Výsledky vyhledávání - "D. Dianne Hodges"

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties

Autor: Elfrida R. Grant, Mohamed Hachicha, Edward R. Whittemore, Lori Schmid, D. Dianne Hodges, Shiazah Malik, Kenneth J. Valenzano, Joseph Francis, James T. Limberis, Laykea Tafesse, Yakov Rotshteyn, Gang Wu, Qun Sun

Publikováno v: The Journal of pharmacology and experimental therapeutics. 306(1)

Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors. Although blockade of capsaicin-induced VR1 ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd8650181ee21ad52408c152415e829
https://pubmed.ncbi.nlm.nih.gov/12721338

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