Zobrazeno 1 - 10
of 74
pro vyhledávání: '"D. Colevas"'
Autor:
Guolan Lu, Naoki Nishio, Nynke S. van den Berg, Brock A. Martin, Shayan Fakurnejad, Stan van Keulen, Alexander D. Colevas, Greg M. Thurber, Eben L. Rosenthal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Antibody-drug conjugates targeting high expression receptors can suffer from poor tumour penetration. Here, the authors use unconjugated antibody to improve the penetration of an antibody-dye conjugate in a clinical study, supporting further clinical
Externí odkaz:
https://doaj.org/article/1938690d6e61435ab3bfc4f49f1afa68
Autor:
Eric Wu, Alexandro E Trevino, Zhenqin Wu, Kyle Swanson, Honesty J Kim, H Blaize D’Angio, Ryan Preska, Aaron E Chiou, Gregory W Charville, Piero Dalerba, Umamaheswar Duvvuri, Alexander D Colevas, Jelena Levi, Nikita Bedi, Serena Chang, John Sunwoo, Ann Marie Egloff, Ravindra Uppaluri, Aaron T Mayer, James Zou
Publikováno v:
PNAS Nexus.
Multiplex immunofluorescence (mIF) assays multiple protein biomarkers on a single tissue section. Recently, high-plex CODEX (co-detection by indexing) systems enable simultaneous imaging of 40+ protein biomarkers, unlocking more detailed molecular ph
Autor:
Antonio Jimeno, Barbara Burtness, Jing Wang, Ruzanna Atoyan, Anna W. Ma, Ranee Mehra, David Raben, Nabil F. Saba, Julie E. Bauman, Jill Gilbert, Alexander D. Colevas, Lori J. Wirth, Thomas J. Galloway
Supplemental Figure 2. FISH analysis of EGFR and HER2 gene amplification in the archival tumor biopsies from 2 patients who received 275 mg/m2 of CUDC-101.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fed4816cda2643233a5b4173f2ef463
https://doi.org/10.1158/1078-0432.22461693
https://doi.org/10.1158/1078-0432.22461693
Autor:
Eben L. Rosenthal, Alexander D. Colevas, Mrudula Penta, Nancy Fischbein, Christina S. Kong, Rebecca W. Gao, Quan Zhou, Stefania U. Chirita, Ashley J. Zhu, Naoki Nishio, Stan van Keulen, Nynke S. van den Berg, Brock A. Martin, Shayan Fakurnejad, Guolan Lu
Purpose:The efficacy of antibody-based therapeutics depends on successful drug delivery into solid tumors; therefore, there is a clinical need to measure intratumoral antibody distribution. This study aims to develop and validate an imaging and compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41fac1b0d7a3083b2b6fd8e06d52577
https://doi.org/10.1158/1078-0432.c.6530093.v1
https://doi.org/10.1158/1078-0432.c.6530093.v1
Autor:
Eben L. Rosenthal, Jason M. Warram, Alexander D. Colevas, Christina S. Kong, F. Christopher Holsinger, Adam J. Gomez, Willemieke S.F.J. Tummers, Robert Ertsey, Guolan Lu, Steven S. Hong, Michael J. Kaplan, Vasu Divi, Nicholas J. Oberhelman, Brock A. Martin, Nynke S. van den Berg, Nutte T. Teraphongphom, Rebecca W. Gao
1. Supplementary Figure 1: Patient and tumor characteristics. 2. Supplementary Figure 2: Flow diagram of tumor-mapping analysis. The primary tumor specimen (A) is imaged using a closed-field fluorescence imaging device (B) and sectioned into breadloa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048934cada2ef737e1d119efb2ab8f59
https://doi.org/10.1158/0008-5472.22426549.v1
https://doi.org/10.1158/0008-5472.22426549.v1
Autor:
Eben L. Rosenthal, Jason M. Warram, Alexander D. Colevas, Christina S. Kong, F. Christopher Holsinger, Adam J. Gomez, Willemieke S.F.J. Tummers, Robert Ertsey, Guolan Lu, Steven S. Hong, Michael J. Kaplan, Vasu Divi, Nicholas J. Oberhelman, Brock A. Martin, Nynke S. van den Berg, Nutte T. Teraphongphom, Rebecca W. Gao
For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2227aac7983a17b0abfc48cfd82df
https://doi.org/10.1158/0008-5472.c.6512374
https://doi.org/10.1158/0008-5472.c.6512374
Autor:
Antonio Jimeno, Barbara Burtness, Jing Wang, Ruzanna Atoyan, Anna W. Ma, Ranee Mehra, David Raben, Nabil F. Saba, Julie E. Bauman, Jill Gilbert, Alexander D. Colevas, Lori J. Wirth, Thomas J. Galloway
Supplemental Figures Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17041e02a13d2c26b906073cd1916b8e
https://doi.org/10.1158/1078-0432.22461687
https://doi.org/10.1158/1078-0432.22461687
Autor:
Antonio Jimeno, Barbara Burtness, Jing Wang, Ruzanna Atoyan, Anna W. Ma, Ranee Mehra, David Raben, Nabil F. Saba, Julie E. Bauman, Jill Gilbert, Alexander D. Colevas, Lori J. Wirth, Thomas J. Galloway
Purpose: CUDC-101 is a small molecule that simultaneously inhibits the epidermal growth factor receptor (EGFR), human growth factor receptor 2 (HER2), and histone deacetylase (HDAC) with preclinical activity in head and neck squamous cell cancer (HNS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f1199bbbe73663aaeaef8570bf41a2
https://doi.org/10.1158/1078-0432.c.6524859
https://doi.org/10.1158/1078-0432.c.6524859
Autor:
Eben L. Rosenthal, Alexander D. Colevas, Mrudula Penta, Nancy Fischbein, Christina S. Kong, Rebecca W. Gao, Quan Zhou, Stefania U. Chirita, Ashley J. Zhu, Naoki Nishio, Stan van Keulen, Nynke S. van den Berg, Brock A. Martin, Shayan Fakurnejad, Guolan Lu
Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20181c28902cfbb993bf9f98efa6cff9
https://doi.org/10.1158/1078-0432.22478978.v1
https://doi.org/10.1158/1078-0432.22478978.v1
Autor:
Antonio Jimeno, Barbara Burtness, Jing Wang, Ruzanna Atoyan, Anna W. Ma, Ranee Mehra, David Raben, Nabil F. Saba, Julie E. Bauman, Jill Gilbert, Alexander D. Colevas, Lori J. Wirth, Thomas J. Galloway
Supplemental Figure 3. Ac-H3 induction in PBMCs from patients with evaluable clinical response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646cc877620040cd2f322f9be2d3d22b
https://doi.org/10.1158/1078-0432.22461690
https://doi.org/10.1158/1078-0432.22461690