peptide-1 analogue in healthy subjects. Methods: This phase 1, three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a8f9b07a98e07cadeb822d8e3a4cd4
https://doi.org/10.1111/j.1463-1326.2011.01365.x

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A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes

Autor: Thomas Hardy, S. Cui, F. Tibaldi, B. Ellis, H. D. H. Showalter, P. Barrington, K. Schneck, Jenny Y. Chien

Publikováno v: Diabetes, Obesity and Metabolism. 13:426-433

Aim: To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of LY2189265 (LY), a novel, long-acting glucagen-like peptide-1 analogue, administered once weekly to subjects with type 2 diabetes. Methods: This was a placebo-contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736c7c0c9e6cba6e29026671f9427165
https://doi.org/10.1111/j.1463-1326.2011.01364.x

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Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor

Autor: Jeffrey Bruce Smaill, Brian D. Palmer, Alexander James Bridges, Bill J. Roberts, James M. Nelson, David W. Fry, Ellen M. Dobrusin, Gordon W. Rewcastle, R. T. Winters, W. L. Elliot, H. D. H. Showalter, S. J. Patmore, Patrick W. Vincent, William A. Denny, Zhou Hairong, W. R. Leopold, Dennis J. McNamara, V. Slintak

Publikováno v: Journal of medicinal chemistry. 42(10)

A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR) inhibitors were prepared from the corresponding amino compounds by reaction with either acryloyl ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97436fcf0b3737c2c47c6ea5c3bc1d50
https://pubmed.ncbi.nlm.nih.gov/10346932

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Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor

Autor: William A. Denny, Jeffrey Bruce Smaill, AM Doherty, James M. Hamby, Alan J. Kraker, Brian D. Palmer, TK Dahring, JB Kramer, DH Boschelli, Khatana Ss, Maruta Boyd, Robert L. Panek, R. T. Winters, Gina H. Lu, H. D. H. Showalter

Publikováno v: Journal of medicinal chemistry. 41(27)

1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure-activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b1b5f2bcf503f1d520e1f7178e91ca
https://pubmed.ncbi.nlm.nih.gov/9876115

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Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors

Autor: James M. Nelson, Gordon W. Rewcastle, D. K. Murray, Patrick W. Vincent, Curtis T. Howard, H. D. H. Showalter, William A. Denny, Bill J. Roberts, William L. Elliott, R. T. Winters, David W. Fry

Publikováno v: Journal of medicinal chemistry. 41(5)

The 4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidine PD 158780 is a very potent in vitro inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50 0.08 nM), and other members of the erbB family, by competitive bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b32f47d98b700584ad8a6f6e0f0890
https://pubmed.ncbi.nlm.nih.gov/9513602

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Drug residues in food animals II. Plasma and tissue kinetics of oxytetracycline in young cross-bred swine

Autor: Patricia E. Long, D. H. Showalter, Richard H. Teske, H. Dwight Mercer

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 1:119-128

Tissue distribution and elimination kinetics of oxytetracycline in sixteen organs and body fluids were determined in young pigs following intravenous and oral administration. Seventeen non-fasted pigs, 8–10 weeks of age, weight range 16.4–34.5 kg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf645789974158685aed40d7b7e976e0
https://doi.org/10.1111/j.1365-2885.1978.tb00315.x

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Drug residues in food animals. I. Plasma and tissue kinetics of chloramphenicol in young cross-bred swine

Autor: D. H. Showalter, George E. Heath, H. Dwight Mercer, Patricia E. Long, Thomas E. Powers

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 1:19-36

Eighteen non-fasted, 12–16 week old pigs weighing between 20 and 40 kg were dosed with chloramphenicol intravenously at a dose rate of 22 mg/kg body weight. The pharmacokinetics of chloramphenicol were determined in blood plasma and sixteen selecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f592588c52a6d690fa8e01d403d76cd5
https://doi.org/10.1111/j.1365-2885.1978.tb00301.x

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Comparative plasma kinetics of orally administered sulfamethazine in clinically parasitized and parasitism-treated lambs

Autor: D. H. Showalter, Richard H. Teske, H. F. Righter

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 2:203-208

Sulfamethazine was administered at a dosage of 99 mg/kg body weight to lambs with a naturally acquired parasitism and again at 37 days following treatment with an anthelmintic. Blood samples were analyzed for sulfonamides over a 72 h period following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57eba01404f675c98d3c2867aadd4cad
https://doi.org/10.1111/j.1365-2885.1979.tb00376.x

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Tissue residue depletion and recycling of sulfamethazine in swine

Autor: D M, Whipple, G, Samuelson, G E, Heath, D H, Showalter

Publikováno v: Journal of the American Veterinary Medical Association. 176(12)

Sulfamethazine was fed to weanling pigs at the rate of 100 g/ton of ration for 98 days to investigate the depletion rate of the drug from the plasma and edible tissues of swine. The mean plasma concentration of sulfamethazine for 21 treated pigs peak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb34b0c1e0a0eb659858e585c9bc306c
https://pubmed.ncbi.nlm.nih.gov/7429930

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