Výsledky vyhledávání - "D. F. Osborne"

Alanyl-glutamine prevents muscle atrophy and glutamine synthetase induction by glucocorticoids

Autor: I. E. Karl, D. F. Osborne, L. E. Wegrzyn, R. C. Hickson

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 271:R1165-R1172

The aims of this work were to establish whether glutamine infusion via alanyl-glutamine dipeptide provides effective therapy against muscle atrophy from glucorticoids and whether the glucocorticoid induction of glutamine synthetase (GS) is downregula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96409d3c6eae908b2c0cdc2b74551ca
https://doi.org/10.1152/ajpregu.1996.271.5.r1165

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Glutamine interferes with glucocorticoid-induced expression of glutamine synthetase in skeletal muscle

Autor: Robert C. Hickson, L. E. Wegrzyn, I. E. Karl, D. F. Osborne

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 270:E912-E917

Skeletal muscle atrophy from glucocorticoids is prevented by glutamine infusion. Because the gene-encoding glutamine synthetase (GS) is glucocorticoid inducible, it represented an appropriate model for resting whether glucocorticoids and glutamine ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635b347a5e1d7d76657109410ee7f5ac
https://doi.org/10.1152/ajpendo.1996.270.5.e912

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Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

Autor: R S, Hotchkiss, P E, Swanson, C M, Knudson, K C, Chang, J P, Cobb, D F, Osborne, K M, Zollner, T G, Buchman, S J, Korsmeyer, I E, Karl

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(7)

In sepsis there is extensive apoptosis of lymphocytes, which may be beneficial by down-regulating the accompanying inflammation. Alternatively, apoptosis may be detrimental by impairing host defense. We studied whether Bcl-2, a potent antiapoptotic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d303a33fcb7be01b1bc4e2f6ebeedf0
https://pubmed.ncbi.nlm.nih.gov/10201940

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Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis

Autor: S L, DeMeester, J P, Cobb, R S, Hotchkiss, D F, Osborne, I E, Karl, K W, Tinsley, T G, Buchman

Publikováno v: Surgery. 124(2)

Apoptosis, a mechanism of cell death prominent in critical illnesses including disseminated inflammation and multiorgan dysfunction syndrome, is characterized by morphologic changes including cell shrinkage, condensation of organelles, blebbing, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a51704c8ea76c14abd17581a8fe931bf
https://pubmed.ncbi.nlm.nih.gov/9706160

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Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 alpha in a mouse model of endotoxin

Autor: R S, Hotchkiss, D F, Osborne, G D, Lappas, I E, Karl

Publikováno v: Shock (Augusta, Ga.). 3(5)

Calcium plays an important role in the toxic effects of endotoxin, and calcium antagonists also have been shown to improve survival in animals challenged with endotoxin. Calcium may be involved in regulating cytokine production. Therefore, the protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5cb9798921e0088f67eac7689242384
https://pubmed.ncbi.nlm.nih.gov/7648334

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PROGRESSIVE REDUCTIONS IN BLOOD GLUTAMINE LEVELS AND IMPROVED PERFORMANCE OCCUR WITH COMPETITIVE SWIM TRAINING

Autor: I. E. Karl, Robert T. Chatterton, R. T. Groseth, J. M. Christie, D. F. Osborne, L. P. Koziris, Robert C. Hickson

Publikováno v: Medicine & Science in Sports & Exercise. 31:S86

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::851f3184c6825df7d08e4af52c171c3a
https://doi.org/10.1097/00005768-199905001-00278

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GLUTAMINE INTERFERES WITH GLUCOCORTICOID-INDUCED EXPRESSION Of GLUTAMINE SYNTHETASE IN SKELETAL MUSCLE 1100

Autor: L. E. Wegrzyn, Robert C. Hickson, I. E. Karl, D. F. Osborne

Publikováno v: Medicine & Science in Sports & Exercise. 28:185

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c83742f7adab311a5339ef8308ce532
https://doi.org/10.1097/00005768-199605001-01098

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Glucose metabolism in epitrochlearis muscle of acutely exercised and trained rats

Autor: T. L. Howard, D. F. Osborne, I. E. Karl, Saulo Klahr, Teresa A. Davis, E. D. Tegtmeyer

Publikováno v: The American journal of physiology. 250(2 Pt 1)

Effects of insulin on glycogen synthesis (GS), glycolytic utilization (GU), and glucose uptake (GT) were studied in isolated epitrochlearis muscles from exercise-trained or sedentary rats during recovery from acute exercise or at rest. During the 1st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51e049e124ad4e10b631d1a6994240
https://pubmed.ncbi.nlm.nih.gov/3953787

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Muscle protein turnover: effects of exercise training and renal insufficiency

Autor: E. D. Tegtmeyer, Saulo Klahr, D. F. Osborne, Herschel R. Harter, I. E. Karl, Teresa A. Davis

Publikováno v: The American journal of physiology. 248(3 Pt 1)

Chronic renal failure is associated with an enhanced catabolism of muscle protein. To determine the effect of exercise training and moderate renal insufficiency on net protein catabolism and protein synthesis in isolated epitrochlearis muscles, three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcf0431fe2f304b00c244c6f60eefc8
https://pubmed.ncbi.nlm.nih.gov/3883805

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