Zobrazeno 1 - 10
of 146
pro vyhledávání: '"D. Given"'
Autor:
Man-Fung Yuen, Stephen Locarnini, Tien Huey Lim, Simone I. Strasser, William Sievert, Wendy Cheng, Alex J. Thompson, Bruce D. Given, Thomas Schluep, James Hamilton, Michael Biermer, Ronald Kalmeijer, Maria Beumont, Oliver Lenz, Filip De Ridder, Gavin Cloherty, Danny Ka-Ho Wong, Christian Schwabe, Kathy Jackson, Ching Lung Lai, Robert G. Gish, Edward Gane
Publikováno v:
Journal of Hepatology. 77:1287-1298
RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479448f9f509e9a64dd4d4daf760b90d
https://doi.org/10.1016/j.jhep.2022.07.010
https://doi.org/10.1016/j.jhep.2022.07.010
Autor:
Pavel Strnad, Mattias Mandorfer, Gourab Choudhury, William Griffiths, Christian Trautwein, Rohit Loomba, Thomas Schluep, Ting Chang, Min Yi, Bruce D. Given, James C. Hamilton, Javier San Martin, Jeffery H. Teckman
Publikováno v:
New England Journal of Medicine. 387:514-524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50c1d9c78bce2aea5bfaa9aa57acded
https://doi.org/10.1056/nejmoa2205416
https://doi.org/10.1056/nejmoa2205416
Publikováno v:
Ibis. 165:248-269
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a6b5f10644b322119d8c02ab218924
https://doi.org/10.1111/ibi.13117
https://doi.org/10.1111/ibi.13117
Akademický článek
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Publikováno v:
Viruses, Vol 13, Iss 4, p 581 (2021)
Chronic hepatitis B infection remains a globally important cause of morbidity and mortality and has recently undergone a renaissance in therapeutic interest with increased pre-clinical and clinical testing of new drug classes. One of the first new cl
Externí odkaz:
https://doaj.org/article/b1b9ef9726d146579ad1ded7c78beef5
Autor:
Christine I. Wooddell, Man-Fung Yuen, James A. Hamilton, Danny Ka-Ho Wong, Ching-Lung Lai, Regina Cheuk-Lam Lo, Carlo Ferrari, Lung-Yi Mak, Robert G. Gish, Bruce D. Given, T. Schluep, Stephen Locarnini
Publikováno v:
Gut. 71:789-797
ObjectiveWe examined the serological, virological (in serum and liver) and histological profiles in chronic hepatitis B virus (HBV) patients during and after completion of multiple dose (MD) ARC-520.DesignThe present phase 1b study was a multidose, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee8d34e8e68894a2dad310057efc5e3
https://doi.org/10.1136/gutjnl-2020-323445
https://doi.org/10.1136/gutjnl-2020-323445
Autor:
Christian Trautwein, Mattias Mandorfer, Christianson, Jeffery H. Teckman, Bruce D. Given, N. Rajicic, G Choudhury, Alice M Turner, William J.H. Griffiths, James D. Hamilton, Pavel Strnad, J San Martin
Publikováno v:
37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503f31dd0667f51b629cbdff7cf24d2f
https://doi.org/10.1055/s-0040-1721947
https://doi.org/10.1055/s-0040-1721947
Autor:
Gerald F. Watts, James D. Hamilton, Christian Schwabe, Robert A. Hegele, Stacey Melquist, Bruce D. Given, David R. Sullivan, N. Rajicic, Ira J. Goldberg, John M. Baker, Peter M. Clifton, Christie M. Ballantyne, Patrick Gladding, Russell S. Scott, Joshua W. Knowles, Daniel Gaudet, Javier San Martin, Ting Chang
Publikováno v:
Circulation. 142
Background: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride (TG) and lipoprotein (LP) metabolism by inhibiting liver and endothelial LP lipases and reduces plasma LDL-C. In Phase 1 Study AROANG1001 (NCT03747224), single and multiple dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0243379c3714387a6022cff1bb8daa06
https://doi.org/10.1161/circ.142.suppl_3.15751
https://doi.org/10.1161/circ.142.suppl_3.15751