Zobrazeno 1 - 10
of 1 016
pro vyhledávání: '"D. Funk"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm. Mechanism
Externí odkaz:
https://doaj.org/article/c73d03ece89c41cd9911432514397d9f
Autor:
Hartwig Anzt, Felix Bach, Stephan Druskat, Frank Löffler, Axel Loewe, Bernhard Y. Renard, Gunnar Seemann, Alexander Struck, Elke Achhammer, Piush Aggarwal, Franziska Appel, Michael Bader, Lutz Brusch, Christian Busse, Gerasimos Chourdakis, Piotr Wojciech Dabrowski, Peter Ebert, Bernd Flemisch, Sven Friedl, Bernadette Fritzsch, Maximilian D. Funk, Volker Gast, Florian Goth, Jean-Noël Grad, Jan Hegewald, Sibylle Hermann, Florian Hohmann, Stephan Janosch, Dominik Kutra, Jan Linxweiler, Thilo Muth, Wolfgang Peters-Kottig, Fabian Rack, Fabian H.C. Raters, Stephan Rave, Guido Reina, Malte Reißig, Timo Ropinski, Joerg Schaarschmidt, Heidi Seibold, Jan P. Thiele, Benjamin Uekermann, Stefan Unger, Rudolf Weeber
Publikováno v:
F1000Research, Vol 9 (2021)
Research software has become a central asset in academic research. It optimizes existing and enables new research methods, implements and embeds research knowledge, and constitutes an essential research product in itself. Research software must be su
Externí odkaz:
https://doaj.org/article/c322fd9ea10e47ff91236374789d1f72
Autor:
Colin D. Funk, Ali Ardakani
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) has wreaked havoc during the global pandemic of 2020 infecting millions and leaving over a half million dead. As a new virus, not previously in the human population, but with similarities to othe
Externí odkaz:
https://doaj.org/article/87e4047baf3140c1bfd2ee01aab7b4d9
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
A novel coronavirus SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) has entered the human population and has spread rapidly around the world in the first half of 2020 causing a global pandemic. The virus uses its spike glycoprotein receptor-bi
Externí odkaz:
https://doaj.org/article/e331ed48f34e4c7b8b740a04dd50bf20
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 122-130 (2018)
Progress in gene editing research has been accelerated by utilizing engineered nucleases in combination with induced pluripotent stem cell (iPSC) technology. Here, we report transcription activator-like effector nuclease (TALEN)-mediated reincorporat
Externí odkaz:
https://doaj.org/article/5c25580fe484488fb2b78edcd83ed99d
Autor:
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 1, Pp 89-101 (2018)
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids. To address the functional interchangeability of th
Externí odkaz:
https://doaj.org/article/4450a3c1881d499a884a360424200b75
Autor:
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 1, Pp 102-112 (2018)
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We used three engineered mo
Externí odkaz:
https://doaj.org/article/8f52a30ace1d45f2ac18c73e847ab6e1
A guide for assessing an organization's data quality practice and a roadmap for implementing a viable data and information quality management program, based on rigorous research and drawing on real-world examples.All organizations today confront data
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginas
Externí odkaz:
https://doaj.org/article/eae6a3ed458b46789cceae268bf9e7a9
Autor:
Robert J. Reklow, Tucaaue S. Alvares, Yong Zhang, Ana P. Miranda Tapia, Vivian Biancardi, Alexis K. Katzell, Sara M. Frangos, Megan A. Hansen, Alexander W. Toohey, Carol E. Cass, James D. Young, Silvia Pagliardini, Detlev Boison, Gregory D. Funk
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary de
Externí odkaz:
https://doaj.org/article/e433dca14c03434abf16ad50ac268923