Výsledky vyhledávání - "D. G. Semizarov"

Autor: D. G. Semizarov, L. S. Viktorova, Yu. A. Sharkin, Marina K. Kukhanova

Publikováno v: Russian Journal of Bioorganic Chemistry. 27:340-348

Several modified nucleoside 5"-triphosphates containing adenine-mimicking pyrimidine derivatives as an aglycone were synthesized. The study of substrate properties of these compounds towards DNA-synthesizing enzymes showed their ability of being inco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d88a5dd68b4ff04b65e12525fa3a6c
https://doi.org/10.1023/a:1012348515833

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[Synthesis and substrate properties of modified nucleoside 5'-triphosphates mimicking dATP in the reactions of DNA synthesis catalyzed by DNA polymerases]

Autor: Iu A, Sharkin, D G, Semizarov, L S, Viktorova, M K, Kukhanova

Publikováno v: Bioorganicheskaia khimiia. 27(5)

Several modified nucleoside 5'-triphosphates were synthesized containing adenine-mimicking pyrimidine derivatives as an aglycone. The study of substrate properties of these compounds towards DNA-synthesizing enzymes showed their ability of being inco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0906498f0c9c7937a6509b04bfd0003d
https://pubmed.ncbi.nlm.nih.gov/11641913

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[Synthesis and some biochemical properties of phosphonyl acyclic analogs of 2'-deoxyadenosine nucleotides]

Autor: D V, Malakhov, D G, Semizarov, M V, Ias'ko

Publikováno v: Bioorganicheskaia khimiia. 21(7)

9-[2-(phosphonomethylcarbonylamino)ethyl]adenine, 9-[(2-phosphonoethyl)aminocarbonylmethyl]adenine, 9-[2-[(2-phosphonoethyl)carbonylamino]ethyl]adenine, and their diphosphates were synthesized. All three diphosphates were shown to incorporate into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::805273731078785855e40796748fbfd2
https://pubmed.ncbi.nlm.nih.gov/7488270

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[New nucleotide inhibitors of human DNA polymerase alpha]

Autor: D G, Semizarov, M V, Ias'ko, M K, Kukhanova, A A, Kraevskiĭ

Publikováno v: Molekuliarnaia biologiia. 29(3)

2'-Deoxythymidine 5'-triphosphate and 2'-deoxyadenosine 5'-triphosphate analogs containing a methylene group between the alpha phosphorus and 5' oxygen were synthesized. The substrate properties of these compounds toward some mammalian DNA polymerase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22cd4ff59abf233b841d251efbe0e092
https://pubmed.ncbi.nlm.nih.gov/8552070

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[Study of reverse transcriptase selectivity. Substrate properties of new 2',3'-unsaturated acyclic nucleotide analogs]

Autor: E A, Shirokova, A V, Shipitsyn, D G, Semizarov

Publikováno v: Molekuliarnaia biologiia. 29(2)

A new series of nucleotide analogs, (Z)-pyrophosphoryl (phosphonyloxymethyl) but-2-enyl derivatives of pyrimidines and purines, was synthesized. Their substrate and inhibitory properties toward some DNA polymerases and reverse transcriptases were eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57c6e614cd0e731fffd8423212d91a7b
https://pubmed.ncbi.nlm.nih.gov/7540255

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New modified substrates for discriminating between human DNA polymerases alpha and epsilon

Autor: M V, Jasko, D G, Semizarov, L S, Victorova, Mozzherin DJu, A A, Krayevsky, M K, Kukhanova

Publikováno v: FEBS letters. 357(1)

Two 2'-deoxynucleoside 5'-alpha-methylenephosphonyl-beta, gamma-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase alpha from human placenta. Meanwhile, they were not recognized by DNA polymerase epsilon and be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::841508e3b2595af1503f6b23ebf36e65
https://pubmed.ncbi.nlm.nih.gov/7528146

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[3'-(Tetrazol-2'-yl-3'-deoxythymidine and its 5'-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2'-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases]

Autor: V A, Ostrovskiĭ, E P, Studentsov, V S, Poplavskiĭ, N V, Ivanov, G V, Gurskaia, V E, Zavodnik, M V, Ias'ko, D G, Semizarov

Publikováno v: Bioorganicheskaia khimiia. 21(1)

5''-Derivatives of 3'-(tetrazole-2''-yl)-3'-deoxythymidines were synthesized by interaction of 5'-benzoyl-2',3'-anhydrothymidine with tetrazole or its 5-derivatives followed by debenzoylation. Structures of two of them, 3'-(tetrazole-2''-yl)-3'-deoxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fca37f9a0283df4a720eee851ea8cf1c
https://pubmed.ncbi.nlm.nih.gov/7710425

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Selectivity of DNA polymerases toward alpha and beta nucleotide substrates of D and L series

Autor: D G, Semizarov, L S, Victorova, N B, Dyatkina, M, von Janta-Lipinski, A A, Krayevsky

Publikováno v: FEBS letters. 354(2)

The substrate properties of four carbocyclic D and L nucleoside 5'-triphosphate analogs toward HIV and AMV reverse transcriptases and terminal deoxynucleotidyl transferase were evaluated. The compounds of the D-beta and L-beta series were found to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a1086d934533b43cb6d9289f07ec24f
https://pubmed.ncbi.nlm.nih.gov/7525353

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[Modified nucleoside-5'-triphosphates with an additional conjugated through the 2'-3'-fused ring as DNA polymerase substrates]

Autor: D G, Semizarov, L S, Viktorova, A A, Kraevskiĭ, M K, Kukhanova

Publikováno v: Molekuliarnaia biologiia. 28(1)

5'-Triphosphates of 1-(2',3'-epithio-2',3'-dideoxy-beta-D-lyxofuranosyl) thymine, 1-(2',3'-epithio-2',3'-dideoxy-beta-D-ribofuranosyl) thymine and 2',3'-lyxoanhydrothymidine have been shown to be terminator substrates of human immunodeficiency virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2be432f01bff53505cf1a31ef0508ced
https://pubmed.ncbi.nlm.nih.gov/7511783

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