Alpha-synuclein aggregates are phosphatase resistant

Autor: S. G. Choi, T. Tittle, D. Garcia-Prada, J. H. Kordower, R. Melki, B. A. Killinger

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)

Abstract Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called synucleinopathies. Phosphorylation of αsyn at serine 129 (PSER129) was considered rare in

Externí odkaz: https://doaj.org/article/a81cab8e30a24d71b7ad9055905be9fb

Alpha-synuclein aggregates are phosphatase resistant.

Autor: Choi SG; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Tittle T; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Garcia-Prada D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kordower JH; ASU-Banner Neurodegenerative Disease Research Center and School of Life Sciences, Arizona State University, Tempe, AZ, USA., Melki R; Institut Francois Jacob (MIRCen), CEA and Laboratory of Neurodegenerative Diseases, CNRS, Fontenay-Aux-Roses Cedex, France., Killinger BA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 09. Date of Electronic Publication: 2024 Apr 09.