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Akademický článek

Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents

Autor: Amy D. Gelinas, Tiong Kit Tan, Sai Liu, Javier G. Jaramillo, James Chadwick, Adam C. Harding, Chi Zhang, Brian E. Ream, Chelsea N. Chase, Matthew R. Otis, Thomas Lee, Daniel J. Schneider, William S. James, Nebojsa Janjic

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 370-382 (2023)

Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on human health, with infection mortality rates as high as 10%, and a crippling impact on the world economy. Despite numerous advances, there remains an urge

Externí odkaz: https://doaj.org/article/94161dc783b24b7ab274f1e5261a3624

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Akademický článek

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Many individual genetic risk loci associate with multiple diseases, but the molecular basis of these loci often remains unclear. Here, the authors provide a framework to reveal the genetic cross-disease associations at the PROCR vascular disease locu

Externí odkaz: https://doaj.org/article/06e0764427f642ea9f1647a016e4fe9d

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Akademický článek

Publisher Correction: Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)

Externí odkaz: https://doaj.org/article/1a0ca0f841d5435e8760059b3c401a54

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Akademický článek

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

Autor: Xiaoming Ren, Amy D. Gelinas, Ira von Carlowitz, Nebojsa Janjic, Anna Marie Pyle

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that

Externí odkaz: https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd

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Akademický článek

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Modified aptamers as reagents to characterize recombinant human erythropoietin products

Autor: Nebojsa Janjic, Zuben E. Sauna, Katarzyna I. Jankowska, William C. Chang, Amy D. Gelinas, Wojciech Jankowski, H.A. Daniel Lagassé, Joseph R. McGill

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

Reliable and reproducible monitoring of the conformational state of therapeutic protein products remains an unmet technological need. This need is amplified by the increasing number of biosimilars entering the drug development pipeline as many brande

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381b5800079fec40335ce3f73a5a5e5d
http://link.springer.com/article/10.1038/s41598-020-75713-2

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Modified nucleotides may have enhanced early RNA catalysis

Autor: Larry Gold, Nebojsa Janjic, Edward N. Brody, Guillot Jessica, Steven K. Wolk, David P. Astling, Wesley S. Mayfield, Amy D. Gelinas

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f021658d0f6db386f0081e09dbe83f1
https://doi.org/10.1073/pnas.1809041117

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