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Both CCK-A and CCK-B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands

Autor: D. G. Witte, Bruce R. Bianchi, Chun Wel Lin, C. A. W. Wolfram, Thomas R. Miller

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 262:G1113-G1120

We evaluated the affinity of cholecystokinin octapeptide (CCK-8), gastrin, and subtype-selective CCK agonists for CCK/gastrin receptors and compared it with the ability of these peptides to stimulate phosphoinositide (PI) hydrolysis and pepsinogen re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97139c296d99fefe666e23ca6aba92c
https://doi.org/10.1152/ajpgi.1992.262.6.g1113

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In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties

Publikováno v: British journal of pharmacology. 157(1)

The histamine H4 receptor is widely expressed in cells of immune origin and has been shown to play a role in a variety of inflammatory processes mediated by histamine. In this report, we describe the in vitro and in vivo anti-inflammatory properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02b286cb3e4668f23aebae4000f7d7c3
https://pubmed.ncbi.nlm.nih.gov/19413570

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Actions of A-131701, a novel, selective antagonist for alpha-1A compared with alpha-1B adrenoceptors on intraurethral and blood pressure responses in conscious dogs and a pharmacodynamic assessment of in vivo prostatic selectivity

Autor: A A, Hancock, M E, Brune, D G, Witte, K C, Marsh, S, Katwala, I, Milicic, L M, Ireland, D, Crowell, M D, Meyer, J F, Kerwin

Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(2)

A-131701 (3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b, hexahydro-[1H]-benz[e]isoindol-2-yl)ethyl]pyrido [3',4': 4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione) is a novel compound previously shown to be selective for alpha-1a sites compared with alpha-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::824a184a7c7bfae7b8baf3ea42e097b1
https://pubmed.ncbi.nlm.nih.gov/9580607

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Relationships between pharmacokinetics and blockade of agonist-induced prostatic intraurethral pressure and mean arterial pressure in the conscious dog after single and repeated daily oral administration of terazosin

Autor: D G, Witte, M E, Brune, S P, Katwala, I, Milicic, J F, Kerwin, A A, Hancock

Publikováno v: The Journal of pharmacology and experimental therapeutics. 282(2)

The purpose of this study was to determine the potency and selectivity of the alpha-1 adrenergic receptor antagonist terazosin based on relationships between plasma concentrations and blockade of intraurethral pressure (IUP) and mean arterial pressur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9617350997aded144f37fd3d278c4132
https://pubmed.ncbi.nlm.nih.gov/9262356

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Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells

Autor: C W, Lin, T R, Miller, D G, Witte, B R, Bianchi, M, Stashko, A M, Manelli, D E, Frail

Publikováno v: Molecular pharmacology. 47(1)

Dopamine (DA) D1 receptors are generally known to couple only to Gs and cAMP production. Recently, D1 receptors expressed in mouse Ltk- cells have been shown to induce cAMP production, phosphoinositide (PI) hydrolysis, and calcium mobilization [Mol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::199be5031cb20c2947d9181b672d2565
https://pubmed.ncbi.nlm.nih.gov/7838121

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Novel CCK analogues and bombesin: a detailed analysis between phosphoinositide breakdown and high-dose inhibition of pancreatic enzyme secretion in three rodent species

Autor: B R, Bianchi, T R, Miller, D G, Witte, C W, Lin

Publikováno v: The Journal of pharmacology and experimental therapeutics. 268(2)

Cholecystokinin octapeptide (26-33) (CCK-8) stimulates pancreatic amylase secretion in a biphasic manner. Amylase secretion is stimulated in a dose-dependent manner up to a maximal level, but reduced secretion is observed at supramaximal concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf497dd1c2aac208b40f38a2d3301d6a
https://pubmed.ncbi.nlm.nih.gov/7509394

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Cloning and characterization of a truncated dopamine D1 receptor from goldfish retina: stimulation of cyclic AMP production and calcium mobilization

Autor: D E, Frail, A M, Manelli, D G, Witte, C W, Lin, M E, Steffey, R G, Mackenzie

Publikováno v: Molecular pharmacology. 44(6)

Receptors for dopamine are present on horizontal cells of fish retina that are linked to the activation of adenylate cyclase. In the present study, the goldfish (Carassius auratus) gene that encodes these receptors, referred to as gfD1, was isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::082f8232bf755503d18347f45f3fd506
https://pubmed.ncbi.nlm.nih.gov/8264547

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Identification and characterization of type A endothelin receptors in MMQ cells

Autor: J R, Wu-Wong, W, Chiou, S R, Magnuson, D G, Witte, C W, Lin

Publikováno v: Molecular pharmacology. 44(2)

Recently the identification of endothelin (ET) receptors and ET in the pituitary gland has induced much interest in studying the potential role of ET in neuroendocrine regulation. MMQ, isolated from rat pituitary, is a prolactin-secreting cell line.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32d48cf19605556c2200649e80907a07
https://pubmed.ncbi.nlm.nih.gov/8355666

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