Zobrazeno 1 - 10
of 46
pro vyhledávání: '"D. Gareth R. Evans"'
Autor:
Robert D. Morgan, George J. Burghel, Helene Schlecht, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Joseph Shaw, Sudha Desai, Gordon C. Jayson, Emma R. Woodward, D. Gareth R. Evans
Publikováno v:
Cancers, Vol 16, Iss 1, p 177 (2023)
Patients diagnosed with epithelial ovarian cancer may undergo reflex tumour BRCA1/2 testing followed by germline BRCA1/2 testing in patients with a positive tumour test result. This testing model relies on tumour BRCA1/2 tests being able to detect al
Externí odkaz:
https://doaj.org/article/3122f59188784a6ab441ba4e0329ec9f
Autor:
Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Helene Schlecht, Gordon C. Jayson, D. Gareth R. Evans
Publikováno v:
Cancers, Vol 15, Iss 3, p 730 (2023)
Women diagnosed with non-mucinous high-grade epithelial ovarian cancer (EOC) in England are often reflex-tested for germline and tumour BRCA1/2 variants. The value of germline BRCA1/2 testing in women diagnosed aged ≥80 is questionable. We performe
Externí odkaz:
https://doaj.org/article/226d8028d5794a148682355578cb1be9
Autor:
Yaohua Yang, Xiang Shu, Xiao-ou Shu, Manjeet K. Bolla, Sun-Seog Kweon, Qiuyin Cai, Kyriaki Michailidou, Qin Wang, Joe Dennis, Boyoung Park, Keitaro Matsuo, Ava Kwong, Sue Kyung Park, Anna H. Wu, Soo Hwang Teo, Motoki Iwasaki, Ji-Yeob Choi, Jingmei Li, Mikael Hartman, Chen-Yang Shen, Kenneth Muir, Artitaya Lophatananon, Bingshan Li, Wanqing Wen, Yu-Tang Gao, Yong-Bing Xiang, Kristan J. Aronson, John J. Spinell, Manuela Gago-Dominguez, Esther M. John, Allison W. Kurian, Jenny Chang-Claude, Shou-Tung Chen, Thilo Dörk, D. Gareth R. Evans, Marjanka K. Schmidt, Min-Ho Shin, Graham G. Giles, Roger L. Milne, Jacques Simard, Michiaki Kubo, Peter Kraft, Daehee Kang, Douglas F. Easton, Wei Zheng, Jirong Long
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 203-211 (2019)
Background: We previously conducted a systematic field synopsis of 1059 breast cancer candidate gene studies and investigated 279 genetic variants, 51 of which showed associations. The major limitation of this work was the small sample size, even poo
Externí odkaz:
https://doaj.org/article/ee7f8f21d88148368f71eaa0c03f16fe
Autor:
Mev Dominguez-Valentin, D. Gareth R. Evans, Sigve Nakken, Hélène Tubeuf, Daniel Vodak, Per Olaf Ekstrøm, Anke M. Nissen, Monika Morak, Elke Holinski-Feder, Alexandra Martins, Pål Møller, Eivind Hovig
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 16, Iss 1, Pp 1-14 (2018)
Abstract Background In kindreds carrying path_BRCA1/2 variants, some women in these families will develop cancer despite testing negative for the family’s pathogenic variant. These families may have additional genetic variants, which not only may i
Externí odkaz:
https://doaj.org/article/6deea8d410b04800addd158ba179a27c
Autor:
Robert D. Morgan, Andrew R. Clamp, Daniel J. White, Marcus Price, George J. Burghel, W. David J. Ryder, Reem D. Mahmood, Alexander D. Murphy, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Chelsey Wheeler, Emma Buckley, Joanna Truelove, Georgia King, Yasmina Ainaoui, Sanjeev S. Bhaskar, Joseph Shaw, D. Gareth R. Evans, Bedirhan Kilerci, Simon P. Pearce, Gerard Brady, Caroline Dive, James P.B. O'Connor, Andrew J. Wallace, Dominic G. Rothwell, Richard J. Edmondson, Gordon C. Jayson
Publikováno v:
Clinical Cancer Research. :OF1-OF10
Purpose: A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.
Autor:
D. Gareth R. Evans, Elke M. van Veen, Elaine F. Harkness, Adam R. Brentnall, Susan M. Astley, Helen Byers, Emma R. Woodward, Sarah Sampson, Jake Southworth, Sacha J. Howell, Anthony J. Maxwell, William G. Newman, Jack Cuzick, Anthony Howell
Publikováno v:
Genetics in Medicine. 24:1485-1494
There is great promise in breast cancer risk stratification to target screening and prevention. It is unclear whether adding gene panels to other risk tools improves breast cancer risk stratification and adds discriminatory benefit on a population ba
Autor:
Robert D Morgan, Andrew R Clamp, Bethany M Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S Sundar, Shibani Nicum, James D Brenton, Rebecca S Kristeleit, Susana Banerjee, Iain A McNeish, Jonathan A Ledermann, Stephen S Taylor, D Gareth R Evans, Gordon C Jayson
Publikováno v:
Morgan, R D, Clamp, A R, Barnes, B M, Timms, K, Schlecht, H, Yarram-Smith, L, Wallis, Y, Valganon-Petrizan, M, Macmahon, S, White, R, Morgan, S, Mckenna, S, Hudson, E, Tookman, L, George, A, Manchanda, R, Sundar, S S, Nicum, S, Brenton, J D, Kristeleit, R S, Banerjee, S, Mcneish, I A, Ledermann, J A, Taylor, S S, Evans, D G & Jayson, G C 2023, ' Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study ', International Journal of Gynecological Cancer . https://doi.org/10.1136/ijgc-2022-004211
ObjectiveOlaparib plus bevacizumab maintenance therapy improves survival outcomes in women with newly diagnosed, advanced, high-grade ovarian cancer with a deficiency in homologous recombination. We report data from the first year of routine homologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb793cc9d756983a33fbb917e7372e8
https://doi.org/10.1136/ijgc-2022-004211
https://doi.org/10.1136/ijgc-2022-004211
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
BRCA2 reversion mutation detected in cell-free circulating DNA from patient 16.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8190683682e17f23bf7a91a183e796
https://doi.org/10.1158/1078-0432.22490383.v1
https://doi.org/10.1158/1078-0432.22490383.v1
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Purpose:A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383a4bd467a2e8ab9634c5efb3f01674
https://doi.org/10.1158/1078-0432.c.6533146
https://doi.org/10.1158/1078-0432.c.6533146
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Supplementary Methodology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac4b273d975d5742c671ed36cc435ae
https://doi.org/10.1158/1078-0432.22490380
https://doi.org/10.1158/1078-0432.22490380