Zobrazeno 1 - 10
of 574
pro vyhledávání: '"D. Gwyn"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionThe treatment landscape of small cell lung cancer (SCLC) is evolving. Evidence generated from administrative claims is needed to characterize real-world SCLC patients. However, the current ICD-10 coding system cannot distinguish SCLC from
Externí odkaz:
https://doaj.org/article/0ee4a5300bcf4613b5d48073afe4ded0
Publikováno v:
Pulmonary Therapy, Vol 9, Iss 3, Pp 435-450 (2023)
Abstract Introduction Understanding of the patient-perceived symptom burden of small cell lung cancer (SCLC) is limited. The objective of this study was to explore patients’ experiences with SCLC, identify which treatment-/disease-related symptoms
Externí odkaz:
https://doaj.org/article/8317d390659f4377b1ef8a86db66a285
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The fate of mesoscale eddy kinetic energy represents a large source of uncertainty in the global ocean energy budget. Satellite altimetry suggests that mesoscale eddies vanish at ocean western boundaries. However, the fate of the eddies’ k
Externí odkaz:
https://doaj.org/article/fd248843b42c4ab7b042e9186c9b282a
Autor:
Heidi A. I. Grosjean, Samantha Dolter, Daniel E. Meyers, Philip Q. Ding, Igor Stukalin, Siddhartha Goutam, Shiying Kong, Quincy Chu, Daniel Y. C. Heng, D. Gwyn Bebb, Don G. Morris, Winson Y. Cheung, Aliyah Pabani
Publikováno v:
Current Oncology, Vol 28, Iss 5, Pp 4213-4222 (2021)
The emergence of immunotherapy revolutionized the treatment of non-small-cell-lung cancer (NSCLC), with multiple landmark clinical trials establishing the efficacy of these agents. However, many patients who receive immunotherapy in clinical practice
Externí odkaz:
https://doaj.org/article/ef1a3db40d2d4a92a300be45448be0e8
Autor:
Dylan E. O’Sullivan, Winson Y. Cheung, Iqra A. Syed, Daniel Moldaver, Mary Kate Shanahan, D. Gwyn Bebb, Christina Sit, Darren R. Brenner, Devon J. Boyne
Publikováno v:
Current Oncology, Vol 28, Iss 4, Pp 3091-3103 (2021)
The prognosis for extensive-stage small cell lung cancer (ES-SCLC) is poor. Real-world evidence can highlight the unmet clinical need within this population. We conducted a population-based cohort study of ES-SCLC patients diagnosed in a large Canadi
Externí odkaz:
https://doaj.org/article/6f3061a84340489da0e3d7b1de11619b
Autor:
D. Gwyn Bebb, Shantanu Banerji, Normand Blais, Patrice Desmeules, Sharlene Gill, Andrea Grin, Harriet Feilotter, Aaron R. Hansen, Martin Hyrcza, Monika Krzyzanowska, Barbara Melosky, Jonathan Noujaim, Bibiana Purgina, Dean Ruether, Christine E. Simmons, Denis Soulieres, Emina Emilia Torlakovic, Ming-Sound Tsao
Publikováno v:
Current Oncology, Vol 28, Iss 1, Pp 523-548 (2021)
The tyrosine receptor kinase (TRK) inhibitors larotrectinib and entrectinib were recently approved in Canada for the treatment of solid tumours harbouring neurotrophic tyrosine receptor kinase (NTRK) gene fusions. These NTRK gene fusions are oncogeni
Externí odkaz:
https://doaj.org/article/26b6b4635f4c4bc38700f58082fed210
Autor:
Maarten S. Heijnen, Michael A. Clare, Matthieu J. B. Cartigny, Peter J. Talling, Sophie Hage, D. Gwyn Lintern, Cooper Stacey, Daniel R. Parsons, Stephen M. Simmons, Ye Chen, Esther J. Sumner, Justin K. Dix, John E. Hughes Clarke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The authors analyse 9 years of time-lapse surveys in Bute Inlet, British Columbia (CA), to show how an active submarine channel evolves. They show how channel evolution is controlled by fast upstream-migration of steep knickpoints, which are similar
Externí odkaz:
https://doaj.org/article/ec7a423e3da249999882ceea1e6cfb11
Autor:
Anifat A. Elegbede, MSc, MbChB, Amanda J. Gibson, BSc, Andrea S. Fung, PhD, MD, Winson Y. Cheung, MD, MPH, Michelle L. Dean, BSc, D. Gwyn Bebb, BMBCh, PhD, Aliyah Pabani, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 12, Pp 100249- (2021)
Introduction: The real-world data evaluating treatment outcomes of atezolizumab plus carboplatin-etoposide chemotherapy (atezolizumab) for extensive-stage SCLC (ESCLC) are lacking. Our objective was to evaluate real-world outcomes of ESCLC treated wi
Externí odkaz:
https://doaj.org/article/6d9518960e1846f9a1d2a211e151b458
Publikováno v:
Water, Vol 15, Iss 1, p 167 (2022)
Changes in climate affect the hydrological regime of rivers worldwide and differ with geographic location and basin characteristics. Such changes within a basin are captured in the flux of water and sediment at river mouths, which can impact coastal
Externí odkaz:
https://doaj.org/article/194dd83bbf1042d493f2bfb39d5d9bdf
Autor:
Amanda J.W. Gibson, BSc (Hons), Adrian Box, MD, PhD, Michelle L. Dean, BSc, Anifat A. Elegbede, MSc, Desiree Hao, MD, Randeep Sangha, MD, D. Gwyn Bebb, BMBCh, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 4, Pp 100157- (2021)
Introduction: This study explored the use, safety, and efficacy of initial use of an ALK-inhibiting targeted therapy (ALK tyrosine kinase inhibitor [TKI]) in patients with ALK-rearranged NSCLC in a population-based, real-world clinical population wit
Externí odkaz:
https://doaj.org/article/7caa4c9d3fd2409c996385d60ce3c991