Výsledky vyhledávání - "D. G. MacPhee"

Mismatch repair as an important source of new mutations in non-dividing cells

Autor: D. G. MacPhee

Publikováno v: Experientia. 52(4)

This paper describes a mechanism which permits somatic cells to generate random mutations in the complete absence of cell proliferation. Knowledge of the existence of this mechanism should provide us with the basis for a better understanding of a num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d30e1bc612b04f9f8d825e6d0ffa0f
https://pubmed.ncbi.nlm.nih.gov/8620941

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Mismatch repair, somatic mutations, and the origins of cancer

Autor: D G, MacPhee

Publikováno v: Cancer research. 55(23)

This paper outlines the basic properties of a newly recognized pathway that should enable somatic cells to generate double-stranded mutations in the complete absence of cell proliferation. Recognition of the existence of this pathway provides us with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1149db8388e7d211eaa2744d70077cce
https://pubmed.ncbi.nlm.nih.gov/7585619

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Origins of spontaneous mutants: cellular strategies for controlling their formation in response to changing environments

Autor: D G, MacPhee

Publikováno v: Cytobios. 75(301)

Spontaneous and induced mutational events may not be as readily distinguishable as has been generally assumed. It is suggested that the later stages of the processes leading to the establishment of fixation of mutations may consist of a 'mutational p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49770e24f6d73d2b90fb790601055d64
https://pubmed.ncbi.nlm.nih.gov/8404031

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Precise excision of Tn10 in Salmonella typhimurium: effects of mutations in the polA, dam, mutH and mutB genes and of methionine or ethionine in the plating medium

Autor: L M, Hafner, D G, MacPhee

Publikováno v: Mutation research. 263(3)

Precise excision of Tn10 occurs at significantly elevated frequencies in cultures of the polA7 mutant strain of Salmonella typhimurium, is further increased in polA7 dam-1 and polA7 mutB strains and decreased in a polA7 mutH background. The numbers o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::152c331b011ab29f7ac36b1f49dac857
https://pubmed.ncbi.nlm.nih.gov/1648667

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Comparative mutagenicity of nitrofluoranthenes in Salmonella typhimurium TA98, TA98NR, and TA98/1,8DNP6

Autor: B. S. Shane, G. L. Squadrito, D. F. Church, W. A. Pryor, D. G. MacPhee

Publikováno v: Environmental and molecular mutagenesis. 17(2)

The nitration of fluoranthene, one of the most abundant polycyclic aromatic hydrocarbons (PAH) in diesel fuels, occurs in the laboratory under either electrophilic or free-radical conditions to give nitro-PAH. 3-Nitrofluoranthene (3-NF) is the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0c3aa2daa0d498957b35d8649387ca
https://pubmed.ncbi.nlm.nih.gov/2009868

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Fluctuation tests are more sensitive than plate tests in detection of chemicals which cause enhanced excision of transposon Tn10 in Salmonella typhimurium

Autor: L M, Hafner, D G, MacPhee

Publikováno v: Mutation research. 245(2)

Precise excision of transposon Tn10, as judged by reversion of Salmonella typhimurium strain LT2 trp1014::Tn10 to Trp+, was not detectably enhanced following exposure to 9-aminoacridine, 5-azacytidine or mitomycin C in conventional treat-and-plate as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::564cf852c632d1280a138acc6e52b850
https://pubmed.ncbi.nlm.nih.gov/2170837

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The Effect of Defined Lipopolysaccharide Core Defects upon Antibiotic Resistances of Salmonella typhimurium

Autor: R. J. Roantree, T.-T. Kuo, D. G. Macphee

Publikováno v: Journal of General Microbiology. 103:223-234

Antibiotic resistances of two sets of Salmonella typhimurium rfa transductants (along with those of their smooth pyrE + and cysE + sister transductants) were measured. One set was derived from a pyrE smooth LT2 parent and the other from a cysE smooth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e392603ba1b8050641e74e4ee0988d85
https://doi.org/10.1099/00221287-103-2-223

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