Výsledky vyhledávání - "D. C. Topping"

Inhalation Two-Generation Reproductive Toxicity Study of Methyl Isobutyl Ketone in Rats

Autor: Ralph Gingell, D. C. Topping, M. D. Nemec, E. J. Rauckman, K. L. Pavkov, S. B. Harris, J. A. Pitt

Publikováno v: International Journal of Toxicology. 23:127-143

To evaluate whether methyl isobutyl ketone (MIBK) affects reproductive performance, a two-generation reproduction study was conducted. MIBK was administered to 30 Sprague-Dawley rats/sex/group via whole-body inhalation at concentrations of 0, 500, 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa9e78edba69f52ca65045f541db258
https://doi.org/10.1080/10915810490436351

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The effect of repeated methyl iso-butyl ketone vapor exposure on schedule-controlled operant behavior in rats

Autor: R M, David, L G, Bernard, M I, Banton, T R, Tyler, D C, Topping, M W, Gill, J L, O'Donoghue

Publikováno v: Neurotoxicology. 20(4)

Methyl iso-butyl ketone (MiBK), a commercial solvent, was selected by the US Environmental Protection Agency (US EPA) for testing under the Multi-Substance Rule for the Testing of Neurotoxicity (US EPA, 1993) using schedule-controlled operant behavio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::577f829dcf1ffb1b2e996ee09724e2e4
https://pubmed.ncbi.nlm.nih.gov/10499357

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Quantitative assessment of generalized epithelial changes in tracheal mucosa following exposure to 7,12-dimethylbenz(a)anthracene

Autor: D C, Topping, R A, Griesemer, P, Nettesheim

Publikováno v: Cancer research. 39(12)

Sequential morphological changes occurring after brief carcinogen exposures of heterotopic tracheal transplants in rats were semiquantitatively studied. Tracheas were exposed to 7,12-dimethylbenz(a)anthracene for 1, 2, or 4 weeks, during which time m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbdd320619dd91a1673c927975eafba9
https://pubmed.ncbi.nlm.nih.gov/115580

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Development of a system for controlled release of benzo(a)pyrene, 7,12-dimethylbenz(a)anthracene, and phorbol ester for tumor induction in heterotopic tracheal grafts

Autor: B C, Pal, D C, Topping, R A, Griesemer, F R, Nelson, P, Nettesheim

Publikováno v: Cancer research. 38(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91328d194d9b349cb848222ab062d0ec
https://pubmed.ncbi.nlm.nih.gov/416907

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Development and fate of focal epithelial lesions in tracheal mucosa following exposure to 7,12-dimethylbenz(a)anthracene

Autor: D C, Topping, R A, Griesemer, P, Nettesheim

Publikováno v: Cancer research. 39(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::424a6ddb1053133ae4c1d3fa20d88773
https://pubmed.ncbi.nlm.nih.gov/115581

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Two-stage carcinogenesis studies with asbestos in Fischer 344 rats

Autor: D C, Topping, P, Nettesheim

Publikováno v: Journal of the National Cancer Institute. 65(3)

The cocarcinogenic effect of chrysotile asbestos was investigated in heterotopic tracheal transplants of F344 rats. Tracheal transplants were first exposed to graded doses of dimethylbenz[a]anthracene (DMBA) contained in intraluminal pellets. The dos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9049174be039a850dcab6107f383dfa5
https://pubmed.ncbi.nlm.nih.gov/6774154

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Host and environmental factors enhancing carcinogenesis in the respiratory tract

Autor: R Jamasbi, P Nettesheim, D C Topping

Publikováno v: Annual review of pharmacology and toxicology. 21

Particularly in deaing with occupational lung cancer, it is often difficult to identify the major causative agent(s) or cofactor(s) in the complex work environment. The problem is further compounded by various factors that may predispose individuals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a121c669a536cf1c00954d43a511ed97
https://pubmed.ncbi.nlm.nih.gov/7016003

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Studies of neoplastic development in respiratory tract epithelium

Autor: P, Nettesheim, A J, Klein-Szanto, A C, Marchok, V E, Steele, M, Terzaghi, D C, Topping

Publikováno v: Archives of pathologylaboratory medicine. 105(1)

The dynamics of neoplastic development in conducting airways were studied in an animal model using morphologic and tissue culture techniques. Evidence for the regression of many metaplastic-dysplastic lesions, including advanced "preneoplastic" lesio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09d729542496bbb36dde04697916b536
https://pubmed.ncbi.nlm.nih.gov/6779777

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Promotion-like enhancement of tracheal carcinogenesis in rats by 12-O-tetradecanoylphorbol-13-acetate

Autor: D C, Topping, P, Nettesheim

Publikováno v: Cancer research. 40(12)

Experiments were conducted to determine whether two-stage carcinogenesis could be observed in rat tracheal epithelium using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as promoter. Heterotopic tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cef368fe7aa93984370f9201014040bf
https://pubmed.ncbi.nlm.nih.gov/6777037

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Toxic and tumorigenic effects of asbestos on tracheal mucosa

Autor: D C, Topping, P, Nettesheim, D H, Martin

Publikováno v: Journal of environmental pathology and toxicology. 3(5-6)

The purpose of the studies was to examine the acute, chronic, and neoplastic effects of asbestos on mucosa of conducting airways. Heterotopic tracheal grafts were used as the experimental model. In the system employed, the test substance was introduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53b422327e93921a881921b07d1c612b
https://pubmed.ncbi.nlm.nih.gov/7441084

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