CYP1A1 specificity of Verlukast epoxidation in mice, rats, rhesus monkeys, and humans

Autor: S J, Grossman, E G, Herold, J M, Drey, D W, Alberts, D R, Umbenhauer, D H, Patrick, D, Nicoll-Griffith, N, Chauret, J A, Yergey

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(6)

It has previously been shown that Verlukast is converted to Verlukast dihydrodiol in microsomes from beta-naphthoflavone (BNF)-treated, but not uninduced Swiss Webster mice and Sprague-Dawley rats. We have examined the involvement of CYP1A1 in this r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::721c8ecd07785ec50095f0db3cec2e28
https://pubmed.ncbi.nlm.nih.gov/7905381

Abstracts of scientific presentations

Autor: T. Miller, J. Skucas, D. Gudex, C. Listinsky, J. R. Hooyman, R. L. MacCarty, H. A. Carpenter, K. W. Schroeder, H. C. Carlson, H. I. Goldberg, X. Y. Ni, S. N. Glick, S. K. Teplick, P. Feczko, R. D. Halpert, R. A. Frost, D. Lamping, S. Somers, G. Stevenson, D. J. Ott, Y. M. Chen, D. W. Gelfand, W. C. Wu, H. A. Munitz, M. L. Janower, F. J. Schwab, C. C. Lu, J. Murakami, T. Barloon, S. R. Ell, E. A. Franken, J. Farman, E. Balthazar, B. R. Javors, B. Bashist, M. S. Levine, J. Langer, M. Kligerman, I. Laufer, R. L. Bree, R. E. Schwab, S. E. Rubesin, B. Jones, E. L. Wolf, D. Frager, J. Frager, L. J. Brandt, L. H. Bernstein, T. C. Beneventano, F. P. Agha, A. J. Megibow, D. H. Hulnick, E. J. Balthazar, P. M. Silverman, M. E. Baker, C. Cooper, F. M. Kelvin, S. Teefey, D. Stephens, E. James, W. Charboneau, P. Sheedy, W. Dodds, T. Lawson, R. Darweesh, E. Stewart, D. D. Stark, J. Wittenberg, J. T. Ferrucci, D. M. Williams, K. J. Cho, A. M. Aisen, W. Martel, C. D. Johnson, W. M. Thompson, R. Herfkens, J. Utz, K. J. Wolf, B. Hamm, T. Roemer, R. Felix, H. -J. Weinmann, S. Saini, R. Kane, G. Onik, G. Steele, U. Khettry, B. Cady, W. McDermott, R. Jenkins, M. Clouse, J. Katz, J. Gilbert, B. Rubinsky, M. Ohto, N. Sugiura, M. Ebara, K. Kimura, P. J. Weyman, E. Sonnenberg, G. R. Wittich, G. Casola, A. F. Hofmann, S. A. Wilson, V. W. Wing, P. H. Haskin, J. Sammon, A. H. Dachman, J. B. Nichols, D. H. Patrick, J. E. Lichtenstein, L. G. Hanelin, M. E. Lee, P. J. Feczko, R. Halpert, D. Kastan, L. Ackerman, J. Clark, J. M. Messmer, J. J. Bradley, S. R. Cho, M. A. Turner, M. A. Mauro, T. M. Swantkowski, E. V. Staab, E. M. Bozymski, W. Shea, D. Hohn, B. Demas, R. Kerlan, T. H. Reiman, D. M. Balfe, M. J. Ormson, J. W. Charboneau, D. H. Stephens, R. K. Zeman, L. R. Clark, P. L. Choyke, M. H. Jaffe, E. G. Grant, H. Ziessman, S. B. Benjamin

Publikováno v: Gastrointestinal Radiology. 11:291-299

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e961bee6d040139033bd09c6059e956
https://doi.org/10.1007/bf02035094

Pathogenicity of retroviruses containing either the normal human c-Ha-ras1 gene or its mutated form derived from the bladder carcinoma EJ/T24 cell line

Autor: E H, Chang, P L, Morgan, E J, Lee, K F, Pirollo, E A, White, D H, Patrick, P N, Tsichlis

Publikováno v: Journal of experimental pathology. 2(3)

Cellular ras oncogenes transduced by retroviruses carry mutations in amino acids 12, 59 and 122. Similar mutations have been observed in ras oncogenes activated during induction of neoplasia in both humans and experimental animals. The unmutated norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c95aec4a6ee63ed7cbf835d1b5e0c3fc
https://pubmed.ncbi.nlm.nih.gov/3842394

Evaluation of the zetacrit and zeta sedimentation ratio in dogs

Autor: D G, Martin, J E, Hall, D H, Patrick

Publikováno v: American journal of veterinary research. 46(6)

The Wintrobe erythrocyte sedimentation rate (ESR) has been used in animals and persons as a screening test for inflammatory disease and as a monitor for disease progression in individuals. Now, the zetacrit (ZC) and zeta sedimentation ratio (ZSR) are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b19c442fbaa84177b4c3d7df818172
https://pubmed.ncbi.nlm.nih.gov/4026009

Acute and subacute demyelination induced by mouse hepatitis virus strain A59 in C3H mice

Autor: J L, Woyciechowska, B D, Trapp, D H, Patrick, I C, Shekarchi, P O, Leinikki, J L, Sever, K V, Holmes

Publikováno v: Journal of experimental pathology. 1(4)

Mouse hepatitis virus (MHV, strain A-59), a coronavirus, induced acute and subacute demyelinating disease in the central nervous system of weanling C3H mice that were reported to be genetically resistant to MHV. Subtle clinical signs developed in gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1592d836696507b9e40b0ebc43dcf1fe
https://pubmed.ncbi.nlm.nih.gov/6100984