Zobrazeno 1 - 10
of 19
pro vyhledávání: '"D. C. Underwood"'
Autor:
D C, Underwood, R R, Osborn, C J, Kotzer, J L, Adams, J C, Lee, E F, Webb, D C, Carpenter, S, Bochnowicz, H C, Thomas, D W, Hay, D E, Griswold
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB 239063[trans-1-(4-hydroxycyclohexyl) -4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole], was investigated in vivo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad7ba37cf0e2b9aba0d71fd1b23c0b7
https://pubmed.ncbi.nlm.nih.gov/10734180
https://pubmed.ncbi.nlm.nih.gov/10734180
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(2)
In this study, the activity of the delta-opioid receptor subtype-selective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of selective agonists of the delta-opioid receptor (SB 22712
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a390ad6006e79d72d0a155b52d47b5f
https://pubmed.ncbi.nlm.nih.gov/10640321
https://pubmed.ncbi.nlm.nih.gov/10640321
Autor:
D C, Underwood, S, Bochnowicz, R R, Osborn, C J, Kotzer, M A, Luttmann, D W, Hay, P D, Gorycki, S B, Christensen, T J, Torphy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
We evaluated the airway activity of the novel phosphodiesterase type 4 inhibitor SB 207499 [Ariflo; c-4-cyano-4-(3-cyclopentyloxy-4-methoxyp henyl-r-1-cyclohexane carboxylic acid)], in the guinea pig. Ovalbumin (OA)-induced contractions of guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a0a6446448f630e896fdf7b5a7054cf
https://pubmed.ncbi.nlm.nih.gov/9864284
https://pubmed.ncbi.nlm.nih.gov/9864284
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
This study investigated the effects of the nonpeptide endothelin (ET) receptor antagonist, SB 217242, against ET-1-induced pulmonary pressor responses and in a model of hypoxia-induced pulmonary hypertension in the guinea pig. In guinea pig isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c82a62dc15baaad166bf457e82784ca
https://pubmed.ncbi.nlm.nih.gov/9399985
https://pubmed.ncbi.nlm.nih.gov/9399985
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
Selective inhibitors of the low-Km cAMP-specific phosphodiesterase (PDE4) inhibit inflammatory cell function and relax airway smooth muscle. Thus PDE4 inhibitors may be useful in the therapy of asthma. The present study was conducted to determine whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0aa83d38ce8aa4a581206ed57a71f96f
https://pubmed.ncbi.nlm.nih.gov/8996198
https://pubmed.ncbi.nlm.nih.gov/8996198
Autor:
M C, Chabot-Fletcher, D C, Underwood, J J, Breton, J L, Adams, A, Kagey-Sobotka, D E, Griswold, L A, Marshall, H M, Sarau, J D, Winkler, D W, Hay
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(3)
The peptidoleukotrienes and leukotriene B4, formed from arachidonic acid through the action of 5-lipoxygenase (5-LO), exert a spectrum of biological effects. It has been proposed that potent and selective 5-LO inhibitors will be effective therapy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::895d94839e8c0257dfc821c8849b5039
https://pubmed.ncbi.nlm.nih.gov/7791085
https://pubmed.ncbi.nlm.nih.gov/7791085
Autor:
D C, Underwood, C J, Kotzer, S, Bochnowicz, R R, Osborn, M A, Luttmann, D W, Hay, T J, Torphy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(1)
Selective inhibition of phosphodiesterase (PDE) isozymes has been shown to inhibit inflammatory cell function and relax airway smooth muscle and, thus, may be useful in the therapy of asthma. In guinea pigs sensitized to ovalbumin (OA), the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6438fb69177e748cc1af68c7066d58cc
https://pubmed.ncbi.nlm.nih.gov/8035322
https://pubmed.ncbi.nlm.nih.gov/8035322
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(1)
PGD2, the predominant prostanoid released from activated human lung mast cells, is metabolized to 9 alpha, 11 beta-PGF2 by an 11-ketoreductase. Both prostanoids contract mammalian airway smooth muscle. In the present study, aerosol administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e8f14ed1a5313444a71dc937feec1ff
https://pubmed.ncbi.nlm.nih.gov/8301572
https://pubmed.ncbi.nlm.nih.gov/8301572
Autor:
D C, Underwood, R R, Osborn, L B, Novak, J K, Matthews, S J, Newsholme, B J, Undem, J M, Hand, T J, Torphy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(1)
Selective inhibition of the low Km cyclic AMP-specific phosphodiesterase has been shown to inhibit inflammatory cell function and relax airway smooth muscle. These studies were conducted to characterize the bronchodilator and anti-inflammatory activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc7caa2fa596bbcfb84878e0d9cc9a52
https://pubmed.ncbi.nlm.nih.gov/8392555
https://pubmed.ncbi.nlm.nih.gov/8392555
Publikováno v:
Agents and actions. 37(3-4)
Guinea pigs were actively sensitized by parenteral injections of ovalbumin (OA), house dust extract (HD) or Ascaris suum extract (As) in a variety of multidose regimens. At least 3 weeks after the initial sensitization injection, aerosols of the appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e796465fec4389e68f8fdedc908fb5d7
https://pubmed.ncbi.nlm.nih.gov/1295368
https://pubmed.ncbi.nlm.nih.gov/1295368