Zobrazeno 1 - 10
of 145
pro vyhledávání: '"D. Flower"'
Autor:
Marc Ciosi, Alastair Maxwell, Sarah A. Cumming, Davina J. Hensman Moss, Asma M. Alshammari, Michael D. Flower, Alexandra Durr, Blair R. Leavitt, Raymund A.C. Roos, Peter Holmans, Lesley Jones, Douglas R. Langbehn, Seung Kwak, Sarah J. Tabrizi, Darren G. Monckton
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 568-580 (2019)
Background: Huntington disease (HD) is caused by an unstable CAG/CAA repeat expansion encoding a toxic polyglutamine tract. Here, we tested the hypotheses that HD outcomes are impacted by somatic expansion of, and polymorphisms within, the HTT CAG/CA
Externí odkaz:
https://doaj.org/article/e8c098c00c394408a8d5c2c5d49ab489
Autor:
Sarah J Tabrizi, Carlos Estevez-Fraga, Willeke M C van Roon-Mom, Michael D Flower, Rachael I Scahill, Edward J Wild, Ignacio Muñoz-Sanjuan, Cristina Sampaio, Anne E Rosser, Blair R Leavitt
Publikováno v:
Lancet Neurol
Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder; however, no disease-modifying interventions are available for patients with this disease. The molecular pathogenesis of Huntington's disease is complex, with tox
Publikováno v:
Current opinion in neurology. 33(4)
Huntington's disease is a fatal autosomal dominant neurodegenerative disorder caused by a trinucleotide expansion in the HTT gene, and current therapies focus on symptomatic treatment. This review explores therapeutic approaches that directly target
Publikováno v:
Nature reviews. Neurology. 16(10)
Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms. Mutant HTT (mHTT) disrupts transcription, interferes with immune and mitochondrial
Akademický článek
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Publikováno v:
International Laser Safety Conference.
A probabilistic laser hazard assessment for air-to-ground laser-target designator operations involves the use of probabilistic functions to estimate the risk of an unprotected observer being inadvertently irradiated by errant laser energy and sustain
Autor:
Neil Robertson, M. D. Flower
Publikováno v:
Journal of Neurology. 261:446-448
Occasionally our Journal Club is driven by the identification of a single clinical story or diagnosis encountered in routine clinical practice which sparks interest and identifies a need to develop knowledge of the disorder and a better understanding
Akademický článek
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Publikováno v:
International Laser Safety Conference.
The use of Probabilistic Risk Assessment (PRA) techniques to perform laser hazard analyses for lasers in outdoor environments has become an increasingly accepted alternative to standard deterministic methods, based on Maximum Permissible Exposure (MP
Publikováno v:
Seminars in Cell & Developmental Biology. 15:693-701