Zobrazeno 1 - 10
of 63
pro vyhledávání: '"D. Ghelfi"'
Autor:
Shijie Huang, Arpan Bhattacharya, Mikel D. Ghelfi, Hong Li, Clark Fritsch, David M. Chenoweth, Yale E. Goldman, Barry S. Cooperman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Ataluren is the only nonsense suppressor drug currently approved for clinical use. Here, the authors determine where ataluren binds to the ribosome and how it inhibits termination at nonsense codons.
Externí odkaz:
https://doaj.org/article/52c6bd055f67489bb40a044bb577cd4f
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 242 (2023)
Premature termination codons (PTCs) account for ~12% of all human disease mutations. Translation readthrough-inducing drugs (TRIDs) are prominent among the several therapeutic approaches being used to overcome PTCs. Ataluren is the only TRID that has
Externí odkaz:
https://doaj.org/article/d59e387027ee41c0b0e2be0187997711
Autor:
Arpan Bhattacharya, Mikel D. Ghelfi, Xiaonan Cui, Clark Fritsch, Hong Li, Barry S. Cooperman, Yale E. Goldman
Publikováno v:
Biophysical Journal. 122:490a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c59422155ff3d69cedbfea8022541b9
https://doi.org/10.1016/j.bpj.2022.11.2618
https://doi.org/10.1016/j.bpj.2022.11.2618
Autor:
Saleem Y. Bhat, Mikel D. Ghelfi, Arpan Bhattacharya, Hong Li, Yale E. Goldman, Barry S. Cooperman
Publikováno v:
Biophysical Journal. 122:490a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9055f7d806fcc3865843ade227816e6a
https://doi.org/10.1016/j.bpj.2022.11.2619
https://doi.org/10.1016/j.bpj.2022.11.2619
Autor:
Shijie, Huang, Arpan, Bhattacharya, Mikel D, Ghelfi, Hong, Li, Clark, Fritsch, David M, Chenoweth, Yale E, Goldman, Barry S, Cooperman
Publikováno v:
Nature communications. 13(1)
Genetic diseases are often caused by nonsense mutations, but only one TRID (translation readthrough inducing drug), ataluren, has been approved for clinical use. Ataluren inhibits release factor complex (RFC) termination activity, while not affecting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa09626dd66d090a4e118b9ffb6f228f
https://pubmed.ncbi.nlm.nih.gov/35523781
https://pubmed.ncbi.nlm.nih.gov/35523781
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Nonsense mutations giving rise to premature stop codons (PSCs) cause many diseases, creating the need to develop safe and effective translational read-through–inducing drugs (TRIDs). The current best-characterized TRIDs are ataluren an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f348b73d7ec9822f6ee89004ef0806
http://europepmc.org/articles/PMC7812769
http://europepmc.org/articles/PMC7812769
Autor:
Arpan Bhattacharya, Shijie Huang, Mikel D. Ghelfi, Hong Li, Clark Fritsch, David M. Chenoweth, Barry S. Cooperman, Yale E. Goldman
Publikováno v:
Biophysical Journal. 121:203a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164587694b8d61f10f8133ccb18dae18
https://doi.org/10.1016/j.bpj.2021.11.1723
https://doi.org/10.1016/j.bpj.2021.11.1723
Autor:
A. Tatman, I. Van Mourik, A. Warren, A. Williams, W. Whitehouse, D. G. Murdoch Eaton, M. Darowski, J. Livingston, M. Mönkhoff, O. Bänziger, C. Morales, A. Müller, H-U. Bucher, S. Fanconi, László Németh, József Kovács, Ferenc Joó, Kristóf Füzesi, Sándor Pintér, Pál Megyeri, Mária A. Deli, Csongor S. Ábrahám, Rosa I. de la Ibarra, Navero J. L. Pérez, Córdoba A. Palacios, Santamaría E. Ulloa, Jabalquinto M. J. Velasco, Lezcano A. Romanos, L. Schleien Charles, W. Kuluz John, Barry Gelznan, Alan Pinto, B. Simma, R. Burger, M. Falk, J. Uehlinger, D. Ghelfi, P. Sacher, J. I. Sanchez, M. Miralies, Orbe G. de Gonzalez, V. Ramos, A. Manrrique, F. Mar, Frank Shann
Publikováno v:
Intensive Care Medicine. 22:S160-S162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7c5e6a1b701870b7ca70e13813ab551
https://doi.org/10.1007/bf03216373
https://doi.org/10.1007/bf03216373
Publikováno v:
European Journal of Pediatrics. 154:236-238
We report a newborn with respiratory distress and situs inversus totalis. The diagnosis of primary ciliary dyskinesia was confirmed by both ultrastructural and functional investigations. The immotile cilia syndrome was suspected because of respirator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622d55b53da6db479a3680d5d8bfcfb6
https://doi.org/10.1007/bf01954280
https://doi.org/10.1007/bf01954280
Autor:
D, Ghelfi
Publikováno v:
Therapeutische Umschau. Revue therapeutique. 57(7)
There are many causes leading to breathing disorders in children. In the newborn period the immature central regulation of breathing can result in a pattern with apneas and bradycardias most commonly seen in the very premature infant. Therefore, duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1264d2bd646f7fb2f4f8de4388a7cc95
https://pubmed.ncbi.nlm.nih.gov/10953655
https://pubmed.ncbi.nlm.nih.gov/10953655