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Akademický článek

A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C

Autor: D J Hanahan, S T Weintraub, S J Friedberg, A Tokumura, D E Ayer

Publikováno v: Journal of Lipid Research, Vol 26, Iss 11, Pp 1345-1355 (1985)

A novel reaction was explored in which synthetic platelet-activating factor, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC), upon treatment with 1 N NaOH in methanol at 60 degrees C for 20 min, sequentially released the acetyl group, then the

Externí odkaz: https://doaj.org/article/7241b18d39b34b41a4b86dffd20733af

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The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism

Autor: A N, Billin, D E, Ayer

Publikováno v: Current topics in microbiology and immunology. 302

Recent experiments suggest the existence of a transcriptional network that functions in parallel to the canonical Myc/Max/Mad transcriptional network. Unlike the Myc/Max/Mad network, our understanding of this network is still in its infancy. At the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7043223fb9794edc75531b064a08eff1
https://pubmed.ncbi.nlm.nih.gov/16620032

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Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex

Autor: K, Brubaker, S M, Cowley, K, Huang, L, Loo, G S, Yochum, D E, Ayer, R N, Eisenman, I, Radhakrishnan

Publikováno v: Cell. 103(4)

Gene-specific targeting of the Sin3 corepressor complex by DNA-bound repressors is an important mechanism of gene silencing in eukaryotes. The Sin3 corepressor specifically associates with a diverse group of transcriptional repressors, including memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b57c4d53ea980f966133c0d074616cf5
https://pubmed.ncbi.nlm.nih.gov/11106735

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Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants

Autor: E D, Hall, P K, Andrus, S L, Smith, J A, Oostveen, H M, Scherch, B S, Lutzke, T J, Raub, G A, Sawada, J R, Palmer, L S, Banitt, J S, Tustin, K L, Belonga, D E, Ayer, G L, Bundy

Publikováno v: Acta neurochirurgica. Supplement. 66

The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef2a22bfa5202feee4c71d54b7000ffa
https://pubmed.ncbi.nlm.nih.gov/8780807

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Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions

Autor: P J, Koskinen, D E, Ayer, R N, Eisenman

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(6)

Mad is a bHLH/Zip protein that, as a heterodimer with Max, can repress Myc-induced transcriptional transactivation. Expression of Mad is induced upon terminal differentiation of several cell types, where it has been postulated to down-regulate Myc-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a887e44a66bd62b0234b1fc6826cc0cf
https://pubmed.ncbi.nlm.nih.gov/7669717

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Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19

Autor: S, Edelhoff, D E, Ayer, A S, Zervos, E, Steingrímsson, N A, Jenkins, N G, Copeland, R N, Eisenman, R, Brent, C M, Disteche

Publikováno v: Oncogene. 9(2)

Both the MAD and the MXI1 genes encode basic-helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors which bind Max in vitro, forming a sequence-specific DNA-binding complex similar to the Myc-Max heterodimer. Mad and Myc compete for binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::993bdeb75c81c0bf8f14068973c9da5a
https://pubmed.ncbi.nlm.nih.gov/8290278

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Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma

Autor: E J, Jacobsen, J M, McCall, D E, Ayer, F J, Van Doornik, J R, Palmer, K L, Belonga, J M, Braughler, E D, Hall, D J, Houser, M A, Krook

Publikováno v: Journal of medicinal chemistry. 33(4)

A novel class of 21-aminosteroids has been developed. Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain homogenates with IC50's as low as 3 microM. Furthermore, selected members enhance early neurolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e58ba70111a269922c928458ad3f70f
https://pubmed.ncbi.nlm.nih.gov/2319560

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Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors

Autor: W B, Im, D P, Blakeman, J P, Davis, D E, Ayer

Publikováno v: Molecular pharmacology. 37(3)

Functional interactions between steroidal anesthetics and gamma-aminobutyric acidA (GABAA) receptors have been examined with 36Cl- uptake measurements in rat cerebrocortical synaptoneurosomes. The primary effect of the steroids was to enhance the aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b10f8efeb9426b0e17a394932445157e
https://pubmed.ncbi.nlm.nih.gov/2156155

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