Zobrazeno 1 - 10
of 122
pro vyhledávání: '"D. Godeneche"'
Autor:
Jean-Claude Madelmont, M. C. Dessalles, Jean-Claude Maurizis, Annie Veyre, D. Godeneche, N. Radembino, Pierre Labarre, J. L. Chabard, P. Gayral, Maryse Rapp, J. H. Trouvin, G. Mahuzier, P. Loiseau
Publikováno v:
Xenobiotica. 27:73-85
1. The tissue distribution and metabolism of a new filaricidal agent P903 (N-[(2-phenylethynyl)sulfonyl]morpholine) were studied in rat. 2. After s.c. administration of 14C and 13C P903, the Tmax in the blood was observed on day 2. Elimination was sl
Autor:
C. Cussac, R. G.-Gaudreault, Annie Veyre, Jean-Claude Madelmont, Jean-Claude Maurizis, M. Azim, D. Godeneche, Maryse Rapp
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:1079-1082
Le 2-chloroethy isocyanate a ete marque par 14C ou 13C sur le groupe carbonyl a partir de l'acide 3-chloropropionique 14C ou 13C afin de realiser le marquage du 4-terbutyl [3-(2-chloroethyl ureido] benzene). The labelling of 2-chloroethyliscyanate wi
Autor:
J. M. Dupuy, Annie Veyre, J. Sauzieres, Maryse Rapp, Jean-Claude Maurizis, Pierre Labarre, C. Cussac, J. L. Chabard, D. Godeneche, Jean-Claude Madelmont, J. P. Baudry
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:793-800
O6 Benzyl N acetyl guanosine a new inhibitor of O6 Alkyl Guanine transferase (O6AGT) was labelled by 14C and 13C on the benzyl methylen group in order to realize a pharmacokinetic study on nude mice grafted with human tumors. The labelling yield calc
Publikováno v:
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes. 43:425-436
Several cationic or neutral technetium-nitrido complexes of Schiff bases [for which 5-methyl 3-(2-hydroxyphenyl methylene) dithiocarbazate (L1) was a prototype], bis-aminoethanethiol (BAT-TM) and macrocyclic amines were prepared. We report here, the
Autor:
C, Cussac, M, Rapp, E, Mounetou, J C, Madelmont, J C, Maurizis, D, Godeneche, J M, Dupuy, J, Sauzieres, J P, Baudry, A, Veyre
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(3)
The exposure of cells to O6-methylguanine or O6-benzylguanine is known to reduce the enzymatic activity of O6-alkylguanine-DNA alkyltransferase, which leads to a sensitivity enhancement to chloroethylnitrosourea cytotoxic effects. The main disadvanta
Autor:
F, Gachon, P, Labarre, D, Godeneche, M F, Moreau, J, Papon, J C, Madelmont, A, Veyre, G, Gaillard
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(4)
The disposition and metabolism of two 14C-labeled species of Mitozolomide (Mz) were studied in healthy and in B16 melanoma-bearing mice after po administration of a 40 mg/kg dose. Urine was the main elimination route of the radioactivity derived from
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(1)
Urine is the major route of excretion of N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]-N'-nitrosourea (CMSOEN2), N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N'-nitrosourea (CMSO2EN2), and their metabolites in the rat. Labeling the two compounds w
Autor:
H. Sentenac-Roumanou, T. Hulot, P. Demerseman, A. Veyre, H. Garrigue, C. Nicolas, Jean-Claude Madelmont, Jean-Claude Maurizis, X. Morge, D. Godeneche
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 20(7)
1. The dispositions of two acetylcholinesterase reactivators, pyrimidoxime and HI6, labelled with 14C on the oxime group, have been studied in normal rats and rats poisoned by the organophosphates Soman and A4. 2. For both compounds, and for healthy
Publikováno v:
Biochemical Pharmacology. 24:1303-1308
The absorption, distribution and elimination of N,N-2- dichloro e tyl p -amino-4, phenyl butyric acid, labelled with 14 C on three different positions, was studied in the rat. The compound was labelled on either the carbon of the carboxyl group, the
Autor:
D. Godeneche, F. Lapalus
Publikováno v:
Biochemical Pharmacology. 23:1195-1203
The effect of a new thyroid component, recently isolated from bovine thyroglobulin. on the respiration and swelling of rat liver mitochondria, has been studied. This product is an iodinated peptide, 3,5 diiodo- l -tyrosyl 3,5 diiodo- l -tyrosine (TT