Výsledky vyhledávání - "D. G. Priest"

Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis

Autor: G. Jansen, Y. G. Assaraf, D. G. Priest, M. Bunni, M. Kool, I. Kathmann, J. H. Hooijberg, R. J. Scheper, B. A. C. Dijkmans, G. J. Kaspers, G. J. Peters

Publikováno v: Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171

Cellular folate homeostasis is essential to allow continuous use of reduced folate cofactors for a variety of biosynthetic processes including purine and pyrimidine biosynthesis, mitochondrial protein synthesis and amino acid biosynthesis. Beyond thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7e1c311b149fc56d5160ea6fe23b8fd
https://doi.org/10.1007/978-1-4615-0945-5_108

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Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors

Autor: C L, van der Wilt, H H, Backus, K, Smid, L, Comijn, G, Veerman, D, Wouters, D A, Voorn, D G, Priest, M A, Bunni, F, Mitchell, A L, Jackman, G, Jansen, G J, Peters

Publikováno v: Cancer research. 61(9)

Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) inhibitors, such as 5-fluorouracil (5FU) and the antifolates pemetrexed (MTA) and raltitrex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ccc83d5b5ae9179f10c9399e1935861
https://pubmed.ncbi.nlm.nih.gov/11325838

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Pharmacokinetic and pharmacodynamic evaluation of the glycinamide ribonucleotide formyltransferase inhibitor AG2034

Autor: H L, McLeod, J, Cassidy, R H, Powrie, D G, Priest, M A, Zorbas, T W, Synold, S, Shibata, D, Spicer, D, Bissett, Y K, Pithavala, M A, Collier, L J, Paradiso, J D, Roberts

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)

Glycinamide ribonucleotide formyltransferase (GARFT) is a component of the de novo purine synthesis pathway. AG2034 is a specific inhibitor of GARFT that was designed based on the GARFT crystal structure. In conjunction with Phase I studies at four c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb95df6ce971e27d00a6481a774811b8
https://pubmed.ncbi.nlm.nih.gov/10914709

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Accumulation of plasma reduced folates after folic acid administration

Autor: D G, Priest, J C, Schmitz, M A, Bunni

Publikováno v: Seminars in oncology. 26(2 Suppl 6)

The pharmacokinetics of folic acid, and resultant metabolites thereof, have been determined after administration orally and intravenously at 25 mg/m2 and 125 mg/m2. Saturation behavior was observed for uptake of folic acid into plasma and with regard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b94122bc8406e36c51e74428bd0b213d
https://pubmed.ncbi.nlm.nih.gov/10598553

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Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration

Autor: G, Jansen, H, Barr, I, Kathmann, M A, Bunni, D G, Priest, P, Noordhuis, G J, Peters, Y G, Assaraf

Publikováno v: Molecular pharmacology. 55(4)

Chinese hamster ovary PyrR100 cells display more than 1000-fold resistance to pyrimethamine (Pyr), a lipophilic antifolate inhibitor of dihydrofolate reductase. PyrR100 cells had wild-type DHFR activity, lost folate exporter activity, and had a 4-fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d061e323ce3e795d2f759d758da7f1c
https://pubmed.ncbi.nlm.nih.gov/10101035

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Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM

Autor: G, Pizzorno, B A, Moroson, A R, Cashmore, O, Russello, J R, Mayer, J, Galivan, M A, Bunni, D G, Priest, G P, Beardsley

Publikováno v: Cancer research. 55(3)

5,10-dideaza-5,6,7,8-terrahydrofolic acid (DDATHF) is a potent antiproliferative agent in cell culture systems and in vivo in a number of murine and human xenograft tumors. In contrast to classical antifolates, which are dihydrofolate reductase inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ce724b759dc1d0ac0627877813fe547
https://pubmed.ncbi.nlm.nih.gov/7834626

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Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity

Autor: J C, Schmitz, G B, Grindey, R M, Schultz, D G, Priest

Publikováno v: Biochemical pharmacology. 48(2)

To investigate the role of dietary folic acid in dideazatetrahydrofolate (DDATHF) sensitivity, reduced folates were estimated in plasma and tissue of mice following dietary depletion and repletion. Previous studies showed that DDATHF, a new folate an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce820b7afb45dd79f821f48ebeaba0a8
https://pubmed.ncbi.nlm.nih.gov/8053927

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