Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate

Autor: Xuanrong Chen, Michael A. Augello, Deli Liu, Kevin Lin, Alex Hakansson, Martin Sjöström, Francesca Khani, Lesa D. Deonarine, Yang Liu, Jaida Travascio-Green, Jiansheng Wu, Un In Chan, Jude Owiredu, Massimo Loda, Felix Y. Feng, Brian D. Robinson, Elai Davicioni, Andrea Sboner, Christopher E. Barbieri

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription

Externí odkaz: https://doaj.org/article/07a68e6011a946bc9d120ecc4b67fc67

The role of photovaporization of the prostate in small volume benign prostatic hyperplasia and review of the literature

Autor: Alexis E. Te, Malek Meskawi, Kevin C. Zorn, Lesa D. Deonarine, Vincent Misrai, Bilal Chughtai, Ramy Goueli, Dominique Thomas, Pierre-Alain Hueber

Publikováno v: Asian Journal of Urology, Vol 6, Iss 4, Pp 353-358 (2019)
Asian Journal of Urology

Objective: Our objective was to characterize the safety and efficacy of the 180 W XPS-GreenLight laser in men with lower urinary tract symptoms secondary to a small volume benign prostatic hyperplasia (BPH). Methods: A retrospective analysis was perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8b8485783b178a4166954619535659
https://doi.org/10.1016/j.ajur.2019.01.006

G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

Autor: Chandrani Mukhopadhyay, Lesa D. Deonarine, Dennis Huang, Arul M. Chinnaiyan, Deli Liu, Yu Wang, Brian D. Robinson, Christopher E. Barbieri, Joanna Cyrta, Pengbo Zhou, Elai Davicioni, Chenyi Yang, Mark A. Rubin, Limei Xu, Andrea Sboner

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mukhopadhyay, Chandrani; Yang, Chenyi; Xu, Limei; Liu, Deli; Wang, Yu; Huang, Dennis; Deonarine, Lesa Dayal; Cyrta, Joanna; Davicioni, Elai; Sboner, Andrea; Robinson, Brian D; Chinnaiyan, Arul M; Rubin, Mark A; Barbieri, Christopher E; Zhou, Pengbo (2021). G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer. Nature Communications, 12(1), p. 6662. Springer Nature 10.1038/s41467-021-27024-x

SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 as an interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafb7b6620fd672c80f1eca55319f78b

SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG

Autor: Andrea Sboner, Lesa D. Deonarine, Mirjam Blattner, Deli Liu, Brian D. Robinson, Kyung Park, Jonathan Shoag, Christopher E. Barbieri, Yu Chen, Juan Miguel Mosquera, Mark A. Rubin

Publikováno v: The Journal of Clinical Investigation
Shoag, Jonathan; Liu, Deli; Blattner, Mirjam; Sboner, Andrea; Park, Kyung; Deonarine, Lesa; Robinson, Brian D; Mosquera, Juan Miguel; Chen, Yu; Rubin, Mark Andrew; Barbieri, Christopher E (2018). SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG. Journal of clinical investigation, 128(1), pp. 381-386. American Society for Clinical Investigation 10.1172/JCI96551

Nearly 50% of prostate cancers harbor gene fusions that lead to overexpression of the transcription factor ERG, while a mutually exclusive 10% of prostate cancers harbor recurrent mutations in the gene encoding the E3 ubiquitin ligase SPOP. Recent re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6c00ea40653805efbcd5a79a72e60d
https://doi.org/10.1172/jci96551

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis

Autor: Deli Liu, Ashley S. Doane, Olivier Elemento, Andrea Sboner, Lesa D. Deonarine, Andries M. Bergman, Elissa W.P. Wong, Noah Dephoure, Mark A. Rubin, Michael A. Augello, Dennis Huang, Mirjam Blattner, Himisha Beltran, Brian D. Robinson, Suzan Stelloo, Christopher E. Barbieri, Wilbert Zwart, Yu Chen

Publikováno v: Cancer Cell, 35(4), 603-617.e8. Cell Press

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and reasons for its tissue-specific loss remain undefined. We demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03e71ea8583cd3049584b23988b251a