Zobrazeno 1 - 10
of 765
pro vyhledávání: '"D. Carvajal"'
Autor:
Chia-Chi Lin, Elena Garralda, Patrick Schöffski, David S. Hong, Lillian L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, Brigette Ma, Chrisann Kyi, Daniel SW Tan, Philippe A. Cassier, John Sarantopoulos, Andrew Weickhardt, Richard D. Carvajal, Jennifer Spratlin, Taito Esaki, Fréderic Rolland, Wallace Akerley, Barbara Deschler-Baier, Lawrence Rispoli, Tanay S. Samant, Niladri Roy Chowdhury, Daniel Gusenleitner, Eunice L. Kwak, Vasileios Askoxylakis, Filippo De Braud
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTIeramilimab, a humanized anti-LAG-3 monoclonal antibody, was well tolerated in combination with the anti-PD-1 antibody spartalizumab in a phase 1 study. This phase 2 study aimed to further investigate the efficacy and safety of combination tr
Externí odkaz:
https://doaj.org/article/fba32163599d40e7abcb0008f2589a1a
Autor:
Jessica C Hassel, Alexander N Shoushtari, Omid Hamid, Takami Sato, Paul Nathan, Marcus O Butler, Jason J Luke, Richard D Carvajal, Leonel Hernandez-Aya, Douglas B Johnson, Laura Collins, Enrique Espinosa, Joseph J Sacco, Serge Leyvraz, Alexandra Ikeguchi, Matthew Rioth, Chris Holland, Josep M Piulats
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background Tebentafusp, a bispecific (gp100×CD3) ImmTAC, significantly improved overall survival (OS) outcomes for HLA-A*02:01+ adult patients with untreated metastatic uveal melanoma (mUM) and showed promising survival in previously treated mUM wit
Externí odkaz:
https://doaj.org/article/b89b2a51187f4158bed6c6e774c8ce00
Autor:
D. Carvajal, D. Araya
Publikováno v:
Chemical Engineering Transactions, Vol 29 (2012)
The aim of this work is the estimation of the potential energy saving in the metropolis zone of Valparaiso (Chile), using Thermal Solar Systems (TSS) integrated to the household roof without glass protection. This selection has two effects, reduce th
Externí odkaz:
https://doaj.org/article/48da034a6ca743acaec962ce66c43cbc
Publikováno v:
Chemical Engineering Transactions, Vol 29 (2012)
The main objective of this work is to develop a suitable fluid dynamic model of a CO2 absorption system using ionic liquids as solvent giving special emphasis in the impact of the viscosity of the solvent on the reactor designing issues such as overa
Externí odkaz:
https://doaj.org/article/328a3a0bd00f43edbafc3b5725329237
Autor:
Celine M. Schreidah, BS, George Bingham Reynolds, MS, Lauren M. Fahmy, BS, Richard D. Carvajal, MD, Maarten H. Vermeer, MD, Sean Whittaker, MD, Itsik Pe’er, PhD, Larisa J. Geskin, MD
Publikováno v:
JAAD International, Vol 12, Iss , Pp 24-31 (2023)
Externí odkaz:
https://doaj.org/article/c29058b159354fdd87c91ab23cefb753
Autor:
Ernesto Rossi, Richard D. Carvajal
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/60c26823dabf4a14b746c79702a4ee42
Autor:
Paolo A. Ascierto, Sanjiv S. Agarwala, Christian Blank, Corrado Caracò, Richard D. Carvajal, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Jean-Jacques Grob, Omid Hamid, Michelle Krogsgaard, Roger S. Lo, Amanda W. Lund, Gabriele Madonna, Olivier Michielin, Bart Neyns, Iman Osman, Solange Peters, Poulikos I. Poulikakos, Sergio A. Quezada, Bradley Reinfeld, Laurence Zitvogel, Igor Puzanov, Magdalena Thurin
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Advances in immune checkpoint and combination therapy have led to improvement in overall survival for patients with advanced melanoma. Improved understanding of the tumor, tumor microenvironment and tumor immune-evasion mechanisms has result
Externí odkaz:
https://doaj.org/article/eceaa54ada8b4252a49fcbe967456d2a
Autor:
Sebastian Bauer, James Larkin, F. Stephen Hodi, Frank Stephen, Ellen H. W. Kapiteijn, Gary K. Schwartz, Emilano Calvo, Padmaja Yerramilli-Rao, Sophie Piperno-Neumann, Richard D. Carvajal
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BackgroundUveal melanoma is a disease characterized by constitutive activation of the G alpha pathway and downstream signaling of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway. While limited clinical activity has been
Externí odkaz:
https://doaj.org/article/333ba02eee294c13b68620231919623d
Autor:
Shaheer Khan, Jose Lutzky, Alexander N. Shoushtari, Joanne Jeter, Brian Marr, Thomas E. Olencki, Colleen M. Cebulla, Mohamed Abdel-Rahman, J. William Harbour, Naomi Sender, Alexandra Nesson, Shahnaz Singh-Kandah, Susana Hernandez, Jeanelle King, Manpreet S. Katari, Lyssa Dimapanat, Stephanie Izard, Grazia Ambrosini, Oliver Surriga, Alex J. Rai, Codruta Chiuzan, Gary K. Schwartz, Richard D. Carvajal
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionApproximately 40% of patients with uveal melanoma (UM) will develop metastatic disease. Tumors measuring at least 12mm in basal diameter with a class 2 signature, as defined by a widely used gene expression-profiling test, are associated
Externí odkaz:
https://doaj.org/article/6d9c9f02602b4cf392e58ac3bafdaab3
Autor:
Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Christian Blank, Richard D. Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Roger S. Lo, Georgina V. Long, Jason J. Luke, Iman Osman, Michael A. Postow, Ryan J. Sullivan, Janis M. Taube, Giorgio Trinchieri, Hassane M. Zarour, Corrado Caracò, Magdalena Thurin
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-22 (2020)
Abstract The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted monoclonal antibody, both of which significantly impr
Externí odkaz:
https://doaj.org/article/f2b099b821ea4c5eaa13a1fff3485d97