Zobrazeno 1 - 10
of 91
pro vyhledávání: '"D. E. Rannels"'
Autor:
J. P. E. Spencer, G. K. Ostrander, D. E. Rannels, Danny R. Welch, E. T. Knobbe, William J. Meehan
Publikováno v:
Environmental and Molecular Mutagenesis. 33:273-278
Type II epithelial cells, which line the alveolar surface of the lung, are exposed to a variety of potentially mutagenic and carcinogenic insults. The purpose of this study was to determine if type II cells are susceptible to oxidative DNA damage in
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 272:L1105-L1114
Recent observations suggest that cell-cell interactions may modulate the response of the alveolar epithelium to injury. Expression and function of gap junctions were thus evaluated in isolated alveolar type II cells. Freshly isolated (day 0) type II
Autor:
J. W. Swisher, D. E. Rannels
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 272:L908-L915
Type II pulmonary epithelial cells (T2P) in primary culture assemble a biologically active extracellular matrix (ECM) from endogenously synthesized components, including fibronectin. Fibronectin is a well-recognized attachment protein that mediates c
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 272:L619-L630
Interactions of interstitial fibroblasts with nearby epithelial cells are thought to play a role in lung growth and development. The present studies support this premise. Medium conditioned by second-passage lung fibroblasts (FCM) stimulated both DNA
Autor:
D. E. Rannels, Yu-Chen Lee
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 270:L123-L132
The response of the alveolar epithelium to coal dust exposure is poorly understood. Coal or other dusts may act on the epithelium directly or indirectly through nearby alveolar macrophages (AM) that produce cytokines and other soluble products. AM an
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 269:L766-L775
Type II pulmonary epithelial cells in primary culture synthesize and assemble a multicomponent extracellular matrix which exhibits biological activity in vitro. Simultaneously, the pneumocytes degrade components of the underlying matrix, such that ma
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 268:L885-L893
Previous studies suggested an association between changes in extracellular matrix (ECM) and pulmonary epithelial cell growth and differentiation in lungs of adrenalectomized rats. The role of adrenal hormones to modulate synthesis of cell and ECM pro
Autor:
S. E. Dunsmore, D. E. Rannels
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 268:L336-L346
Rat type II pulmonary epithelial cells synthesize and assemble a multicomponent extracellular matrix (ECM) which can modulate cellular differentiation in primary culture. This study defines turnover of the type II cell matrix. Turnover kinetics were
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 5:351-362
The time course and nature of the cellular response to left pneumonectomy, with or without prior adrenalectomy, were evaluated in the right lungs of male Sprague-Dawley rats using morphometric techniques. Animals were studied at days 2, 5, and 14 fol
Publikováno v:
Chest. 99:18S-20