Výsledky vyhledávání - "D. E. Milenic"

Targeting strategies for cancer radiotherapy

Autor: D J, Buchsbaum, B E, Rogers, M B, Khazaeli, M S, Mayo, D E, Milenic, S V, Kashmiri, C J, Anderson, L L, Chappell, M W, Brechbiel, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5

Novel strategies to increase the therapeutic ratio in clinical radioimmunotherapy studies are needed. Limitations to radioimmunotherapy include bone marrow suppression due to the long circulating half-life of radiolabeled monoclonal antibodies (mAbs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27b351f7f8f74f5bed773a6b8347fe8e
https://pubmed.ncbi.nlm.nih.gov/10541342

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In vivo gene inoculation of a recombinant single-chain antitumor antibody induces anti-immunoglobulin response

Autor: G L, Prasad, H S, Lee, M, Iwahashi, D E, Milenic, S, Abrams, J, Schlom, S V, Kashmiri

Publikováno v: Cancer gene therapy. 4(4)

While in vivo gene inoculation is being increasingly exploited to express genes of choice and elicit specific immune responses in animal models, the utility of this method has not been explored extensively for the expression of antibody genes. The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a13090cd85643f26832b269531eb0b65
https://pubmed.ncbi.nlm.nih.gov/9253511

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Biological properties of chimeric domain-deleted anticarcinoma immunoglobulins

Autor: D C, Slavin-Chiorini, S V, Kashmiri, J, Schlom, B, Calvo, L M, Shu, M E, Schott, D E, Milenic, P, Snoy, J, Carrasquillo, K, Anderson

Publikováno v: Cancer research. 55

CC49 is a second-generation monoclonal antibody (MAb) that has high affinity for the tumor-associated pancarcinoma antigen tumor-associated glycoprotein-72. In clinical trials using gamma scanning, radiolabeled CC49 has facilitated the detection of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::927c7fa0c70845ab265f2445763ba5b4
https://pubmed.ncbi.nlm.nih.gov/7493377

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Phase I study of intravenous Lu-labeled CC49 murine monoclonal antibody in patients with advanced adenocarcinoma

Autor: T, Mulligan, J A, Carrasquillo, Y, Chung, D E, Milenic, J, Schlom, I, Feuerstein, C, Paik, P, Perentesis, J, Reynolds, G, Curt

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 1(12)

CC49, a murine monoclonal antibody that recognizes the tumor-associated glycoprotein 72, was conjugated to the chemical chelate 1,4,7,10-tetraaza-1-(1-carboxy-3-(4-aminophenyl) propyl)-tris-4,7,10- ((carboxy)methyl)cyclododecane that had been labeled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f4654ba67a5d68e59bf901d05ba24d5
https://pubmed.ncbi.nlm.nih.gov/9815943

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Improved tumor radioimmunodetection using a single-chain Fv and gamma-interferon: potential clinical applications for radioimmunoguided surgery and gamma scanning

Autor: C A, Nieroda, D E, Milenic, J A, Carrasquillo, J, Scholm, J W, Greiner

Publikováno v: Cancer research. 55(13)

Previous studies have shown that (a) single-chain antibody binding proteins, or sFvs, localize experimental tumor xenografts (D.E. Milenic et al, Cancer Res., 51: 6363-6371, 1991) and (b) the administration of gamma-interferon (IFN-gamma) increases t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41bbd997dffd75c025977162014c960c
https://pubmed.ncbi.nlm.nih.gov/7796413

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Autoradiographic evaluation of radiolabeled monoclonal antibody B72.3 distribution in tumor and lymph nodes of adenocarcinoma patients

Autor: M, Roselli, C L, Hitchcock, A, Molinolo, D E, Milenic, D, Colcher, E W, Martin, G H, Hinkle, J, Schlom

Publikováno v: Anticancer research. 15(3)

Monoclonal antibody B72.3 recognizes a pancarcinoma antigen termed TAG-72 and is the MAb in "OncoScint CR/OV". Patients undergoing surgical resection of primary or metastatic colorectal or breast carcinoma or pseudomyxoma peritonei were injected i.v.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e714225756badc377c2f62005a16346
https://pubmed.ncbi.nlm.nih.gov/7645989

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Biodistribution and preclinical radioimmunotherapy studies using radiolanthanide-labeled immunoconjugates

Autor: M E, Schott, J, Schlom, K, Siler, D E, Milenic, D, Eggensperger, D, Colcher, R, Cheng, W J, Kruper, W, Fordyce, W, Goeckeler

Publikováno v: Cancer. 73

Lutetium-177 (177Lu), samarium-153 (153Sm), and yttrium-90 (90Y) are members of the family of elements known as lanthanides or rare earths. Monoclonal antibody CC49, a murine immunoglobulin (Ig) G1, which is reactive with the tumor-associated antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2399fa05fc7d943a33fa29c54074f10
https://pubmed.ncbi.nlm.nih.gov/8306291

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Microautoradiographic analysis of the normal organ distribution of radioiodinated single-chain Fv and other immunoglobulin forms

Autor: T, Yokota, D E, Milenic, M, Whitlow, J F, Wood, S L, Hubert, J, Schlom

Publikováno v: Cancer research. 53(16)

In previous studies, we have compared the immunochemical properties, the in vivo pharmacokinetics, and the tumor penetrance of a radioiodinated single-chain Fv (sFv) in comparison with other immunoglobulin (Ig) forms (intact IgG, F(ab')2, and Fab') (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9df03972a173d8971f6b4d888db5c051
https://pubmed.ncbi.nlm.nih.gov/8339291

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