Zobrazeno 1 - 10
of 53
pro vyhledávání: '"D. C. Topping"'
Autor:
Ralph Gingell, D. C. Topping, M. D. Nemec, E. J. Rauckman, K. L. Pavkov, S. B. Harris, J. A. Pitt
Publikováno v:
International Journal of Toxicology. 23:127-143
To evaluate whether methyl isobutyl ketone (MIBK) affects reproductive performance, a two-generation reproduction study was conducted. MIBK was administered to 30 Sprague-Dawley rats/sex/group via whole-body inhalation at concentrations of 0, 500, 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa9e78edba69f52ca65045f541db258
https://doi.org/10.1080/10915810490436351
https://doi.org/10.1080/10915810490436351
Publikováno v:
Neurotoxicology. 20(4)
Methyl iso-butyl ketone (MiBK), a commercial solvent, was selected by the US Environmental Protection Agency (US EPA) for testing under the Multi-Substance Rule for the Testing of Neurotoxicity (US EPA, 1993) using schedule-controlled operant behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::577f829dcf1ffb1b2e996ee09724e2e4
https://pubmed.ncbi.nlm.nih.gov/10499357
https://pubmed.ncbi.nlm.nih.gov/10499357
Publikováno v:
Cancer research. 39(12)
Sequential morphological changes occurring after brief carcinogen exposures of heterotopic tracheal transplants in rats were semiquantitatively studied. Tracheas were exposed to 7,12-dimethylbenz(a)anthracene for 1, 2, or 4 weeks, during which time m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbdd320619dd91a1673c927975eafba9
https://pubmed.ncbi.nlm.nih.gov/115580
https://pubmed.ncbi.nlm.nih.gov/115580
Publikováno v:
Cancer research. 38(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91328d194d9b349cb848222ab062d0ec
https://pubmed.ncbi.nlm.nih.gov/416907
https://pubmed.ncbi.nlm.nih.gov/416907
Publikováno v:
Cancer research. 39(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::424a6ddb1053133ae4c1d3fa20d88773
https://pubmed.ncbi.nlm.nih.gov/115581
https://pubmed.ncbi.nlm.nih.gov/115581
Autor:
D C, Topping, P, Nettesheim
Publikováno v:
Journal of the National Cancer Institute. 65(3)
The cocarcinogenic effect of chrysotile asbestos was investigated in heterotopic tracheal transplants of F344 rats. Tracheal transplants were first exposed to graded doses of dimethylbenz[a]anthracene (DMBA) contained in intraluminal pellets. The dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9049174be039a850dcab6107f383dfa5
https://pubmed.ncbi.nlm.nih.gov/6774154
https://pubmed.ncbi.nlm.nih.gov/6774154
Publikováno v:
Annual review of pharmacology and toxicology. 21
Particularly in deaing with occupational lung cancer, it is often difficult to identify the major causative agent(s) or cofactor(s) in the complex work environment. The problem is further compounded by various factors that may predispose individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a121c669a536cf1c00954d43a511ed97
https://pubmed.ncbi.nlm.nih.gov/7016003
https://pubmed.ncbi.nlm.nih.gov/7016003
Publikováno v:
Archives of pathologylaboratory medicine. 105(1)
The dynamics of neoplastic development in conducting airways were studied in an animal model using morphologic and tissue culture techniques. Evidence for the regression of many metaplastic-dysplastic lesions, including advanced "preneoplastic" lesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09d729542496bbb36dde04697916b536
https://pubmed.ncbi.nlm.nih.gov/6779777
https://pubmed.ncbi.nlm.nih.gov/6779777
Autor:
D C, Topping, P, Nettesheim
Publikováno v:
Cancer research. 40(12)
Experiments were conducted to determine whether two-stage carcinogenesis could be observed in rat tracheal epithelium using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as promoter. Heterotopic tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cef368fe7aa93984370f9201014040bf
https://pubmed.ncbi.nlm.nih.gov/6777037
https://pubmed.ncbi.nlm.nih.gov/6777037
Publikováno v:
Journal of environmental pathology and toxicology. 3(5-6)
The purpose of the studies was to examine the acute, chronic, and neoplastic effects of asbestos on mucosa of conducting airways. Heterotopic tracheal grafts were used as the experimental model. In the system employed, the test substance was introduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53b422327e93921a881921b07d1c612b
https://pubmed.ncbi.nlm.nih.gov/7441084
https://pubmed.ncbi.nlm.nih.gov/7441084