Zobrazeno 1 - 10
of 110
pro vyhledávání: '"D. H. Caignard"'
Autor:
Ignacio Aldana, Isabel Rivero, Argimiro Rivero, Patricio Huenchuñir, Carmen Frigola, Maria Luisa Alonso, Antonio Monge, D. H. Caignard, P. Renard
Publikováno v:
Química Nova, Vol 23, Iss 6, Pp 737-741 (2000)
In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and prelimina
Externí odkaz:
https://doaj.org/article/31d36c748b8f448fbcafc3ce2401aeb5
Autor:
Ignacio Aldana, Silvia Galiano, D. H. Caignard, Saioa Ancizu, Philippe Delagrange, Antonio Monge, Silvia Pérez-Silanes, Nerea Castrillo
Publikováno v:
Molecules
Volume 17
Issue 7
Pages 7737-7757
Volume 17
Issue 7
Pages 7737-7757
Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49a39d890716d943431284fbb350c06
https://doi.org/10.3390/molecules17077737
https://doi.org/10.3390/molecules17077737
Autor:
Carmen Maiereanu, Alain Pierré, Nathalie Ayerbe, Gérard Coudert, Stéphane Léonce, Sylvain Routier, Isabelle Gillaizeau, D. H. Caignard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4670-4674
We report the efficient synthesis and biological evaluation of new benzodioxinoindolocarbazoles heterocycles (BDCZs) designed as potential anticancer agents. Indolic substitution and maleimide variations were performed to design a new library of BDCZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3ab0e9d901e94c14b1e1167bb3c63d
https://doi.org/10.1016/j.bmcl.2010.05.088
https://doi.org/10.1016/j.bmcl.2010.05.088
Publikováno v:
Tetrahedron. 64:11020-11027
An efficient synthesis of new dioxygenated isoquinolines is reported. The novelty of this approach derives from its use of tricyclic-nitril ( 3 ) as a building block in a synthetic sequence of seven steps for the preparation of the tetracyclic isoqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590522cd3ad4ff5b8832dd96dab1f5a7
https://doi.org/10.1016/j.tet.2008.09.097
https://doi.org/10.1016/j.tet.2008.09.097
Publikováno v:
Medicinal Chemistry Research. 14:158-168
In an effort to produce a new pharmacological probe with high affinity and selectivity for the sigma-1 receptor, we have synthesized a series of original 2(3H)-benzothiazolones utilizing compound 4 [3-(1-piperidinoethyl)-6-propylbenzothiazolin-2-one]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e20ce4444070324a2529fb18677b0c
https://doi.org/10.1007/s00044-005-0131-1
https://doi.org/10.1007/s00044-005-0131-1
Autor:
Nathalie Dias, D. H. Caignard, Alain Pierré, Gérard Coudert, Sylvain Routier, Jean-Yves Mérour, Christian Bailly, Paul Peixoto, Stéphane Léonce
Publikováno v:
Journal of Medicinal Chemistry. 48:1401-1413
We report the efficient synthesis involving palladium-catalyzed reactions and biological evaluation of new naphthocarbazoles designed as potential anticancer agents. The use of 5- and 6-benzyloxyindoles generated three substitution sites which were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596bffdb915196804e435ab333f6c7b5
https://doi.org/10.1021/jm049213f
https://doi.org/10.1021/jm049213f
Publikováno v:
Tetrahedron. 57:8297-8303
The isoquinoline 17 and the tetrahydroisoquinoline 16 were synthesized from 2,3-dihydro-1,4-benzodioxin (1) by different synthetic strategies. Preparation of arylethylamines and their cyclization in Bischler–Napieralski conditions have been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330c8ab9e7563664f0d117760e928c58
https://doi.org/10.1016/s0040-4020(01)00826-2
https://doi.org/10.1016/s0040-4020(01)00826-2
Autor:
Pascal Carato, O. Diouf, Daniel Lesieur, C. Belzung, M. C. Rettori, D. H. Caignard, Jean-Paul Bonte, B. Guardiola‐Lemaitre, Patrick Depreux
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2579-2584
A series of new benzothiazolin-2-one, benzoxazolin-2-one and benzoxazin-3-one derivatives were synthesized and their binding profile at 5-HT1A, 5-HT2A, 5-HT2C as well as D2 and α1 receptors was determined. All studied compounds displayed high to mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06380df3d47aa7626d2f2c94c9c35f6f
https://doi.org/10.1016/s0960-894x(97)10023-3
https://doi.org/10.1016/s0960-894x(97)10023-3
Autor:
Daniel Lesieur, Peter J. Morgan, Pierre Renard, Philippe Delagrange, Patrick Depreux, B. Guardiola-Lemaitre, V. Leclerc, D. H. Caignard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1071-1076
A serie of rotationally restricted tricyclic naphthalenic and tetrahydronaphthalenic analogs of the hormone melatonin has been synthesized, the C-7 oxygen being incorporated in a pyran, furan or dioxan heterocyclic ring. The receptor binding profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282ee4ef7d14957c6340c293dba41ba4
https://doi.org/10.1016/0960-894x(96)00175-8
https://doi.org/10.1016/0960-894x(96)00175-8
Autor:
M. P. Vaccher, D. H. Caignard, François Durant, M. Ansar, R. Mouhoub, Guy Evrard, N. Flouquet, Michel Debaert, Claude Vaccher, Pierre Renard, S Al Akoum Ebriki, M. C. Rettori, Bernard Pirard, Pascal Berthelot
Publikováno v:
European Journal of Medicinal Chemistry. 31:449-460
Summary Baclofen (β- p -chlorophenyl GABA) is one of the selective agonists for the bicuculline-insensitive GABA B receptors. In the search for new compounds that bind to GABA B receptors it is very important to clarify the structural requirements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6ad25e52ca99f6b4586a707bd92717
https://doi.org/10.1016/0223-5234(96)85165-8
https://doi.org/10.1016/0223-5234(96)85165-8