LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects

Autor: F. Tibaldi, Jenny Y. Chien, B. Ellis, H. D. H. Showalter, K. Schneck, P. Barrington

Publikováno v: Diabetes, Obesity and Metabolism. 13:434-438

Aim: To assess the safety, tolerability, pharmacokinetics, pharmacodynamics and potential immunogenicity of single, escalating subcutaneous injections of a once-weekly glucagon-like peptide-1 analogue in healthy subjects. Methods: This phase 1, three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a8f9b07a98e07cadeb822d8e3a4cd4
https://doi.org/10.1111/j.1463-1326.2011.01365.x

Synthesis of highly functional quinazolins via metal-free, visible-light-enabled radical cascade arylation/cyclization of fluorinated imidoyl isothiocyanates.

Autor: Yan Liang¹, Weigen Du¹, Xiaoqiong Zeng¹, Tiebo Xiao¹ xiaotb@kust.edu.cn, Yubo Jiang¹ ybjiang@kust.edu.cn

Publikováno v: Green Synthesis & Catalysis. Aug2024, Vol. 5 Issue 3, p200-204. 5p.

Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor

Autor: William A. Denny, Jeffrey Bruce Smaill, AM Doherty, James M. Hamby, Alan J. Kraker, Brian D. Palmer, TK Dahring, JB Kramer, DH Boschelli, Khatana Ss, Maruta Boyd, Robert L. Panek, R. T. Winters, Gina H. Lu, H. D. H. Showalter

Publikováno v: Journal of medicinal chemistry. 41(27)

1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure-activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b1b5f2bcf503f1d520e1f7178e91ca
https://pubmed.ncbi.nlm.nih.gov/9876115

Iridium-Catalyzed Reductive (3+2) Annulation of Lactams Enabling the Rapid Total Synthesis of (±)-Eburnamonine.

Autor: Sugiyama Y; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan., Yamada K; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan., Kaneko D; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan., Kusagawa Y; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan., Okamura T; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan., Sato T; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Feb 05; Vol. 63 (6), pp. e202317290. Date of Electronic Publication: 2023 Dec 28.

Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue.

Autor: Elgogary, Sameh R.^1,2 (AUTHOR) selgogary@gmail.com, El‑Telbani, Emad M.¹ (AUTHOR), Khidre, Rizk E.³ (AUTHOR)

Publikováno v: Polycyclic Aromatic Compounds. 2023, Vol. 43 Issue 9, p7769-7782. 14p.