Zobrazeno 1 - 10
of 15
pro vyhledávání: '"D. F., Jarrard"'
Publikováno v:
The Prostate. 73(16)
Increasing age is a significant risk factor for prostate cancer. The prostate is exposed to environmental and endogenous stress that may underlie this remarkable incidence. DNA methylation, genomic imprinting, and histone modifications are examples o
Autor:
S P, Sterrett, D F, Jarrard
Publikováno v:
Minerva urologica e nefrologica = The Italian journal of urology and nephrology. 60(1)
Robotic assisted laparoscopic prostatectomy (RALP) is rapidly gaining acceptance in the urologic community as an effective treatment modality for the treatment of localized prostate cancer. For the open surgeon, this technology assists in the transit
Publikováno v:
The Journal of urology. 166(4)
Autor:
S, Sarkar, K P, Jülicher, M S, Burger, V, Della Valle, C J, Larsen, T R, Yeager, T B, Grossman, R W, Nickells, C, Protzel, D F, Jarrard, C A, Reznikoff
Publikováno v:
Cancer research. 60(14)
Inactivation of both the pRb (pRb-cyclin D1/cyclin-dependent kinase 4/6-p16) and p53 (p53-p21(WAF1)-p14(ARF)) pathways is thought to be essential for immortalization in vitro and malignant transformation in vivo. We identified different combinations
Autor:
H, Kinoshita, Y, Shi, C, Sandefur, L F, Meisner, C, Chang, A, Choon, C R, Reznikoff, G S, Bova, A, Friedl, D F, Jarrard
Publikováno v:
Cancer research. 60(13)
Advanced hormone-independent prostate cancer is characterized by a significant loss of androgen receptor (AR) expression in 20-30% of the tumors. The transcriptional block underlying this phenomenon is not known, but we have proposed that methylation
Publikováno v:
Journal of endourology. 14(3)
p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells
Autor:
D F, Jarrard, S, Sarkar, Y, Shi, T R, Yeager, G, Magrane, H, Kinoshita, N, Nassif, L, Meisner, M A, Newton, F M, Waldman, C A, Reznikoff
Publikováno v:
Cancer research. 59(12)
The cell cycle regulatory genes p16/CDKN2 and RB are frequently deleted in prostate cancers. In this study, we examined the role of alterations in p16 and pRb during growth, senescence, and immortalization in vitro of human prostate epithelial cells
Autor:
D F, Jarrard, H, Kinoshita, Y, Shi, C, Sandefur, D, Hoff, L F, Meisner, C, Chang, J G, Herman, W B, Isaacs, N, Nassif
Publikováno v:
Cancer research. 58(23)
Androgen-independent metastatic prostate cancer is characterized by a heterogeneous loss of androgen receptor (AR) expression among tumor cells. In this study, we evaluate DNA hypermethylation as a potential transcriptional regulatory mechanism in AR
Autor:
D F, Jarrard, R, Paul, A, van Bokhoven, S H, Nguyen, G S, Bova, M J, Wheelock, K R, Johnson, J, Schalken, M, Bussemakers, W B, Isaacs
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(11)
P-Cadherin is a member of the cadherin family of cell surface glycoproteins that mediate Ca2+-dependent cell-cell adhesion and is expressed in a differential fashion in normal epithelial tissues. The expression of P-cadherin in human prostate cancer
Autor:
J B, Nelson, W H, Lee, S H, Nguyen, D F, Jarrard, J D, Brooks, S R, Magnuson, T J, Opgenorth, W G, Nelson, G S, Bova
Publikováno v:
Cancer research. 57(1)
Production of the potent vasoconstrictor endothelin-1 (ET-1) by human prostate cancer cells accompanies prostate cancer progression in vivo. The predominant endothelin receptor expressed by normal prostate epithelium, ETB, is not expressed by any of