Zobrazeno 1 - 10
of 124
pro vyhledávání: '"D. Deegan"'
Publikováno v:
eLife, Vol 9 (2020)
The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Unti
Externí odkaz:
https://doaj.org/article/6c8161f617dc48f6bb5652e3e06dc23f
Publikováno v:
Neural Computing and Applications. 34:6879-6905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb94aa412de664b87f5fbd2671228bf3
https://doi.org/10.1007/s00521-021-06788-9
https://doi.org/10.1007/s00521-021-06788-9
Autor:
Tom D Deegan, Karim Labib, Giuseppe Cannone, Michael Jenkyn-Bedford, Joseph T.P. Yeeles, Yasemin Baris, Morgan L. Jones
Publikováno v:
Nature
Jenkyn-Bedford, M, Jones, M L, Baris, Y, Labib, K P M, Cannone, G, Yeeles, J T P & Deegan, T D 2021, ' A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes ', Nature . https://doi.org/10.1038/s41586-021-04145-3
Jenkyn-Bedford, M, Jones, M L, Baris, Y, Labib, K P M, Cannone, G, Yeeles, J T P & Deegan, T D 2021, ' A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes ', Nature . https://doi.org/10.1038/s41586-021-04145-3
Replisome disassembly is the final step of eukaryotic DNA replication and is triggered by ubiquitylation of the CDC45–MCM–GINS (CMG) replicative helicase1–3. Despite being driven by evolutionarily diverse E3 ubiquitin ligases in different eukar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3762dde9c47e717fe2f32dd809798c47
https://doi.org/10.1038/s41586-021-04145-3
https://doi.org/10.1038/s41586-021-04145-3
Autor:
Berta Canal, Tom D Deegan, Karim Labib, Agustina P Bertolin, Rupert Beale, John F.X. Diffley, Florian Weissmann, Michael Howell, Ryo Fujisawa, Mary Wu, Lucy S. Drury, Rachel Ulferts, Allison W McClure, Jingkun Zeng
Publikováno v:
Biochemical Journal
SummarySARS-CoV-2 is responsible for COVID-19, a human disease that has caused over 2 million deaths, stretched health systems to near-breaking point and endangered the economies of countries and families around the world. Antiviral treatments to com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3c0762d3a6f4930c63db5b106f20b7
http://europepmc.org/articles/PMC8286823
http://europepmc.org/articles/PMC8286823
Autor:
Kang Wei Tan, Emma L. Roberts, Tiffany Mak, Lucy S. Drury, Souradeep Basu, Berta Canal, Michael Howell, Joseph F. Curran, Florian Weissmann, Karim Labib, Tom D Deegan, John F.X. Diffley, Allison W McClure, Ryo Fujisawa, Mary Wu, Victoria H. Cowling, Rachel Ulferts, Clovis Basier, Rupert Beale, Theresa U. Zeisner, Chew Theng Lim
Publikováno v:
Biochemical Journal
The COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause a fatal disease in humans. There is currently only one antivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74acc162b19fe84f371a9c793c9d9297
http://europepmc.org/articles/PMC8286817
http://europepmc.org/articles/PMC8286817
Autor:
Cristian Polo Rivera, Tom D. Deegan
Publikováno v:
Polo Rivera, C & Deegan, T D 2022, ' Replicon-seq : seeing is believing ', Trends in Genetics, vol. 38, no. 10, pp. 987-988 . https://doi.org/10.1016/j.tig.2022.05.012
Mol Cell
Mol Cell
Fundamental aspects of DNA replication, such as the anatomy of replication stall sites, how replisomes are influenced by gene transcription and whether the progression of sister replisomes is coordinated are poorly understood. Available techniques do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a36c101acf929f612181989d5a7ac5a
https://doi.org/10.1016/j.tig.2022.05.012
https://doi.org/10.1016/j.tig.2022.05.012
Publikováno v:
The EMBO Journal
The eukaryotic replisome is rapidly disassembled during DNA replication termination. In metazoa, the cullin‐RING ubiquitin ligase CUL‐2LRR‐1 drives ubiquitylation of the CMG helicase, leading to replisome disassembly by the p97/CDC‐48 “unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9119b29ea961c229495c12108e47927
https://pubmed.ncbi.nlm.nih.gov/34269473
https://pubmed.ncbi.nlm.nih.gov/34269473
Autor:
Rachel Ulferts, Souradeep Basu, John F.X. Diffley, Tom D Deegan, Joseph F. Curran, Lucy S. Drury, Chew Theng Lim, Tiffany Mak, Ryo Fujisawa, Clovis Basier, Mary Wu, Karim Labib, Theresa U. Zeisner, Kang Wei Tan, Florian Weissmann, Victoria H. Cowling, Michael Howell, Rupert Beale, Allison W McClure, Emma A. Roberts, Berta Canal
SummaryThe COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause fatal disease in humans. There is currently only one an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f9af0849d5ef9495919122a84bdc9c1
https://doi.org/10.1101/2021.04.07.438810
https://doi.org/10.1101/2021.04.07.438810
Autor:
Mary Wu, Clovis Basier, George Papageorgiou, Michael Howell, Christelle Soudy, Theresa U. Zeisner, Rachel Ulferts, John F.X. Diffley, Chew Theng Lim, Dhira Joshi, Joseph F. Curran, Florian Weissmann, Hema Nagaraj, Tom D Deegan, Ryo Fujisawa, Berta Canal, Karim Labib, Kang Wei Tan, Ganka Bineva-Todd, Jennifer C. Milligan, Rupert Beale
The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented health and socio-economic effects for the global population. While different vaccines are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9335764f2cf6ed64e157d65e251c782
https://doi.org/10.1101/2021.04.07.438804
https://doi.org/10.1101/2021.04.07.438804
Autor:
Florian Weissmann, Chew Theng Lim, Clovis Basier, Christelle Soudy, Nicola O’Reilly, Karim Labib, Tom D Deegan, Ganka Bineva-Todd, Theresa U. Zeisner, Kang Wei Tan, Berta Canal, Rachel Ulferts, John F.X. Diffley, Dhira Joshi, Rupert Beale, Jennifer C. Milligan, Joseph F. Curran, George Papageorgiou, Michael Howell, Mary Wu, Ryo Fujisawa, Hema Nagaraj
Publikováno v:
Biochemical Journal
SummaryThe coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented health and socio-economic effects for the global population. While different vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d3622d6627d0c0a5a33acb1408e403
https://doi.org/10.1101/2021.04.07.438806
https://doi.org/10.1101/2021.04.07.438806