Normal and inhibited cholesterol synthesis in the cultured rat embryo.

Autor: B Llirbat, C Wolf, F Chevy, D Citadelle, G Bereziat, C Roux

Publikováno v: Journal of Lipid Research, Vol 38, Iss 1, Pp 22-34 (1997)

The Smith-Lemli-Opitz syndrome-affected fetus presents a deficiency in delta7-dehydrocholesterol reductase, the last enzymatic step in the cholesterol biosynthesis pathway. Development of the abnormal human fetus takes place in a normal environment a

Externí odkaz: https://doaj.org/article/67742df3f580407086fc2073f74c9cf3

The differentiation of prehypertrophic into hypertrophic chondrocytes drives an OA-remodeling program and IL-34 expression

Autor: G. Rolland-Valognes, Xavier Houard, Francis Berenbaum, D. Valour, G. Nourissat, D. Citadelle, L. Grégoire, M.-H. Lafage-Proust, Alain Sautet, A. Pigenet, D. Cléret, Sophie Courtade-Gaiani, S. van Eegher, I. Toillon, C. Bourrier, P. Pastoureau, S. Malbos, F. De Ceuninck, M.-L. perez-Lozano

Publikováno v: Osteoarthritis and Cartilage
Osteoarthritis and Cartilage, Elsevier, 2021, 29 (2), pp.257-268. ⟨10.1016/j.joca.2020.10.013⟩
Osteoarthritis and Cartilage, 2021, 29 (2), pp.257-268. ⟨10.1016/j.joca.2020.10.013⟩

Summary Objectives We hypothesize that chondrocytes from the deepest articular cartilage layer are pivotal in maintaining cartilage integrity and that the modification of their prehypertrophic phenotype to a hypertrophic phenotype will drive cartilag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c76d265c9e97e0de548cc58357d909a
https://pubmed.ncbi.nlm.nih.gov/33301945

Knee and hip intra-articular adipose tissues share a common phenotype in osteoarthritis

Autor: Florent Eymard, J. Tordjmann, d. Citadelle, Karine Clément, Xavier Houard, Xavier Chevalier, C.-H. Flouzat Lachaniette, Francis Berenbaum, A. Pigenet

Publikováno v: Osteoarthritis and Cartilage. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfef023a34c1a0022030795648bec0a

Inhibition of 7-dehydrocholesterol reductase by the teratogen AY9944: A rat model for Smith-Lemli-Opitz syndrome

Autor: Claude Wolf, Martine Kolf-Clauw, Charles Roux, Françoise Chevy, B. Siliart, D. Citadelle

Publikováno v: Teratology. 54:115-125

Our aim is to verify the validity of a rat model proposed for Smith-Lemli-Opitz (SLO)syndrome, a developmental disorder characterized by a defect in 7-dehydrocholesterol-Δ7 (7DHC)-reductase and by facial dysmorphism close to the holoprosencephaly ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e301ef0e33cfee9080756340946a7da
https://doi.org/10.1002/(sici)1096-9926(199609)54:3<115::aid-tera1>3.0.co

Serotonin deficiency in phenylketonuria embryopathy

Autor: F. Rey, Ch. Roux, J.M. Launay, M. Madani, N. Mulliez, D. Citadelle, M. Kolf

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 9(5)

The development and evolution of PKU can be prevented by prescribing an appropriate diet at an early age. A systematic neonatal screening has been set up in most countries. However, young women suffering from PKU give birth to very severely malformed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b7c8c98bf04559e03029c95ee28f00
https://pubmed.ncbi.nlm.nih.gov/20650141