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Synthesis of fragments of the capsular polysaccharide of Haemophilus influenzae type b: Part I. Preparation of suitably protected 1-O-β-D-ribofuranosyl-D-ribitol building blocks

Autor: C. A. A. Van Boeckel, J. H. Van Boom, D. Evenberg, J. P. G. Hermans, L. Poot, P. Hoogerhout, M. Kloosterman, Jan Poolman, G. A. Van Der Marel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 106:498-504

The synthesis of the protected ribosylribitol derivatives 15 and 17, which are building blocks for the preparation of fragments of the H. influenzae type b polysaccharide, is presented. Starting from D-ribonolactone (1), 5-O-allyl-2,3,4-tri-O-benzyl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb61773133505f0c61885ba656ff0b30
https://doi.org/10.1002/recl.19871060905

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Preparation, Antigenicity, and Immunogenicity of Synthetic Ribosylribitol Phosphate Oligomer-Protein Conjugates and Their Potential Use for Vaccination against Haemophilus influenzae Type b Disease

Autor: C. A. A. Van Boeckel, D. Evenberg, Jan Poolman, Eduard Coen Beuvery, Ger T. Rijkers, J. H. Van Boom, P. Hoogerhout

Publikováno v: Journal of Infectious Diseases. 165:S152-S155

Synthetically prepared ribosylribitol phosphate dimer and trimer analogous to fragments of the capsular polysaccharide of Haemophilus influenzae type b, containing either an amino- or a (masked) thiol-functionalized spacer, were conjugated to protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff21935213a13e91967dbd4f5ec4a77
https://doi.org/10.1093/infdis/165-supplement_1-s152

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Synthetic trimer and tetramer of 3-beta-D-ribose-(1-1)-D-ribitol-5-phosphate conjugated to protein induce antibody responses to Haemophilus influenzae type b capsular polysaccharide in mice and monkeys

Autor: D. Evenberg, Helena Käyhty, L. Saarinen, C. A. A. Van Boeckel, J. H. Van Boom, P. Hoogerhout, C. C. A. M. Peeters, G. A. Van Der Marel, Jan Poolman

Publikováno v: Infection and immunity. 60(5)

Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage. Conjugates were made of trimeric and tetrameric ribose-ribitol-phosphate and tetan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1618555a77a5e1d89c4ba1da287e4b
https://pubmed.ncbi.nlm.nih.gov/1563770

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Vaccine-induced protective immunity against Aeromonas salmonicida tested in experimental carp erythrodermatitis

Autor: P. de Graaff, D. Evenberg, Ben J. J. Lugtenberg, W.B. van Muiswinkel

Publikováno v: Journal of Fish Diseases 11 (1988)
Journal of Fish Diseases, 11, 337-350

The development and applicability of a dose-controlled experimental infection with atypical Aeromonas salmonicida in carp is described. The proliferation and clinical manifestations of experimentally induced carp erythrodermatitis mimicked a natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae5f53100f693a5f35d52cf1eebf41c
https://doi.org/10.1111/j.1365-2761.1988.tb01229.x

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Synthesis of Fragments of the Capsular Polysaccharide of Haemophilus Influnzae Type B Part II. Preparation and Structural Analysis of Fragments Comprising two and Three Repeating Units

Autor: Jan-Remt Mellema, P. Hoogerhout, Gerard N. Wagenaars, D. Evenberg, C. A. A. Van Boeckel, Jan Poolman, G. A. Van Der Marel, A. W. M. Lefeber, J. H. Van Booma, Carel W. Funke

Publikováno v: Journal of Carbohydrate Chemistry. 7:399-416

The synthesis of spacer-containing fragments of the capsular poly-saccharide of H. influenzas, comprising two and three repeating units (9a and 9b, respectively), is presented. Ribosylribitol building blocks 1 and 2 were coupled with bis [1-benzotria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0a39bbc02783d0d89ca92068315d1ce
https://doi.org/10.1080/07328308808058933

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Synthesis of fragments of the capsular polysaccharide of haemophilus influenzae type B, comprising two or three repeating units

Autor: C. A. A. Van Boeckel, P. Hoogerhout, G. A. Van Der Marel, Eduard Coen Beuvery, D. Evenberg, Jan Poolman, J. H. Van Boom

Publikováno v: Tetrahedron Letters. 28:1553-1556

The synthesis of the ribosyl-ribitol derivatives 15 and 17 (Scheme 2) is presented. The compounds served as building blocks for the preparation of protected fragments ( 24 , n=1 or 2; Fig. 2) of the title polysaccharide. The bifunctional reagent bis[

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebdbbc80fab4b53fb447bf0700caa42a
https://doi.org/10.1016/s0040-4039(01)81040-6

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Cell surface of the fish pathogenic bacterium Aeromonas salmonicida. II. Purification and characterization of a major cell envelope protein related to autoagglutination, adhesion and virulence

Autor: D, Evenberg, B, Lugtenberg

Publikováno v: Biochimica et biophysica acta. 684(2)

The purification of the major protein of the membrane fraction of an autoagglutinating strain of Aeromonas salmonicida is described. This protein, designated as additional cell envelope protein, is water-insoluble, has a molecular weight of about 54

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::251166b63789869cbdd3365e6289d904
https://pubmed.ncbi.nlm.nih.gov/7055566

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Does Aeromonas salmonicida affect the immune system of carp, Cyprinus carpio L.?

Autor: C.N. Pourreau, D. Evenberg, W. M. de Raadt, J. A. N. van Mechelen, W.B. van Muiswinkel

Publikováno v: Veterinary immunology and immunopathology. 12(1-4)

Aeromonas salmonicida is a significant bacterial pathogen of cyprinid and salmonid fishes causing the systemic disease furunculosis. Several observations led us to believe that A. salmonicida was able to evade or suppress the immune system of the fis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a169424dbbe00567a5a89400a9dc3186
https://pubmed.ncbi.nlm.nih.gov/3765353

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Modulation of the mitogenic PHA response of carp, Cyprinus carpio L., by extracellular products of Aeromonas salmonicida

Autor: W.B. van Muiswinkel, M.B.H. Koopmans, C.N. Pourreau, G.F.R. Hendriks, D. Evenberg

Publikováno v: Journal of Fish Biology 31 (1987)
Journal of Fish Biology, 31, 133-143

The influence of bacteria-free supernatants from cultures of atypical virulent (V234/81, auto-agglutinating. A-layer positive) and avirulent (126/68, non-agglutinating, A-layer negative) strains of A. salmonicida, obtained after different culture tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42a4b0c76c25cc51e02efbc992a509f
https://research.wur.nl/en/publications/modulation-of-the-mitogenic-pha-response-of-carp-cyprinus-carpio-

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