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Autor: Jayne D. Gassman

Publikováno v: Journal of Prevention & Intervention in the Community. 21:65-78

SUMMARY As the elder population increases, providers and clinicians are seeing older patients with greater frequency. The present article describes the family issues that arise with older patients with a chronic illness. The problems are presented in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f6befef2f2bc4804db57af487a376b
https://doi.org/10.1300/j005v21n01_05

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Search for the two-phonon octupole vibrational state in 208Pb

Autor: Stephen Sanders, R. G. Henry, M. P. Carpenter, T. L. Khoo, C. J. Lister, T. Lauritsen, B. Crowell, D. Nisius, E. F. Moore, R. V. F. Janssens, D. Gassman, D. J. Blumenthal, H. Amro, M.W. Drigert, I. Ahmad, W. F. Henning

Publikováno v: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 99:308-311

We performed an experiment to search for the two-phonon octupole vibrational state in {sup 208}Pb. Thick targets of {sup 208}Pb, {sup 209}Bi, {sup 58,64}Ni, and {sup 160}Gd were bombarded with 1305 MeV beams of were bombard {sup 208}Pb supplied by AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35ae22d621f8f68c33ff713dd35c4a56
https://doi.org/10.1016/0168-583x(94)00687-3

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Small Molecule Suppressors of Drosophila Kinesin Deficiency Rescue Motor Axon Development in a Zebrafish Model of Spinal Muscular Atrophy

Autor: Christine E. Beattie, Le T. Hao, Leena Bhoite, Andrew D. Gassman, John Manfredi, Chad Bradford, Chi-Bin Chien

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e74325 (2013)

Proximal spinal muscular atrophy (SMA) is the most common inherited motor neuropathy and the leading hereditary cause of infant mortality. Currently there is no effective treatment for the disease, reflecting a need for pharmacologic interventions th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade8907953768142d9421b7a57b070ca
https://doi.org/10.1371/journal.pone.0074325

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Abstract 3526: Coadministration of nicotinic acid with the Nampt inhibitor MPC-9528 enhances antitumor activity in Naprt deficient cancer cells in culture and in xenografts

Autor: Ryan T. Terry-Lorenzo, Damon I. Papac, Rosann Robinson, Tracey C. Fleischer, Daniel M. Cimbora, Lynn DeMie, Andrew D. Gassman, J. Jay Boniface, Vijay Baichwal, Thomas B. Douce, Ashley Peterson, Robert O. Carlson

Publikováno v: Cancer Research. 71:3526-3526

Background: The tumoricidal small molecule MPC-9528 is a picomolar inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt catalyzes the first and rate-limiting step in NAD synthesis from nicotinamide. Nicotinic acid phosphoribosyltransfer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e67537febe6cb2a98883e170d50ad881
https://doi.org/10.1158/1538-7445.am2011-3526

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Abstract 577: Basal NAD levels and Nampt expression correlate with in vitro and in vivo sensitivity of tumor cell lines to the Nampt inhibitor MPC-9528

Autor: Damon I. Papac, Ryan T. Terry-Lorenzo, Vijay Baichwal, Jeff S. Flick, Tracey C. Fleischer, Andrew D. Gassman, J. Jay Boniface, Ashley Peterson, Lynn DeMie, Jeremy P. Green, Robert O. Carlson, Rosann Robinson, Daniel M. Cimbora, Siavash Ghaffari

Publikováno v: Cancer Research. 71:577-577

Background: MPC-9528 is a potent and selective inhibitor of the NAD biosynthetic enzyme nicotinamide phosphoribosyltransferase (Nampt). Inhibition of Nampt by MPC-9528 causes depletion of cellular NAD followed by a decrease in ATP and cell death. Can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e11d2dcf73c9518e51ab6eb7d198568d
https://doi.org/10.1158/1538-7445.am2011-577

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Line-critical point determining and point distinguishing graphs

Autor: Larry D. Gassman, R. C. Entringer

Publikováno v: Discrete Mathematics. 10(1):43-55

Sumner defined a graph to be point determining if and only if distinct points have distinct neighborhoods and he has characterized connected line-critical point determining graphs. Here a short alternate proof of his characterization is provided and

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