Optimization of the synthesis of BET BD2 selective inhibitor XY153.

Autor: Zhu R; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China., Li J; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China., Dong R; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China.; School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin, 130021, China., Hu Q; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China., Chen Z; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Chen X; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhong Z; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Xiang Q; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China., Huang C; Jiangsu S&T Exchange Center with Foreign Countries, No. 175 Longpan Road, Nanjing, 210042, China., Lin B; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China., Wu X; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China., Zhang Y; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China., Zhao L; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Xu Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou, 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou, 510530, China.; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Feb; Vol. 21 (2), pp. e202301584. Date of Electronic Publication: 2024 Jan 12.

Triple Regioselective Functionalization of Cationic [4]Helicenes via Iridium‐Catalyzed Borylation and Suzuki Cross‐Coupling Reactivity.

Autor: Frédéric, Lucas¹ (AUTHOR), Fabri, Bibiana¹ (AUTHOR), Guénée, Laure² (AUTHOR), Zinna, Francesco³ (AUTHOR), Di Bari, Lorenzo³ (AUTHOR), Lacour, Jérôme¹ (AUTHOR) jerome.lacour@unige.ch

Publikováno v: Chemistry - A European Journal. 10/7/2022, Vol. 28 Issue 56, p1-9. 9p.

Protecting Group‐Controlled Regioselective Synthesis for Unsymmetrical 3,5‐Disubstituted Pyridones.

Autor: Kwon, Yong‐Ju¹ (AUTHOR), Kim, Won‐Suk¹ (AUTHOR) wonsukk@ewha.ac.kr

Publikováno v: Advanced Synthesis & Catalysis. 4/12/2022, Vol. 364 Issue 8, p1440-1449. 10p.

Regioselective N‐Functionalization of Tautomerizable Heterocycles through Methyl Trifluoromethanesulfonate‐Catalyzed Substitution of Alcohols and Alkyl Group Migrations.

Autor: Duari, Surajit¹ (AUTHOR), Biswas, Subrata¹ (AUTHOR), Roy, Arnab¹ (AUTHOR), Maity, Srabani¹ (AUTHOR), Mishra, Abhishek Kumar² (AUTHOR), de Souza, Aguinaldo R.³ (AUTHOR), Elsharif, Asma M.⁴ (AUTHOR), Morgon, Nelson H.⁵ (AUTHOR) nhmorgon@unicamp.br, Biswas, Srijit¹ (AUTHOR) sbchem@caluniv.ac.in

Publikováno v: Advanced Synthesis & Catalysis. Feb2022, Vol. 364 Issue 4, p865-872. 8p.

Synthesis of arene-functionalized fused heterocyclic scaffolds via a regioselective cascade 1,4-conjugate addition/5-exo-dig annulation strategy.

Autor: He, Xinwei, Wang, Demao, Liu, Yanan, Wu, Mengdi, Kong, Yangzilin, Tang, Qiang, Wang, Yiping, Fan, Chenli, Shang, Yongjia

Publikováno v: Organic & Biomolecular Chemistry; 12/14/2023, Vol. 21 Issue 46, p9159-9172, 14p