Zobrazeno 1 - 10
of 21
pro vyhledávání: '"D. G. Kaiser"'
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 25(8)
1. Over a broad range of tertiary N-methyl amines, whenever alkyl-nitrogen bond cleavage was observed, N-demethylation was also observed.2. Alkyl-nitrogen bond cleavage in rings, alkyl-nitrogen bond cleavage if the carbon of the N-dealkylation reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685a5796f99471ed4dbd4c46d22b9b05
https://pubmed.ncbi.nlm.nih.gov/8779224
https://pubmed.ncbi.nlm.nih.gov/8779224
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(3)
Following administration of a single oral dose (400 mg) or RS-ibuprofen (RS-IBP) to humans, a novel metabolite was isolated from urine and identified by tandem mass spectrometry as the taurine conjugate of IBP (IBP-Tau). The corresponding glycine con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3600ff9b7fd1f4148a847d11198c7bcd
https://pubmed.ncbi.nlm.nih.gov/8014860
https://pubmed.ncbi.nlm.nih.gov/8014860
Publikováno v:
SAR and QSAR in environmental research. 2(1-2)
The relative occurrence of N−demethylation and N−oxidation in a structurally diverse set of N−methyl tertiary amines was examined using structure-reactivity maps. A structure-reactivity map of the data indicated important structural features us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fade34a923263a77b683542bb72b63
https://pubmed.ncbi.nlm.nih.gov/8790642
https://pubmed.ncbi.nlm.nih.gov/8790642
Autor:
S C, Laizure, L K, Franklin, D G, Kaiser, C L, Williams, R C, Stevens, P L, Sanders, M, Miller
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(5)
Tirilazad mesylate (Freedox, Upjohn) is the first agent of a new class of compounds called lazaroids currently under clinical investigation for its potential beneficial effects following neurotrauma. Tirilazad's therapeutic effect is due to its abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12b715b5ccbdddf33c01ea4f5d297704
https://pubmed.ncbi.nlm.nih.gov/7902261
https://pubmed.ncbi.nlm.nih.gov/7902261
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(2)
Deuterium labeling techniques and stereoselective GC/MS methodology have been employed to investigate the mechanism by which R-ibuprofen undergoes metabolic chiral inversion in the rat in vivo. Following oral administration of a mixture of R-ibuprofe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bae110f1dec1abf679938782ad18efe4
https://pubmed.ncbi.nlm.nih.gov/1676645
https://pubmed.ncbi.nlm.nih.gov/1676645
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(4)
The oxidative metabolism and chiral inversion of ibuprofen in freshly isolated rat hepatocytes was studied with the aid of a stereoselective GC/MS assay procedure. Hydroxylation of the isobutyl side chain at the subterminal carbon (to give hydroxyibu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::663b8ca2c352135fbf32a1e8c732dcc4
https://pubmed.ncbi.nlm.nih.gov/1976078
https://pubmed.ncbi.nlm.nih.gov/1976078
Publikováno v:
Journal of Applied Physiology. 44:939-944
The time course of ventilatory adaptation to medroxyprogesterone acetate (MPA) and potential mediators of this response in plasma and lumbar CSF were determined in five healthy adult males. A significant decrease in arterial PCO2 (PACO2) at rest and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b73cd643acd1948063a68e8b7e79ff
https://doi.org/10.1152/jappl.1978.44.6.939
https://doi.org/10.1152/jappl.1978.44.6.939
Publikováno v:
Analytical Chemistry. 59:1504-1509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd7baa376bf6bbf2e5ff3a38e86c07a
https://doi.org/10.1021/ac00138a006
https://doi.org/10.1021/ac00138a006
Autor:
D. G. Kaiser
Publikováno v:
Analytical Chemistry. 35:552-554
A quantitative radioisotopic method for distinguishing and determining neomycins B, C, and neamine (neomycin A) is presented. The procedure is based on the paper chromatographic separation of the carbon-14 N-acetyl derivatives in a system composed of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92c699239809fbd7a4cf4291300969d
https://doi.org/10.1021/ac60197a004
https://doi.org/10.1021/ac60197a004
Autor:
D G, Kaiser, E M, Glenn
Publikováno v:
Research communications in chemical pathology and pharmacology. 8(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f369eb8d930629ace0c51f4b4df7c547
https://pubmed.ncbi.nlm.nih.gov/4423822
https://pubmed.ncbi.nlm.nih.gov/4423822