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Novel use of riociguat in infants with severe pulmonary arterial hypertension unable to wean from inhaled nitric oxide

Autor: L. T. Domingo, D. D. Ivy, S. H. Abman, A. M. Grenolds, J. T. MacLean, J. A. Breaux, K. J. Minford, B. S. Frank

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

IntroductionRiociguat, an oral soluble guanylate cyclase stimulator, has been approved for use in adults with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension. However, there is limited data on its therapeutic u

Externí odkaz: https://doaj.org/article/11bfa1b253744b86ba5fef737de2dfac

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Abstract 11636: Right Ventricle Lymphatic Vessel Insufficiency Contributes to Interstitial Fluid Stasis, Inflammation, Fibrosis, and Failure in Pulmonary Hypertension

Autor: Kelley L Colvin, Ozus Lohani, Sarah M Williams, D D Ivy, Kurt R Stenmark, Michael E Yeager

Publikováno v: Circulation. 130

Introduction: Pulmonary hypertension (PH) is characterized by cardiopulmonary remodeling. The ensuing right ventricular (RV) hypertrophy and failure contribute to significant mortality. Pericardial effusion worsens the prognosis for PH patients, yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7df1742488e036fee21c4c1fa606535e
https://doi.org/10.1161/circ.130.suppl_2.11636

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Comparison of strength properties of normotensive and hypertensive rat pulmonary arteries

Autor: E S, Drexler, C N, McCowan, J E, Wright, A J, Slifka, D D, Ivy, R, Shandas

Publikováno v: Biomedical sciences instrumentation. 40

A series of tests were conducted to quantify the difference in the mechanical properties of normo- and hypertensive pulmonary arteries. A bubble-test design was employed to measure the biaxial properties of a segment of artery. The test results compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2701fa73c04942d4afe9e573945ef2cc
https://pubmed.ncbi.nlm.nih.gov/15133974

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Congenital pulmonary venous stenosis presenting as persistent pulmonary hypertension of the newborn

Autor: R G, Holcomb, R W, Tyson, D D, Ivy, S H, Abman, J P, Kinsella

Publikováno v: Pediatric pulmonology. 28(4)

Congenital pulmonary venous stenosis (CPVS) has been previously described in older infants and children, typically manifesting as failure to thrive with congestive heart failure and subsequent respiratory deterioration. We report on 2 cases of CPVS w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e539a48188ca959484526ce314ca6b5
https://pubmed.ncbi.nlm.nih.gov/10497380

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Intravascular ultrasonic characteristics and vasoreactivity of the pulmonary vasculature in children with pulmonary hypertension

Autor: D D, Ivy, S R, Neish, O A, Knudson, M R, Nihill, M S, Schaffer, R W, Tyson, S H, Abman, E M, Shaffer, L, Valdes-Cruz

Publikováno v: The American journal of cardiology. 81(6)

We sought to describe the morphologic characteristics of pulmonary arteries by intravascular ultrasound (IVUS) in children with and without pulmonary hypertension to compare these anatomic findings with those of pulmonary wedge angiography, and to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bce684a04365580476ee582e064fe1f
https://pubmed.ncbi.nlm.nih.gov/9527085

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Mechanisms of abnormal vasoreactivity in persistent pulmonary hypertension of the newborn infant

Autor: S H, Abman, D D, Ivy, J W, Ziegler, J P, Kinsella

Publikováno v: Journal of perinatology : official journal of the California Perinatal Association. 16(2 Pt 2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d04d981b320e45f1602c09a6628cd37
https://pubmed.ncbi.nlm.nih.gov/8732544

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The role of nitric oxide, endothelin, and prostaglandins in the transition of the pulmonary circulation

Autor: J W, Ziegler, D D, Ivy, J P, Kinsella, S H, Abman

Publikováno v: Clinics in perinatology. 22(2)

This review emphasizes the importance of three endothelial-derived products in regulating fetal and transitional pulmonary vascular tone. Although the pathophysiologic events that culminate in PPHN are poorly understood, it is likely that endothelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2222e10cc00a9149e6359ef84e59cfc0
https://pubmed.ncbi.nlm.nih.gov/7671544

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