Zobrazeno 1 - 10
of 27
pro vyhledávání: '"D. G. COVELL"'
Publikováno v:
The Journal of Immunology. 158:3651-3658
In an effort to better understand functional recognition of structurally dissimilar ligands by a single TCR, a model system for studying cross-recognition of disparate peptide/class I complexes was developed using the murine (H-2b) CTL clone AHIII12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f7020c283b3f158a676885eee45c4b
https://doi.org/10.4049/jimmunol.158.8.3651
https://doi.org/10.4049/jimmunol.158.8.3651
Publikováno v:
Journal of computer-aided molecular design. 15(1)
Protein C (PC), a 62 kDa multi-modular zymogen, is activated to an anticoagulant serine protease (activated PC or APC) by thrombin bound to thrombomodulin on the surface of endothelial cells. PC/APC interacts with many proteins and the characterisati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0964b13a3398d21751520a765349527d
https://pubmed.ncbi.nlm.nih.gov/11219426
https://pubmed.ncbi.nlm.nih.gov/11219426
Publikováno v:
The Journal of biological chemistry. 275(51)
2-Chloroacetyl-2-demethylthiocolchicine (2CTC) and 3-chloroacetyl-3-demethylthiocolchicine (3CTC) resemble colchicine in binding to tubulin and react covalently with beta-tubulin, forming adducts with cysteine residues 239 and 354. The adducts at Cys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ccf9138b359cc2f4315f3c1d5c238e6
https://pubmed.ncbi.nlm.nih.gov/11005811
https://pubmed.ncbi.nlm.nih.gov/11005811
Autor:
O, Keskin, I, Bahar, R L, Jernigan, J A, Beutler, R H, Shoemaker, E A, Sausville, D G, Covell
Publikováno v:
Anti-cancer drug design. 15(2)
An analysis of the growth inhibitory potency of 122 anticancer agents available from the National Cancer Institute anticancer drug screen is presented. Methods of singular value decomposition (SVD) were applied to determine the matrix of distances be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f733f6cd79343ee940867412bc1de069
https://pubmed.ncbi.nlm.nih.gov/10901296
https://pubmed.ncbi.nlm.nih.gov/10901296
Autor:
Carole A. Bewley, D G Covell, Angela M. Gronenborn, G M Clore, Ad Bax, Michael R. Boyd, Kirk R. Gustafson
Publikováno v:
Nature structural biology. 5(7)
The solution structure of cyanovirin-N, a potent 11,000 Mr HIV-inactivating protein that binds with high affinity and specificity to the HIV surface envelope protein gp120, has been solved by nuclear magnetic resonance spectroscopy, including extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d506ad9e4df21d39af237ebe26d476
https://pubmed.ncbi.nlm.nih.gov/9665171
https://pubmed.ncbi.nlm.nih.gov/9665171
Autor:
A, Wallqvist, D G, Covell
Publikováno v:
Proteins. 25(4)
We present a docking scheme that utilizes both a surface complementarity screen as well as an energetic criterion based on surface area burial. Twenty rigid enzyme/inhibitor complexes with known coordinate sets are arbitrarily separated and reassembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::162e7ac1aef4f40a1f95571fdbe31760
https://pubmed.ncbi.nlm.nih.gov/8865336
https://pubmed.ncbi.nlm.nih.gov/8865336
The chemokine family of chemotactic cytokines plays a key role in orchestrating the immune response. The family has been divided into 2 subfamilies, alpha and beta, based on the spacing of the first 2 cysteine residues, function, and chromosomal loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177d1c16f521b2c3753de364c9d74d43
https://europepmc.org/articles/PMC2142647/
https://europepmc.org/articles/PMC2142647/
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 31(7)
For successful use of radiolabeled monoclonal antibodies (MAbs) for diagnosis and therapy, it is helpful to understand both global and microscopic aspects of antibody biodistribution. In this study, antibody distribution in a tumor is simulated by sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac754c99ed7885354e5c078eab65800f
https://pubmed.ncbi.nlm.nih.gov/2362198
https://pubmed.ncbi.nlm.nih.gov/2362198
Autor:
O D Holton, C D Black, R J Parker, D G Covell, J Barbet, S M Sieber, M J Talley, J N Weinstein
Publikováno v:
The Journal of Immunology. 139:3041-3049
Quantitative pharmacokinetic measurements of uptake and metabolism for two murine immunoglobulin G1 (IgG1) monoclonal antibodies (anti-Lyb8.2, MOPC-21) and their F(ab')2 and Fab' fragments were obtained following i.v. administration into C57BL/6 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5733e7c8e8d6d42f0843286e368cfa18
https://doi.org/10.4049/jimmunol.139.9.3041
https://doi.org/10.4049/jimmunol.139.9.3041
Publikováno v:
Academic Medicine. 54:461-6
Community hospitals and medical schools have different but complementary resources to carry out continuing medical education. To strengthen the educational capabilities of both, a group of community hospitals has been linked to a medical school in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce0d929971e676024294ac85407a54a9
https://doi.org/10.1097/00001888-197906000-00003
https://doi.org/10.1097/00001888-197906000-00003