Výsledky vyhledávání - "D. G. Maloney"

Akademický článek

Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

Autor: S. Fiorenza, Y. Zheng, J. Purushe, T. J. Bock, J. Sarthy, D. H. Janssens, A. S. Sheih, E. L. Kimble, D. Kirchmeier, T. D. Phi, J. Gauthier, A. V. Hirayama, S. R. Riddell, Q. Wu, R. Gottardo, D. G. Maloney, J. Y. H. Yang, S. Henikoff, C. J. Turtle

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Chimeric antigen receptor-modified T cell (CAR-T) immunotherapy has revolutionised blood cancer treatment. Parsing the genetic underpinnings of T cell quality and CAR-T efficacy is challenging. Transcriptomics inform CAR-T state, but the nat

Externí odkaz: https://doaj.org/article/99952e45b80a494cbf0a1c52b7763252

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Anions and the anaesthetist

Autor: D. G. Maloney, R. S. Vaughan, I. R. Appadurai

Publikováno v: Anaesthesia. 57:140-154

Anions are the negative components of most chemical structures and play many important physiological and pharmacological roles that are of interest to the anaesthetist. Their relevance is reviewed with a particular emphasis on the inorganic anions (h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24b86ec8b759534f966169e176702719
https://doi.org/10.1046/j.1365-2044.2002.02274.x

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Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein

Autor: W M, Vuist, R, Levy, D G, Maloney

Publikováno v: Blood. 83:899-906

Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf27b27b06a1f2aa070cb4458952ab6
https://doi.org/10.1182/blood.v83.4.899.bloodjournal834899

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Monoclonal anti-idiotype antibody therapy of B-cell lymphoma: the addition of a short course of chemotherapy does not interfere with the antitumor effect nor prevent the emergence of idiotype-negative variant cells

Autor: D G, Maloney, S, Brown, D K, Czerwinski, T M, Liles, S M, Hart, R A, Miller, R, Levy

Publikováno v: Blood. 80:1502-1510

The Ig idiotype of B-cell lymphoma can be used as a tumor-specific target. Prior trials with monoclonal anti-idiotype antibodies alone and combined with alpha-interferon have shown significant antitumor activity. In some patients, idiotype-negative t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7e9e66080c0e6eb4b109c1917d9b5
https://doi.org/10.1182/blood.v80.6.1502.bloodjournal8061502

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