Zobrazeno 1 - 10
of 27
pro vyhledávání: '"D. Greg Hall"'
Autor:
Leijun Hu, Jeanelle Kam, William H. Landschulz, Masako Nakano, Xiao Yan Yang, Arie Regev, Claire Smith, Jack Uetrecht, Terry A. McNearney, Y. Jin, D. Greg Hall, Kristina M. Campanale, Krista M Phipps, Judith W. Henck
Publikováno v:
British Journal of Clinical Pharmacology. 84:179-188
SummaryAim LY3031207, a novel microsomal prostaglandin E synthase 1 inhibitor, was evaluated in a multiple ascending dose study after nonclinical toxicology studies and a single ascending dose study demonstrated an acceptable toxicity, safety, and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23bfef4e831205a4b8c6206463f805aa
https://doi.org/10.1111/bcp.13423
https://doi.org/10.1111/bcp.13423
Publikováno v:
Toxicologic Pathology for Non-Pathologists ISBN: 9781493997763
The musculoskeletal system provides vital functions such as protection of fragile tissues, support, contribution to mineral homeostasis, and locomotion. In this chapter, we cover toxicologic pathology of importance to the nonpathologist in three majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1460c7c9106bee454547774736c9c652
https://doi.org/10.1007/978-1-4939-9777-0_14
https://doi.org/10.1007/978-1-4939-9777-0_14
Autor:
Roger Alison, Julia F.M. Baker, Lise Bertrand, Pamela E. Blackshear, Brad Blankenship, Gary Boorman, Suzanne Botts, Michael Boyle, Alys Bradley, Danielle L. Brown, Mark F. Cesta, Vivian Chen, Phaedra Cole, Michelle C. Cora, Darlene Dixon, Dale G. Dunn, Johnnie J. Eighmy, Susan A. Elmore, Michael R. Elwell, Scot L. Eustis, Pierluigi Fant, Stacey L. Fossey, John R. Foster, Denzil Frost, Silvia Guionaud, D. Greg Hall, Gordon C. Hard, Adam Hargreaves, Ronald A. Herbert, Kyathanahalli S. Janardhan, Michael P. Jokinen, Ken Latimer, Joel R. Leininger, Régis Masson, Jenny McKay, Mark G. Mense, Rodney A. Miller, Shunji Nakatsuji, Arun R. Pandiri, Nicola Parry, Deepa B. Rao, Marlon C. Rebelatto, Amera K. Remick, Thomas J. Rosol, Aude Roulois, Melissa Schutten, John Curtis Seely, Alok K. Sharma, Steven D. Sorden, Catherine Sutcliffe, Andrew W. Suttie, Kathleen A. Szabo, Gregory S. Travlos, Takeki Uehara, John L. Vahle, Justin D. Vidal, Katharine M. Whitney, Jyoji Yamate, Katsuhiko Yoshitomi, Katsuhiko Yoshizawa, Bevin Zimmerman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fbc2cbcd3b2d821621dbb8fdbd177b3
https://doi.org/10.1016/b978-0-12-391448-4.00043-5
https://doi.org/10.1016/b978-0-12-391448-4.00043-5
This chapter addresses skeletal muscle pathology in laboratory rats. Normal skeletal muscle, degenerative conditions and disorders, myocyte regeneration, congenital anomalies, nutritional disorders, as well as various types of lesions and toxic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b949b3b68e4b1ce80f9fc366b977cec2
https://doi.org/10.1016/b978-0-12-391448-4.00017-4
https://doi.org/10.1016/b978-0-12-391448-4.00017-4
Autor:
Yan, Jin, Arie, Regev, Jeanelle, Kam, Krista, Phipps, Claire, Smith, Judith, Henck, Kristina, Campanale, Leijun, Hu, D Greg, Hall, Xiao Yan, Yang, Masako, Nakano, Terry Ann, McNearney, Jack, Uetrecht, William, Landschulz
Publikováno v:
British journal of clinical pharmacology. 84(1)
LY3031207, a novel microsomal prostaglandin E synthase 1 inhibitor, was evaluated in a multiple ascending dose study after nonclinical toxicology studies and a single ascending dose study demonstrated an acceptable toxicity, safety and tolerability p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05f45b02bca58b4d36a421cdcb82b176
https://pubmed.ncbi.nlm.nih.gov/28865237
https://pubmed.ncbi.nlm.nih.gov/28865237
Autor:
Holly W. Smith, D. Greg Hall, Bradley W. Main, Michael L. Pritt, H.-Y. Cindy Lee, Wherly P. Hoffman, Bradley L. Ackermann, A. Eric Schultze
Publikováno v:
Toxicologic Pathology. 39:576-588
The authors compared the mortality and cardiac biomarker responses in three outbred stocks of Sprague Dawley rats (CD/IGS, Sasco, Harlan) treated with isoproterenol hydrochloride. Cardiac injury was confirmed by histologic evaluation, and increases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d3ba43785b83e8859fa6d9da174705
https://doi.org/10.1177/0192623311402219
https://doi.org/10.1177/0192623311402219
Publikováno v:
Toxicologic Pathology. 39:58-65
For many pathologists, neuropathology is intimidating. Practical approaches for nervous tissue histologic evaluations to meet both routine and advanced study designs can lead to rewarding neuropathology efforts. Cost-effective, high-quality histologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1c67ee520f182c40a1ce6e8dd3aa84
https://doi.org/10.1177/0192623310391480
https://doi.org/10.1177/0192623310391480
Autor:
D. Greg Hall, George Stoica
Publikováno v:
Journal of Bone and Mineral Research. 9:221-230
Risedronate (NE-58095) is a third-generation bisphosphonate with very potent antiresorptive activity but few toxic effects. The purpose of this work was to evaluate the effect of risedronate treatment on bone metastases produced in a rat breast cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4330c75105888b523dad88ef767763
https://doi.org/10.1002/jbmr.5650090211
https://doi.org/10.1002/jbmr.5650090211
Publikováno v:
Toxicologic Pathology. 36:932-943
Since there is limited information in the literature, the purpose of this study was to investigate clinical signs, morphology, and temporal progression of lesions from Days 3 to 168 in a kainic acid (KA)-induced Fischer-344 (F-344) rat model of mesia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3871223f63f6993eb144122676404bf
https://doi.org/10.1177/0192623308326093
https://doi.org/10.1177/0192623308326093