Zobrazeno 1 - 10
of 301
pro vyhledávání: '"D. Gitler"'
Autor:
D. Halperin, A. Stavsky, R. Kadir, M. Drabkin, O. Wormser, Y. Yogev, V. Dolgin, R. Proskorovski-Ohayon, Y. Perez, H. Nudelman, O. Stoler, B. Rotblat, T. Lifschytz, A. Lotan, G. Meiri, D. Gitler, O. S. Birk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Molecular mechanisms of attention-deficit hyperactivity disorder (ADHD) are not fully understood. Here the authors demonstrate a mutation in CDH2, encoding N-cadherin, that is associated with ADHD, and in a mouse model, delineate molecular electrophy
Externí odkaz:
https://doaj.org/article/b2ac786139e648b99e869dd21b3640f3
Autor:
Ehsan Dadgar-Kiani, Gregor Bieri, Ronald Melki, Aronee Hossain, Aaron D. Gitler, Jin Hyung Lee
Publikováno v:
Brain Stimulation, Vol 17, Iss 4, Pp 938-946 (2024)
Background: Many neurodegenerative disease treatments, such as deep brain stimulation for Parkinson's Disease, can alleviate symptoms by primarily compensating for circuit dysfunctions. However, the stimulation's effect on the underlying disease prog
Externí odkaz:
https://doaj.org/article/0c07d89464674a80ae063faf632be90e
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-5 (2024)
Abstract This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/a36e0957494842178bf60c68ee7aa96b
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/9628565cd0fc43dc81e3535e124ec483
Autor:
Jayson J. Smith, Seth R. Taylor, Jacob A. Blum, Weidong Feng, Rebecca Collings, Aaron D. Gitler, David M. Miller, III, Paschalis Kratsios
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113857- (2024)
Summary: Motor neurons (MNs) constitute an ancient cell type targeted by multiple adult-onset diseases. It is therefore important to define the molecular makeup of adult MNs in animal models and extract organizing principles. Here, we generate a comp
Externí odkaz:
https://doaj.org/article/953caea15b214f369b4db238ef9ec0ce
Autor:
Keren Lasker, Steven Boeynaems, Vinson Lam, Daniel Scholl, Emma Stainton, Adam Briner, Maarten Jacquemyn, Dirk Daelemans, Ashok Deniz, Elizabeth Villa, Alex S. Holehouse, Aaron D. Gitler, Lucy Shapiro
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
“Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. Here the authors show that PopZ condensate dynamics support cell division and using PopZ modular architecture, the tunable
Externí odkaz:
https://doaj.org/article/dea291a67d0a47ba85a97b024b6dede1
Autor:
Rui Tang, Christopher W Murray, Ian L Linde, Nicholas J Kramer, Zhonglin Lyu, Min K Tsai, Leo C Chen, Hongchen Cai, Aaron D Gitler, Edgar Engleman, Wonjae Lee, Monte M Winslow
Publikováno v:
eLife, Vol 9 (2020)
Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell inte
Externí odkaz:
https://doaj.org/article/13a418d59ffc4122921111ddb10c3638
Autor:
Luke W. Bonham, Ethan G. Geier, Daniel W. Sirkis, Josiah K. Leong, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Suzee E. Lee, Virginia E. Sturm, Russell P. Sawyer, Adit Friedberg, Justin K. Ichida, Aaron D. Gitler, Leo Sugrue, Michael Cordingley, Walter Bee, Eckard Weber, Joel H. Kramer, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, John Ravits, Bruce L. Miller, Jennifer S. Yokoyama
Publikováno v:
The Journal of Neuroscience. 43:333-345
Hexanucleotide repeat expansion (HRE) withinC9orf72is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfdbe4480f987d12b252f86e4c33446
https://doi.org/10.1523/jneurosci.1448-22.2022
https://doi.org/10.1523/jneurosci.1448-22.2022
Autor:
Meiyan Jin, Gregory G. Fuller, Ting Han, Yao Yao, Amelia F. Alessi, Mallory A. Freeberg, Nathan P. Roach, James J. Moresco, Alla Karnovsky, Misuzu Baba, John R. Yates, III, Aaron D. Gitler, Ken Inoki, Daniel J. Klionsky, John K. Kim
Publikováno v:
Cell Reports, Vol 20, Iss 4, Pp 895-908 (2017)
Glycolysis is upregulated under conditions such as hypoxia and high energy demand to promote cell proliferation, although the mechanism remains poorly understood. We find that hypoxia in Saccharomyces cerevisiae induces concentration of glycolytic en
Externí odkaz:
https://doaj.org/article/b752bb911b674d1f981c2e863f279eb0
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 499-502 (2017)
Neurodegeneration is a feature of many debilitating, incurable diseases that are rapidly rising in prevalence, such as Parkinson's disease. There is an urgent need to develop new and more effective therapeutic strategies to combat these devastating d
Externí odkaz:
https://doaj.org/article/7c24eb324a7642f5b273c07b1dbb77af