Výsledky vyhledávání - "D. H. Horber"

Oral antitumour activity in murine L1210 leukaemia and pharmacological properties of liposome formulations ofN 4-alkyl derivatives of 1-?-d-arabinofuranosylcytosine

Autor: H. Schott, Bernhard Odermatt, Reto A. Schwendener, D. H. Horber

Publikováno v: Journal of Cancer Research and Clinical Oncology. 122:102-108

The oral cytostatic activity in L1210 mouse leukaemia of the two new N4-alkyl derivatives of 1-beta-D-arabinofuranosylcytosine (AraC), N4-hexadecyl- and N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NH-AraC, NO-AraC) was investigated. In contrast t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a455d762dcb0fb5a2cbe7ee4e2443d5f
https://doi.org/10.1007/bf01226267

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Cytotoxicity, cell-cycle perturbations and apoptosis in human tumor cells by lipophilic N4-alkyl-1-beta-D-arabinofuranosylcytosine derivatives and the new heteronucleoside phosphate dimer arabinocytidylyl-(5'--5')-N4-octadecyl-1-beta-D-arabinofuranosylcytosi ne

Autor: P. von Ballmoos, H. Schott, D. H. Horber, S. Eriksson, Peter Stephan Ludwig, Rosanna M. C. Cattaneo-Pangrazzi, Reto A. Schwendener, Iduna Fichtner

Publikováno v: Journal of cancer research and clinical oncology. 126(6)

The arabinofuranosylcytosine (AraC) derivative N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) and its (5'-->5')-heterodinucleoside phosphate analog NOAC-AraC were compared with AraC for cytotoxicity, cell-cycle dependence, phosphorylation by d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8b9600a4486699a9c787c75a052bcb
https://pubmed.ncbi.nlm.nih.gov/10870640

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Pharmacokinetic properties and interactions with blood components of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC) incorporated into liposomes

Autor: H. Schott, D. H. Horber, C. Ottiger, Reto A. Schwendener

Publikováno v: The Journal of pharmacy and pharmacology. 47(4)

N 4-Hexadecyl-1-β-d-arabinofuranosylcytosine (NHAC) is a new lipophilic derivative of 1-β-d-arabino-furanosylcytosine (ara-C) with strong antitumour activity. The interactions of NHAC incorporated into small unilamellar liposomes of different compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1e19d2e0a66fa533f68d6dd4ab016b
https://pubmed.ncbi.nlm.nih.gov/7791024

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Cell cycle-dependent cytotoxicity and induction of apoptosis by liposomal N4-hexadecyl-1-beta-D-arabinofuranosylcytosine

Autor: D. H. Horber, H. Schott, P. von Ballmoos, Reto A. Schwendener

Publikováno v: British Journal of Cancer

The clonogenic growth inhibition, the cell cycle dependence of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC) cytotoxicity and the capability to induce apoptosis in ara-C-sensitive and -resistant HL-60 cells were investigated and compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc87a8f91c033ed0a8bd4b9a69517224

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Cell cycle dependent cytotoxicity and induction of apoptosis by N4-hexadecyl-cytosine arabinoside (NHAC), a new lipophilic derivative of cytosine arabinoside

Autor: H. Schott, D. H. Horber, Reto A. Schwendener, P. von Ballmoos

Publikováno v: Journal of Cancer Research and Clinical Oncology. 121:A2-A2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff2a5213526bad58fc6f650b5a913fe2
https://doi.org/10.1007/bf02571970

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