Výsledky vyhledávání - "D. Craig Willcox"

Akademický článek

Oxidative Stress and Longevity in Okinawa: An Investigation of Blood Lipid Peroxidation and Tocopherol in Okinawan Centenarians

Autor: Makoto Suzuki, D. Craig Willcox, Matthew W. Rosenbaum, Bradley J. Willcox

Publikováno v: Current Gerontology and Geriatrics Research, Vol 2010 (2010)

Background. The Free Radical Theory of Aging mechanistically links oxidative stress to aging. Okinawa has among the world's longest-lived populations but oxidative stress in this population has not been well characterized. Methods. We compared plasma

Externí odkaz: https://doaj.org/article/8c78a4758665497cb53558a404bea00d

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Akademický článek

Physical Aspects of Healthy Aging: Assessments of Three Measures of Balance for Studies in Middle-Aged and Older Adults

Autor: Clementina D. Ceria-Ulep, John Grove, Randi Chen, Kamal H. Masaki, Beatriz L. Rodriguez, Tim A. Donlon, Jack Guralnik, Bradley J. Willcox, D. Craig Willcox, Claudio Nigg, J. David Curb

Publikováno v: Current Gerontology and Geriatrics Research, Vol 2010 (2010)

Objectives. To investigate the reliability and correlations with age of the balance components of the EPESE, NHANES, and the Good Balance Platform System (GBPS) in a normal population of adults. Design. Cross-sectional. Setting. Urban Medical Center

Externí odkaz: https://doaj.org/article/1b1c0bba383442a38884b348bc485c88

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Forkhead box O3 longevity genotype may attenuate the impact of hypertension on risk of intracerebral haemorrhage

Autor: Kazuma, Nakagawa, Randi, Chen, Steven M, Greenberg, G Webster, Ross, Bradley J, Willcox, Timothy A, Donlon, Richard C, Allsopp, D Craig, Willcox, Brian J, Morris, Kamal H, Masaki

Publikováno v: Journal of Hypertension. 40:2230-2235

Since the G allele of forkhead box O3 ( FOXO3 ) single nucleotide polymorphism (SNP) rs2802292 is associated with resilience and longevity, ostensibly by mitigating the adverse effects of chronic cardiometabolic stress on mortality, our aim was to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841e1fe107b61bdc074b7eb3d6ca88e4
https://doi.org/10.1097/hjh.0000000000003249

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The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study

Publikováno v: The Journals of Gerontology: Series A. 77:1542-1548

The G allele of FOXO3 gene (single-nucleotide polymorphism; rs2802292) is strongly associated with human longevity. However, knowledge of the effect of FOXO3 in older populations, men or women, with heart disease is limited. This cross-sectional stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8523cee65e92a80d470d5aaaabc0d2c4
https://doi.org/10.1093/gerona/glab204

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Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension

Autor: Richard C. Allsopp, Timothy A. Donlon, Kamal Masaki, Randi Chen, Bradley J. Willcox, Brian J. Morris, D. Craig Willcox

Publikováno v: Aging (Albany NY)

The single nucleotide polymorphism (SNP) rs4130113 of the growth hormone receptor gene (GHR) is associated with longevity. Here we explored whether longevity-associated genotypes protect against mortality in all individuals, or only in individuals wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7540e7fdd62ec7566223251a6c000e6d
https://doi.org/10.18632/aging.203133

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Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease

Autor: Brian J. Morris, D. Craig Willcox, Randi Chen, Kamal Masaki, Richard C. Allsopp, Timothy A. Donlon, Bradley J. Willcox

Publikováno v: Aging. 13:7953-7974

Genetic variants of the kinase signaling gene MAP3K5 are associated with longevity. Here we explore whether the longevity-association involves protection against mortality in all individuals, or only in individuals with aging-related diseases. We tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55b40efc6d120b4c20465f52f7a8e09d
https://doi.org/10.18632/aging.202844

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FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease

Autor: Philip M C Davy, Brian J. Morris, Bradley J. Willcox, D. Craig Willcox, Timothy A. Donlon, Randi Chen, Kamal Masaki, Richard C. Allsopp

Publikováno v: Aging (Albany NY)

FOXO3 is a prominent longevity gene. To date, no-one has examined whether longevity-associated FOXO3 genetic variants protect against mortality in all individuals, or only in those with aging-related diseases. We therefore tested longevity-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655ecb968aa7a125aa359bf34c21f33d
https://doi.org/10.18632/aging.202175

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