Zobrazeno 1 - 10
of 86
pro vyhledávání: '"D. Guarnaccia"'
Autor:
Sarah A. Streeter, Alexandria G. Williams, James R. Evans, Jing Wang, Alissa D. Guarnaccia, Andrea C. Florian, Rafet Al-Tobasei, Qi Liu, William P. Tansey, April M. Weissmiller
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impai
Externí odkaz:
https://doaj.org/article/073c9794a0504f28b71f32dd3bcd78ec
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 101000- (2021)
Summary: Genome-wide nuclear run-ons are a powerful way to determine the impact of a perturbation such as transcription factor degradation on transcriptional patterns. But often investigators are interested in monitoring transcriptional effects at sp
Externí odkaz:
https://doaj.org/article/f709b20919794452a8b4231d8a62fe6e
Autor:
Stephen W. Fesik, Dai H. Chung, William P. Tansey, David K. Flaherty, Alissa D. Guarnaccia, Eric J. Rellinger, April M. Weissmiller, Shelly L. Lorey, Brittany K. Matlock, Erin R. Aho, Chase M Woodley, Gregory C. Howard, Qi Liu, Audra F Bryan, Jing Wang
Publikováno v:
Nucleic Acids Research
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e98e8c1595ddbc0d9942a951da6351
https://doi.org/10.1093/nar/gkaa051
https://doi.org/10.1093/nar/gkaa051
Autor:
Philamer C. Calses, Victoria C. Pham, Alissa D. Guarnaccia, Meena Choi, Erik Verschueren, Sietske T. Bakker, Trang H. Pham, Trent Hinkle, Chad Liu, Matthew T. Chang, Noelyn Kljavin, Corey Bakalarski, Benjamin Haley, Jianing Zou, Cuicui Yan, Xia Song, Xiaoyan Lin, Rebecca Rowntree, Alan Ashworth, Anwesha Dey, Jennie R. Lill
Publikováno v:
Molecular & Cellular Proteomics. 22:100496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a6afa8107524a43cccd9e3311eacf8
https://doi.org/10.1016/j.mcpro.2023.100496
https://doi.org/10.1016/j.mcpro.2023.100496
Autor:
Alissa D. Guarnaccia, Christina E. Wang, April M. Weissmiller, Jing Wang, William P. Tansey, William G. Payne, Kristie L. Rose, Kiana Guerrazzi, J. Grace Shaw, Edward T. Olejniczak, Salisha Hill, Tessa M. Popay, Stephen W. Fesik, Chase M Woodley, Qi Liu, Tyler J. Hansen, Bin Zhao, Shelly L. Lorey
Publikováno v:
Cell reports
SUMMARY The chromatin-associated protein WDR5 is a promising pharmacological target in cancer, with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called the WIN site. Despite a clear expectation that WIN site inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58182266d573428ca6a794d5618db45
http://europepmc.org/articles/PMC7871196
http://europepmc.org/articles/PMC7871196
Publikováno v:
Journal of Clinical Medicine, Vol 7, Iss 2, p 21 (2018)
Journal of Clinical Medicine
Journal of Clinical Medicine
WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes, but emerging evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38ae5c2cc420ef04d7d9e8db3c96782
http://www.mdpi.com/2077-0383/7/2/21
http://www.mdpi.com/2077-0383/7/2/21
Autor:
D. Guarnaccia, Filippo Pinelli, Barbara Albertini, Paolo Blasi, Gian Carlo Di Renzo, Maurizio Ricci, Mirco Della Vecchia, Aurelie Marie Madeleine Schoubben
Publikováno v:
Journal of Agricultural and Food Chemistry. 63:9948-9953
Cocoa seed polyphenols have demonstrated interesting beneficial effects in humans. Most polyphenols contained in fresh seeds are chemically modified during fermentation, drying, and cocoa powder or chocolate production. The improvement of these proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f71e405690e07909545c3511caf9d0b
https://doi.org/10.1021/acs.jafc.5b01062
https://doi.org/10.1021/acs.jafc.5b01062
Publikováno v:
Cancer Research. 78:972-972
MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies and contributes to the deaths of ~100,000 Americans each year. The tumorigenic functions of MYC stem from its influence on the transcriptional program of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3740eebbe19f9695a2b6d0c0ac00016
https://doi.org/10.1158/1538-7445.am2018-972
https://doi.org/10.1158/1538-7445.am2018-972
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Publikováno v:
Cancer Research. 77:4994-4994
MYC is an oncoprotein that is overexpressed in the majority of malignancies and contributes to an estimated 70,000-100,000 cancer deaths in the United States every year. The broad pro-tumorigenic functions of MYC stem from its role as a sequence-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df17429ee64f29cd90c7c0ed20b627e9
https://doi.org/10.1158/1538-7445.am2017-4994
https://doi.org/10.1158/1538-7445.am2017-4994