Zobrazeno 1 - 10
of 58
pro vyhledávání: '"D. Gunasinghe"'
Autor:
D. Ranasinghe, C. Jeewandara, T. Jayadas, D. Jayathilaka, D. Gunasinghe, F. Bary, R. Perera, H. Kuruppu, D. Ariyaratne, G. Ogg, G. Malavige
Publikováno v:
International Journal of Infectious Diseases, Vol 134, Iss , Pp S11-S12 (2023)
Intro: Sri Lanka detected the first infection due to BA.1 back in November 2021, which was quickly replaced by BA.2 by end of January. With detection of BA.5.2 in late June 2022, the number of symptomatic cases has increased without a similar increas
Externí odkaz:
https://doaj.org/article/d09959f20e214cbda7dd204ce98f0d73
Autor:
T.T. Pramanayagam Jayadas, C. Jeewandara, D. Jayathilaka, D. Ranasinghe, D. Ariyarathne, A. Wijesinghe, D. Gunasinghe, L. Gomes, D. Madushanka, O. Dissanayake, M. Harvie, F. Bary, N. Malavige
Publikováno v:
International Journal of Infectious Diseases, Vol 116, Iss , Pp S34- (2022)
Purpose: Surveillance of different SARS-CoV-2 variants of concern (VOCs) is a crucial aspect in control of the pandemic. Although sequencing is the gold-standard to detect VOCs, it is labor intensive and is costly. We compared a cost-effective real-t
Externí odkaz:
https://doaj.org/article/52109d8230fb413989c03e8f99c143b8
Autor:
Marcin Wegrecki, Tonatiuh A. Ocampo, Sachith D. Gunasinghe, Anouk von Borstel, Shin Yi Tin, Josephine F. Reijneveld, Thinh-Phat Cao, Benjamin S. Gully, Jérôme Le Nours, D. Branch Moody, Ildiko Van Rhijn, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
T cell receptors are generally thought to contact antigens presented in an end to end configuration. Here the authors show a geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a γδ T cell receptor.
Externí odkaz:
https://doaj.org/article/a5eb21242f424541a6a488c362e95bcb
Autor:
Sachith D. Gunasinghe, Takuya Shiota, Christopher J. Stubenrauch, Keith E. Schulze, Chaille T. Webb, Alex J. Fulcher, Rhys A. Dunstan, Iain D. Hay, Thomas Naderer, Donna R. Whelan, Toby D.M. Bell, Kirstin D. Elgass, Richard A. Strugnell, Trevor Lithgow
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2782-2794 (2018)
The β-barrel assembly machinery (BAM) complex is essential for localization of surface proteins on bacterial cells, but the mechanism by which it functions is unclear. We developed a direct stochastic optical reconstruction microscopy (dSTORM) metho
Externí odkaz:
https://doaj.org/article/4887ae9993cc45509e28c04949566915
Super-Resolution Imaging of Protein Secretion Systems and the Cell Surface of Gram-Negative Bacteria
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Gram-negative bacteria have a highly evolved cell wall with two membranes composed of complex arrays of integral and peripheral proteins, as well as phospholipids and glycolipids. In order to sense changes in, respond to, and exploit their environmen
Externí odkaz:
https://doaj.org/article/d43c2560c9fd47e1b7b1a6afc03e4506
Autor:
Daniel J. Nieves, Elvis Pandzic, Sachith D. Gunasinghe, Jesse Goyette, Dylan M. Owen, J. Justin Gooding, Katharina Gaus
Publikováno v:
Nanoscale. 14(9)
T cells are highly sensitive to low levels of antigen, but how this sensitivity is achieved is currently unknown. Here, we imaged proximal TCR-CD3 signal propagation with single molecule localization microscopy (SMLM) in T cells activated with nanosc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0a9d9818357a7657956445fc151fe5
https://pubmed.ncbi.nlm.nih.gov/35171177
https://pubmed.ncbi.nlm.nih.gov/35171177
Autor:
Subhash Dhital, Pankaj Deo, Manasa Bharathwaj, Kristy Horan, Joshua Nickson, Mohammad Azad, Isabella Stuart, Seong H Chow, Sachith D Gunasinghe, Rebecca Bamert, Jian Li, Trevor Lithgow, Benjamin P Howden, Thomas Naderer
Publikováno v:
microLife. 3
Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea. The treatment of gonorrhoea is becoming increasingly challenging, as N. gonorrhoeae has developed resistance to antimicrobial agents routinely used in the clinic. Resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03d5d2150d97ad3efb8a562b28e318be
https://doi.org/10.1093/femsml/uqac013
https://doi.org/10.1093/femsml/uqac013
Akademický článek
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Autor:
Trevor Lithgow, Rhys A. Dunstan, Jian Li, Sachith D. Gunasinghe, Pok Man Leung, Anton Y. Peleg, Ashleigh Kropp, Simone Beckham, Rhys Grinter, Matthew J Belousoff, Chris Greening, Eva Heinz, Faye C. Morris, Nichollas E. Scott
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
Acinetobacter baumannii is a high-risk pathogen due to the rapid global spread of multidrug-resistant lineages. Its phylogenetic divergence from other ESKAPE pathogens means that determinants of its antimicrobial resistance can be difficult to extrap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2bf25134fcdbe3390241c6d5ad3328
https://journals.asm.org/doi/10.1128/mBio.01480-21
https://journals.asm.org/doi/10.1128/mBio.01480-21
Autor:
Rhys, Grinter, Faye C, Morris, Rhys A, Dunstan, Pok Man, Leung, Ashleigh, Kropp, Matthew, Belousoff, Sachith D, Gunasinghe, Nichollas E, Scott, Simone, Beckham, Anton Y, Peleg, Chris, Greening, Jian, Li, Eva, Heinz, Trevor, Lithgow
Publikováno v:
mBio
Acinetobacter baumannii is a high-risk pathogen due to the rapid global spread of multidrug-resistant lineages. Its phylogenetic divergence from other ESKAPE pathogens means that determinants of its antimicrobial resistance can be difficult to extrap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f840abc50a2b3a4f0d3bce753fb33676
https://pubmed.ncbi.nlm.nih.gov/34311571
https://pubmed.ncbi.nlm.nih.gov/34311571